CAS: 84000-11-3; Fmoc-N-Me-Val-Oh

• 英文名称Fmoc-N-Me-Val-Oh
• 中文名称Fmoc-N-甲基-L-缬氨酸
• IUPAC名称N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-methyl-L-valine
• 其它别名Fmocn甲基l缬氨酸
• CAS编号84000-11-3
• MFCD编号:MFCD00153395
• EINECS号:807-805-3
• 分子式:C21H23NO4
• 分子量:353.42
• 产品CID: 1828358
• 产品分类有机原料→生命科学→氨基酸及其衍生物→缬氨酸及其衍生物

• 相似结构搜索
• InChIKey: YCXXXPZNQXXRIG-IBGZPJMESA-N
• InChI=1S/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/…
• 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数5.0

相似化合物

物理性质

• 熔点187-190°C
• 沸点527.6±29.0 °C at 760 mmHg
• 闪点272.9±24.3 °C
• 密度1.2±0.1 g/cm3
• PH:-68 º (c=1% in DMF)
• pKa:3.92±0.10(预测)
• PSA:66.84
• LogP:3.9765
• 旋光度-68º(C=1INDMF)
• 折射率1.588
• 蒸汽压0.0±1.5 mmHg at 25°C
• 溶解性Soluble In Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,Etc.
• 外观形态白色粉末
• 储存条件2-8°C
• 产品应用该化合物用于酶基质和试剂,培养媒介添加剂,染料,污点和指标,并参与N-甲酸酯的编制.

MSDS等安全信息

• GHS符号GHS07
• 危险类别特定目标器官毒性 - 单次接触 类别3
  皮肤腐蚀/刺激 类别2
  严重眼刺激 类别2A
• 警示词Warning
• 危险描述H335 |可能引起呼吸道刺激.
  H315 |造成皮肤刺激.
  H319 |造成严重眼刺激.
• 防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
• 危险等级IRRITANT
• UN编号NONH for all modes of transport
• 危险品标志Xi
• 安全声明22-24/25
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 84000-01-1 = 84000-11-3
  反应条件:1.1 Reagents: Triethylsilane Catalysts: Aluminum Chloride Solvents: Dichloromethane; Rt
  标题:An Improved Synthesis Of Fmoc-N-Methyl-α-Amino Acids
  作者:Zhang,Suode; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2005 卷标:70(17) 页码:6918-6920]
  
  270073-00-2 + 28920-43-6 = 84000-11-3
  反应条件:1.1 Reagents: Diisopropylethylamine Solvents: Dimethylformamide,Dichloromethane; 2 H,Rt1.2 Reagents: Methanol,Diisopropylethylamine Solvents: Dichloromethane; 10 Min,Rt1.3 Solvents: Dichloromethane; 4 H,Rt1.4 Reagents: Thiophenol,Potassium Carbonate Solvents: Dimethylformamide; 10 Min,Rt1.5 Solvents: Dimethylformamide; 2 H,Rt1.6 Reagents: Diisopropylethylamine Solvents: Dichloromethane; 2 H,Rt1.7 Reagents: Acetic Acid,2,2,2-Trifluoroethanol Solvents: Dichloromethane; 2 H,Rt
  标题:Solid-Phase Synthesis Of N-Nosyl- And N-Fmoc-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2007 卷标:72(10) 页码:3723-3728]
  
  84000-11-3 = 84000-11-3
  反应条件:1.1 Reagents: Acetyl Chloride Solvents: Dichloromethane; 4 H,Rt1.2 Reagents: Diisopropylethylamine Solvents: Dichloromethane; 12 H,Rt
  标题:Conformation-Based Design And Synthesis Of Apratoxin A Mimetics Modified At The α,β-Unsaturated Thiazoline Moiety
  作者:Onda,Yuichi; Et Al
  参考文献:Journal Of Medicinal Chemistry 日期:2017 卷标:60(15) 页码:6751-6765]
  
