CAS: 124-58-3; Methylarsonic Acid

该化合物是一种有机分析化合物,其结构特征包括附于砷原子的一组甲基化合物,以及一个箱状酸功能组,该化合物通常作为白色晶状固体遇到,在水中可溶解,便于其在环境环境中的流动性;甲基氮酸主要用作除草剂,并研究其含砷含量对人类健康和环境的潜在影响;已知该化合物具有毒理学和生物化学特性,引起人们对其给生态系统和人类暴露的影响的关切;该化合物在生物系统中可发生各种变化,导致形成其他砷物种;其环境行为受到诸如pH,温度和其他化学品的存在等因素的影响,使其成为环境化学和毒理学方面持续研究的对象.

结构式图片

MSDS等安全信息

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

CAS号74-88-4 碘甲烷 | CAS号74-87-3 氯甲烷 | CAS号75-60-5 卡可基酸 | CAS号512-42-5 硫酸甲酯钠 | CAS号80-48-8 对甲苯磺酸甲酯 | CAS号593-58-8 甲基氧化胂 | CAS号593-52-2 methylarsine | CAS号593-89-5 Methyldichloroa... | CAS号110-93-0 甲基庚烯酮 | CAS号69065-31-2 (E)-°Ct-4-en-3-one | CAS号7207-97-8 Methylarsonous ... | CAS号75-60-5 卡可基酸 | CAS号124-38-9 二氧化碳 | CAS号7778-39-4 砷酸、原砷酸 | CAS号676-70-0 dibromo(methyl)... | CAS号593-89-5 Methyldichloroa... | CAS号38729-07-6 diiodo-methyl-amine

合成工艺路线路线简述

    📜氯甲烷置于trisodium Arsenite,水体系中,60.0 °C,392.24 Kpa 条件下,反应生成甲基胂酸
    参考文献:Process Of Methylating Sodium Ortho Arsenite
    标题:Process Of Methylating Sodium Ortho Arsenite

    专利信息


    专利号:US-11667658-B2
    优先权日:2021-06-30
    标 题:Chemical synthesis of the organoarsenical antibiotic arsinothricin
    发明人:ROSEN BARRY P; YOSHINAGA MASAFUMI; WNUK STANISLAW F; HOWLADER MD ABU HASAN; SUZOL SK MD SAZZAD HOSSAIN
    权利人:ROSEN BARRY P; YOSHINAGA MASAFUMI; WNUK STANISLAW F; HOWLADER MD ABU HASAN; SUZOL SK MD SAZZAD HOSSAIN; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
    摘要:The subject invention provides methods for the chemical synthesis of racemic arsinothricin (D,L-AST), the novel organoarsenical antibiotic. One is by condensation of the 2-chloroethyl(methyl)arsinic acid with acetamidomalonate, and the second involves reduction of the N-acetyl-protected derivative of hydroxyarsinothricin (AST-OH) and subsequent methylation of the resulting sodium salt of trivalent arsenic intermediate with methyl iodide. The enzyme AST N-acetyltransferase (ArsN1) was utilized to purify L-AST from racemic AST. This expedient chemical synthesis of AST provides a source of this novel antibiotic for future drug development.

    专利号:US-2025043248-A1
    优先权日:2023-08-04
    标题:Preparation method and use of hydrogel material for growth of blood vessel organoids
    发明人:SUN DI; SUN JIAMING; WANG ZHENXING; LEI SHIZE
    权利人:UNION HOSPITAL TONGJI MEDICAL COLLEGE HUST
    摘要:The present disclosure provides a preparation method and use of a hydrogel material for growth of blood vessel organoids (BVOs). The preparation method of the hydrogel material includes: (1) synthesis of gelatin methacryloyl (GelMA), and (2) synthesis of ns-GelMA-PEO. The hydrogel material may be used for in vitro cultivation of BVOs. The hydrogel material ns-GelMA-PEO prepared by the present disclosure may significantly improve the survival and budding abilities of BVOs. The ns-GelMA-PEO provides a novel solution for in vitro cultivation of BVOs, and may well support the growth and differentiation of organoids.

