CAS: 85-61-0; (((2R,3S,4R,5R)-5-(6-Amino-9H-Purin-9-yl)-4-Hydroxy-2-(((Hydroxy((Hydroxy((R)-3-Hydroxy-2,2-Dimethyl-3-((2-((2-Sulfanylethyl)Carbamoyl)Ethyl)Carbamoyl)Propoxy)Phosphoryl)Oxy)Phosphoryl)Oxy)Methyl)Oxolan-3-yl)Oxy)Phosphonic Acid

上下游产品

CAS号52-90-4 L-半胱氨酸 | CAS号79-83-4 泛酸 | CAS号56-65-5 5'-三磷酸腺苷 | CAS号70-18-8 谷胱甘肽/5-L-谷氨酰-L-... | CAS号31664-36-5 辅酶 A,氧化锂盐 | CAS号6477-52-7 CoA-glutathione | CAS号1264-52-4 辛酰基辅酶A | CAS号1763-10-6 棕榈酰辅酶A,钾盐 | CAS号56-40-6 甘氨酸 | CAS号51146-56-6 (S)-(+)-布洛芬 | CAS号1926-57-4 Lactyl-CoA | CAS号2140-48-9 butyryl-CoA | CAS号61-19-8 腺苷酸 | CAS号70-18-8 谷胱甘肽/5-L-谷氨酰-L-... | CAS号6477-52-7 CoA-glutathione | CAS号31664-36-5 辅酶 A,氧化锂盐 | CAS号79-83-4 泛酸

D-泛酸 反应生成 辅酶 A
参考文献:Novelli; Lipmann,Archives Of Biochemistry,1947,Vol. 14,P. 24
标题:Novelli; Lipmann,Archives Of Biochemistry,1947,Vol. 14,P. 24

专利信息

专利号:US-12188072-B2
优先权日:2018-03-19
标题 :Compositions and methods for rapid in vitro synthesis of bioconjugate vaccines in vitro via production and N-glycosylation of protein carriers in detoxified prokaryotic cell lysates
发明人：JEWETT MICHAEL CHRISTOPHER; STARK JESSICA CAROL; DELISA MATTHEW P; JAROENTOMEECHAI THAPAKORN
权利人:UNIV NORTHWESTERN; UNIV CORNELL
摘要:Disclosed are methods, systems, components, and compositions for cell-free synthesis of glycosylated carrier proteins. The glycosylated carrier proteins may be utilized in vaccines, including anti-bacterial vaccines. The glycosylated carrier proteins may include a bacterial polysaccharide conjugated to a carrier, which may be utilized to generate an immune response in an immunized host against the polysaccharide conjugated to the carrier. The glycosylated carrier proteins may be synthesized in cell-free glycoprotein synthesis (CFGpS) systems using prokaryote cell lysates that are enriched in components for glycoprotein synthesis such as oligosaccharyltransferases (OSTs) and lipid-linked oligosaccharides (LLOs) including OSTs and LLOs associated with synthesis of bacterial O antigens.

专利号:US-6451543-B1
优先权日:1998-08-31
标题:Lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides
发明人：KOCHENDOERFER GERD G; HUNTER CHRISTIE L; KENT STEPHEN B H; BOTTI PAOLO
权利人:GRYPHON SCIENCES
摘要:The present invention relates to methods and compositions for lipid matrix-assisted chemical ligation and synthesis of membrane polypeptides that are incorporated in a lipid matrix. The invention is exemplified in production of a prefolded membrane polypeptide embedded within a lipid matrix via stepwise chemoselective chemical ligation of unprotected peptide segments, where at least one peptide segment is embedded in a lipid matrix. Any chemoselective reaction chemistry amenable for ligation of unprotected peptide segments can be employed. Suitable lipid matrices include liposomes, micelles, cell membrane patches and optically isotropic cubic lipidic phase matrices. Prefolded synthetic and semi-synthetic membrane polypeptides synthesized according to the methods and compositions of the invention also permit site-specific incorporation of one or more detectable moieties, such as a chromophore, which can be conveniently introduced during synthesis. The methods and compositions of the invention have multiple uses. For example, they can be used to assay ligand binding to membrane polypeptides and domains comprising a receptor, and thus are extremely useful for structure/function studies, drug screening/selection/design, and diagnostics and the like, including high-throughput applications. The methods and compositions of the invention are particularly suited for FRET analyses of previously inaccessible membrane polypeptides.

专利号:US-5519128-A
优先权日:1993-03-31
标题:Process for the synthesis of acylated derivatives of fatty acid-transporting thiols and in particular acyl-coenzymes A and the thus obtained acyl-coenzymes A
发明人：LELLOUCHE JEAN-PAUL; LEVANNIER KARINE; MIOSKOWSKI CHARLES
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The invention relates to a process for the synthesis of an acylated derivative of a fatty acid-transporting thiol such as the coenzyme A. According to this process, a silylated or stannylated thiol is prepared by reacting the thiol with a silylation or stannylation reagent in order to at least partly replace the unstable hydrogens of the thiol by SiR3 or SnR3 groups with R being an alkyl or aryl group. The silylated or stannylated thiol is then reacted in an anhydrous organic medium with an activated organic acid and a deprotection reagent able to eliminate the silyl or stannyl groups. In this way it is possible to obtain acylated derivatives of the coenzyme A, in which the acyl group can have up to 30 carbon atoms with high yields.

专利号:US-8492115-B2
优先权日:2005-10-31
标 题:Cell-free synthesis of membrane bound polypeptides
发明人：SWARTZ JAMES ROBERT; WUU JESSICA
权利人:SWARTZ JAMES ROBERT; WUU JESSICA; UNIV LELAND STANFORD JUNIOR
摘要:Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of membrane-associated polypeptides.

专利号:US-7871794-B2
优先权日:2007-01-18
标 题:Enhanced cell-free synthesis of active proteins containing disulfide bonds
发明人：KNAPP KURTIS G; SWARTZ JAMES ROBERT
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Compositions and methods are provided for the enhanced in vitro synthesis of active polypeptides containing disulfide bonds. In certain embodiments of the invention, the reaction mix includes a biological extract derived from a bacterial cell in which the glutathione reductase gene has been inactivated, which is pre-treated with a low concentration of a sulfhydryl inactivating agent.

专利号:US-6337197-B2
优先权日:1998-10-27
标题:Coenzymes useful for the synthesis of L-carnitine
发明人：ELSSNER THOMAS; KLEBER HANS-PETER
权利人:SIGMA TAU IND FARMACEUTI
摘要:The invention described herein relates to coenzymes useful for the synthesis of L-carnitine, particularly a compound of coenzyme A, and more particularly gamma-butyrobetainyl-coenzyme A and crotonobetainyl-coenzyme A, to procedures for their preparation and to their use for the production of L(-)-carnitine from crotonobetain and D(-)-carnitine.