  = 84000-11-3
  反应条件:1.1 Solvents: Dichloromethane; 1 H,Rt2.1 Reagents: Sodium Thiophenolate Solvents: Dimethylformamide; 3 H,Rt2.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 22.3 Reagents: Sodium Carbonate Solvents: Water; Ph 9; Rt -> 0 °C2.4 Solvents: 1,4-Dioxane; 3 H,0 °C2.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:An Efficient Preparation Of N-Methyl-α-Amino Acids From N-Nosyl-α-Amino Acid Phenacyl Esters
  作者:Leggio,Antonella; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(5) 页码:1386-1392]
  
  68858-20-8 = 84000-11-3
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; Reflux2.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Chloroform; 24 - 72 H,Rt
  标题:A Total Synthesis Of A Highly N-Methylated Cyclodepsipeptide [2S,3S-Hmp]-Aureobasidin L Using Solid-Phase Methods
  作者:Maharani,Rani; Et Al
  参考文献:Tetrahedron 日期:2014 卷标:70(14) 页码:2351-2358]
  
  68858-20-8 = 84000-11-3
  反应条件:1.1 Catalysts: P-Toluenesulfonic Acid Solvents: Toluene; 2 H,Reflux2.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Acetonitrile; 2 H,75 °C
  标题:Fluorenylmethoxycarbonyl-N-Methylamino Acids Synthesized In A Flow Tube-In-Tube Reactor With A Liquid-Liquid Semipermeable Membrane
  作者:Buba,Annette E.; Et Al
  参考文献:European Journal Of Organic Chemistry 日期:2013 卷标:2013(21) 页码:4509-4513]
  
  68858-20-8 = 84000-11-3
  反应条件:1.1 Reagents: P-Toluenesulfonic Acid Solvents: Toluene2.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Chloroform
  标题:Structure Elucidation And Synthesis Of Natural Products
  作者:Murphy,Annabel Christine
  参考文献:2008]
  
  270073-00-2 + 883-40-9 = 84000-11-3
  反应条件:1.1 Solvents: Dichloromethane; 40 Min,Rt2.1 Solvents: Dichloromethane; Rt; 1.5 H,Rt3.1 Reagents: Thioglycolic Acid,Sodium Methoxide Solvents: Methanol,Acetonitrile; 40 Min,50 °C4.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; 1 H,Ph 8,Rt5.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143]
  
  84000-01-1 = 84000-11-3
  反应条件:1.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Chloroform
  标题:Ionic And Organometallic-Catalyzed Organosilane Reductions
  作者:Larson,Gerald L.; Et Al
  参考文献:Organic Reactions (Hoboken 日期:2008 卷标:71 页码:1-737]
  
  84000-01-1 = 84000-11-3
  反应条件:1.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Acetonitrile; 2 H,75 °C
  标题:Fluorenylmethoxycarbonyl-N-Methylamino Acids Synthesized In A Flow Tube-In-Tube Reactor With A Liquid-Liquid Semipermeable Membrane
  作者:Buba,Annette E.; Et Al
  参考文献:European Journal Of Organic Chemistry 日期:2013 卷标:2013(21) 页码:4509-4513]
  
  1220527-59-2 = 84000-11-3
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143]
  
  2480-23-1 + 28920-43-6 = 84000-11-3
  反应条件:1.1 Reagents: Chlorotrimethylsilane Solvents: Dichloromethane; 3 H,Reflux; Reflux -> 0 °C1.2 Reagents: Diisopropylethylamine; 0 °C
  标题:Design,Conformational Studies And Analysis Of Structure-Function Relationships Of Pth (1-11) Analogues: The Essential Role Of Val In Position 2
  作者:Caporale,A.; Et Al
  参考文献:Amino Acids 日期:2012 卷标:43(1) 页码:207-218]
  
  28920-43-6 + 1208119-51-0 = 84000-11-3
  反应条件:1.1 Reagents: Sodium Thiophenolate Solvents: Dimethylformamide; 3 H,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 21.3 Reagents: Sodium Carbonate Solvents: Water; Ph 9; Rt -> 0 °C1.4 Solvents: 1,4-Dioxane; 3 H,0 °C1.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:An Efficient Preparation Of N-Methyl-α-Amino Acids From N-Nosyl-α-Amino Acid Phenacyl Esters
  作者:Leggio,Antonella; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(5) 页码:1386-1392]
  