    专利号:US-2024158826-A1
    优先权日:2022-11-16
    标 题 :Preparation method of synthetase for continuous monitoring of blood glucose
    发明人:ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU
    权利人:ZHANG SHAODA; QIU ZHIPENG; ZHENG XINGYU
    摘要:The present invention discloses a preparation method of a synthetase for continuous monitoring of blood glucose. The method includes the preparation steps of step S1: hydroxylation of a glass bead; step S2: silanization of the glass bead; step S3: bonding of the glass bead to glucose; step S4: synthesis of a polymer particle on the surface of the glass bead to form a glucose synthetase; and step S5: separation of the highly specific glucose synthetase. According to the preparation method of a synthetase for continuous monitoring of blood glucose provided by the present invention, the glass bead is bonded to the glucose by activating the surface of the glass bead, and then bonded to a polymer to form the glucose synthetase. The artificial synthetase prepared by the method has low sensitivity to temperature and pH value, and can be directly used in a blood glucose electrochemical sensor.

    专利号:WO-2025125623-A1
    优先权日:2023-12-13
    标题 :Synthesis of surfactant-free poly(vinylidene fluoride) latexes via raft emulsion polymerization
    发明人:EID NADIM; DEVISME SAMUEL; BONNET ANTHONY; FEVRIER THIBAUT; LANSALOT MURIEL; D'AGOSTO FRANCK
    权利人:ARKEMA FRANCE; UNIV CLAUDE BERNARD LYON 1 UCBL; ECOLE SUPERIEURE DE CHIMIE PHYSIQUE ELECTRONIQUE LYON; CENTRE NAT RECH SCIENT
    摘要:The present invention relates to a process for producing a stable PVDF latex by emulsion polymerization in the absence of fluorinated surfactant, stabilized by a hydrophilic macromolecular reversible addition-fragmentation chain transfer (RAFT) agent.

    专利号:US-4473708-A
    优先权日:1981-07-09
    标题:Preparation of ketozines using organoarsenic compounds
    发明人:KURIYAMA YASUHISA; KAKUDA MINORU; NITOH SHOICHI
    权利人:MITSUBISHI GAS CHEMICAL CO
    摘要:A process for preparing a ketazine useful as an intermediate for the synthesis of hydrazine is disclosed. The process comprises reacting an aliphatic or aromatic ketone with ammonia and hydrogen peroxide in the presence of a catalyst of an arsenic compound to produce a corresponding ketazine.

    专利号:US-2024309128-A1
    优先权日:2023-03-13
    标 题 :Perfluoropyridine based polymers obtained via radical initiated methods
    发明人:JENNINGS ABBY R; IACONO SCOTT T; AULECIEMS ZACHARY J; LOCHMAIER EMELINE C
    权利人:US GOV AIR FORCE
    摘要:The synthesis of the fluorinated monomer, 2-((perfluoropyridin-4-yl)amino)ethyl methacrylate, and the use of the same in the preparation of fluorinated homo- and copolymers is provided. Such monomer was designed to contain a terminal methacrylate group, allowing for polymerization through free-radical techniques, both chain-growth and reversible addition-fragmentation chain-transfer methods. The monomer was designed to be compatible with other commercially available monomers and solvents to facilitate ease of copolymerization through free-radical polymerization techniques. The polymerization does not require perfluorinated alkyl substances or perfluorooctanoic acids or related compounds in the synthesis of the fluoropolymers.

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    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Yoshinaga M, Cai Y, Rosen BP. Demethylation of methylarsonic acid by a microbial community. Environ Microbiol. 2011 May;13(5):1205-15. doi: 10.1111/j.1462-2920.2010.02420.x. Epub 2011 Jan 27.
    2: Guindo Nignan M, Garnier R, Auger J, Ditcharles D, Dossier E, Klein E, Nguyen-Aubier D, Renault B. [Urinary excretion of mineral arsenic, methylarsonic acid and dimethylarsinic acid in workers exposed to gallium arsenide]. J Toxicol Clin Exp. 1992 Oct-Nov;12(4-5):329-31. French. Japanese. doi: 10.1124/mol.113.091314. Epub 2014 May 28. doi: 10.1539/joh.15-0241-OA. Epub 2016 Mar 24.
    9: Tokar EJ, Kojima C, Waalkes MP. Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenic. Arch Toxicol. 2014 Feb;88(2):249-61. doi: 10.1007/s00204-013-1141-2. Epub 2013 Oct 5.

    合成参考文献


    摘要:Fundamental and Applied Toxicology., 7(299), 1986
    摘要:USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
    摘要:BRAMAN RS; ARSENIC IN THE ENVIRONMENT; ACS SYMP SER; 7 (ARSENICAL PESTIC, SYMP, 1974): 108-23 (1975)
    摘要:Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 766
    摘要:USEPA; Quality Criteria for Water 1986: Arsenic: Human Health Criteria (May 1, 1986) EPA 440/5-86-001
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