CAS: 105-34-0; Methyl 2-Cyanoacetate

相似化合物

109-78-4 16695-14-0 51513-29-2

上下游产品

CAS号110-67-8 3-甲氧基丙腈 | CAS号67-56-1 甲醇 | CAS号372-09-8 氰基乙酸 | CAS号3154-54-9 甲酰氨基乙酸甲酯 | CAS号105-56-6 氰乙酸乙酯 | CAS号74-87-3 氯甲烷 | CAS号107-91-5 氰乙酰胺 | CAS号35234-87-8 dimethyl 2,3-di... | CAS号109-77-3 丙二腈 | CAS号143-33-9 氰化钠 | CAS号10255-99-9 N,N''-DIBENZYL-... | CAS号1049767-69-2 2-氨基-4,5,6,7-四氢... | CAS号100-02-7 对硝基苯酚 | CAS号105688-23-1 methyl 4-acetam... | CAS号111233-69-3 2-cyano-N-[3-[(... | CAS号111735-80-9 methyl 2-cyanoo... | CAS号105219-75-8 (5,6-二甲基-4-氧代-3... | CAS号31295-20-2 N-乙酰基-β-丙氨酸甲酯 | CAS号351156-65-5 2-AMINO-4-NAPHT... | CAS号497-25-6 2-恶唑烷酮

甲基丙二酰胺置于lead Acetate体系中,用 二氯甲烷 用作溶剂,化学反应 12.0H,以86%的收率获得氰乙酸甲酯
参考文献:铅盐催化的伯酰胺容易脱水成腈:阴离子配体很重要
标题:铅盐催化的伯酰胺容易脱水成腈:阴离子配体很重要
摘要:在温和条件下腈的合成是通过使用铅盐作为催化剂使伯酰胺脱水来实现的.通过不仅添加表面活性剂,而且连续地从体系中除去唯一的副产物水来增强反应过程.脂肪族和芳香族腈都可以这种方式制备,具有中等至极好的收率.通过高级量子化学计算获得了反应机理,并揭示了阴离子配体在转化中的关键作用.
Doi:10.1016/j.Mcat.2020.111313

专利信息

专利号:US-8269001-B2
优先权日:2005-10-05
标题 :Process for the synthesis of HMG-CoA reductase inhibitors
发明人：CASAR ZDENKO
权利人:CASAR ZDENKO; LEK PHARMACEUTICALS
摘要:A novel synthesis of statins uses Wittig reaction of a heterocyclic core of statin with a lactonized side chain already possessing needed stereochemistry. Any separation of diastereoisomers is performed early in the course of synthesis.

专利号:US-7858828-B2
优先权日:2008-03-26
标 题 :Process for synthesis of (3R,3'R,6'R)-lutein and its stereoisomers
发明人：KHACHIK FREDERICK; CHANG AN-NI
权利人:UNIV MARYLAND
摘要:(3R,3′R,6′R)-Lutein and (3R,3′R)-zeaxanthin are two dietary carotenoids that are present in most fruits and vegetables commonly consumed in the US. These carotenoids accumulate in the human plasma, major organs, and ocular tissues. In the past decade, numerous epidemiological and experimental studies have shown that lutein and zeaxanthin play an important role in the prevention of age-related macular degeneration (AMD) that is the leading cause of blindness in the U.S. and Western World. The invention provides a process for the synthesis of (3R,3′R,6′R)-lutein and its stereoisomers from commercially available (rac)-α-ionone by a C 15 +C 10 +C 15 coupling strategy. In addition, the present invention also provides access to the precursors of optically active carotenoids with 3-hydroxy-ε-end group that are otherwise difficult to synthesize. The process developed for the synthesis of lutein and its stereoisomers is straightforward and has potential for commercialization.

专利号:US-2007049757-A1
优先权日:2005-08-26
标题:Methods for the synthesis of substituted amino uracils
发明人：RIEGER JAYSON M; THOMPSON ROBERT
权利人:RIEGER JAYSON M; THOMPSON ROBERT
摘要:The invention provides novel methods of preparing substituted amino uracil compounds that can be employed as useful intermediates in the synthesis of various xanthines. Highly regioselective unsymmetrical amino uracils can be obtained using these methods which is a particular advantage over other existing methods.

专利号:US-4284582-A
优先权日:1978-04-28
标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
发明人：KAYE ALBERT E; TUCKER ALAN C
权利人:ICI LTD
摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

专利号:US-4866175-A
优先权日:1966-11-08
标 题 :Novel process for the synthesis of quinoxaline and benzimidazole-N-oxides
发明人：ISSIDORIDES COSTAS H; HADDADIN MAKHLUF J
权利人:RESEARCH CORP
摘要:The synthesis of quinoxaline and benzimidazole-N-oxides and of ester amd amide derivatives of 3-hydroxy-2-quinoxalinecarboxylic acid by a movel process consisting of the reaction between a benzofuroxan and an activated methylene-containing compound under basic conditions.

专利号:WO-2012059797-A1
优先权日:2010-11-04
标题 :Process for synthesis of (s) - pregabalin
发明人：ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
权利人:LUPIN LTD; ROY BHAIRAB NATH; SINGH GIRIJ PAL; LATHI PIYUSH SURESH; AGRAWAL MANOJ KUNJABIHARI; MITRA RANGAN; RUPNAWAR MANOJ DATTATRAYA
摘要:Improved process for the synthesis of (S)-pregabalin having more than 99% ee through (S) 3-cyano-5-methyl-hexanoic acid has been developed. In addition to above, a novel process for resolution of ( RS ) - 3-cyano-5-methyl-hexanoic acid through diastereomeric salt formation with cinchonidine to obtain ( S ) - 3-cyano-5-methyl-hexanoic acid in high yield and high optical purity has been developed and furthermore process for recovery/ reuse of cinchonidine is also developed to improve the overall process efficiency.