  84000-11-3 = 84000-11-3
  反应条件:1.1 Reagents: Diisopropylethylamine,2-Chlorotrityl Chloride Resin Solvents: Dichloromethane; 3 H,Rt1.2 Reagents: Methanol; 0.5 H,Rt
  标题:Comparative Pharmacokinetic Profile Of Cyclosporine (Csa) With A Decapeptide And A Linear Analogue
  作者:Price,David A.; Et Al
  参考文献:Organic & Biomolecular Chemistry 日期:2017 卷标:15(12) 页码:2501-2506]
  
  28920-43-6 + 1220527-47-8 = 84000-11-3
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; 1 H,Ph 8,Rt2.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143]
  
  = 84000-11-3
  反应条件:1.1 Reagents: Thioglycolic Acid,Sodium Methoxide Solvents: Methanol,Acetonitrile; 40 Min,50 °C2.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; 1 H,Ph 8,Rt3.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143]
  
  270073-00-2 + 70-11-1 = 84000-11-3
  反应条件:1.1 Reagents: Cesium Carbonate Solvents: Ethanol; 0 °C; 1 H,Rt1.2 Solvents: Dimethylformamide; 1 H,Rt2.1 Solvents: Dichloromethane; 1 H,Rt3.1 Reagents: Sodium Thiophenolate Solvents: Dimethylformamide; 3 H,Rt3.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 23.3 Reagents: Sodium Carbonate Solvents: Water; Ph 9; Rt -> 0 °C3.4 Solvents: 1,4-Dioxane; 3 H,0 °C3.5 Reagents: Hydrochloric Acid Solvents: Water; Ph 2
  标题:An Efficient Preparation Of N-Methyl-α-Amino Acids From N-Nosyl-α-Amino Acid Phenacyl Esters
  作者:Leggio,Antonella; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2010 卷标:75(5) 页码:1386-1392]
  
  72-18-4 + 28920-43-6 = 84000-11-3
  反应条件:1.1 Reagents: Sodium Bicarbonate Solvents: 1,4-Dioxane,Water2.1 Reagents: P-Toluenesulfonic Acid Solvents: Toluene3.1 Reagents: Trifluoroacetic Acid,Triethylsilane Solvents: Chloroform
  标题:Structure Elucidation And Synthesis Of Natural Products
  作者:Murphy,Annabel Christine
  参考文献:2008]
  
  = 84000-11-3
  反应条件:1.1 Solvents: Dichloromethane; Rt; 1.5 H,Rt2.1 Reagents: Thioglycolic Acid,Sodium Methoxide Solvents: Methanol,Acetonitrile; 40 Min,50 °C3.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; 1 H,Ph 8,Rt4.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143]
  
  5350-57-2 = 84000-11-3
  反应条件:1.1 Reagents: Chromium Oxide Solvents: Dichloromethane; < 15 Min,Rt2.1 Solvents: Dichloromethane; 40 Min,Rt3.1 Solvents: Dichloromethane; Rt; 1.5 H,Rt4.1 Reagents: Thioglycolic Acid,Sodium Methoxide Solvents: Methanol,Acetonitrile; 40 Min,50 °C5.1 Reagents: Sodium Bicarbonate Solvents: Dichloromethane,Water; 1 H,Ph 8,Rt6.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane,Toluene; 1 H,Rt
  标题:A Preparation Of N-Fmoc-N-Methyl-α-Amino Acids And N-Nosyl-N-Methyl-α-Amino Acids
  作者:Di Gioia,Maria Luisa; Et Al
  参考文献:Amino Acids 日期:2010 卷标:38(1) 页码:133-143

海关参考信息

• 2902600000-乙苯
  2905121000-正丙醇
  2905130000-正丁醇
  2912110000-甲醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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