专利号:EP-1220834-B1 优先权日:1999-10-15 标 题:Method for the production of cyanoacetic acid esters 发明人:CHEN PETER; MUELLER ANDRE; GILBERT THOMAS 权利人:LONZA AG 摘要:The invention relates to a method wherein cyanoacetic acid -C1-4-alkyl esters are pyrolyzed to form 3,3'-bisisoxazol of formula (I) in the gas phase at reduced pressure in the presence of a C1-4-alkanol or by reaction of the pyrolysate with a C1-4-alkanol. Said cyanoacetic acid-C1-4-alkyl esters are used as intermediates in the synthesis of cyanoacrylates or pharmaceutically active agents.
专利号:WO-2008028772-A1 优先权日:2006-09-06 标 题:Bioquinones for stimulating keratin synthesis 发明人:GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS 权利人:HENKEL KGAA; GIESEN MELANIE; SCHULZE ZUR WIESCHE ERIK; POPPE ELISABETH; WELSS THOMAS 摘要:The present invention relates to the cosmetic use of one or more bioquinones for combating age-related changes in the hair follicles, for the promotion of keratin synthesis in the hair, and for positively influencing the structure of the hair. The invention further relates to a cosmetic method for combating age-related changes in the hair follicle, and to a method for stimulating keratin synthesis in hair.
专利号:JP-6275642-B2 优先权日:2011-08-16 标题:Enzymatic synthesis of optically active chiral amines
专利号:EP-1493431-B1 优先权日:2003-07-03 标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions 发明人:WIRTH CORINNA DR; BUCHHOLZ HERWIG DR 权利人:MERCK PATENT GMBH 摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.
专利号:WO-2006053688-A1 优先权日:2004-11-17 标 题:Cosmetic and dermatological preparations for the treatment of mature skin 发明人:DOERING THOMAS 权利人:HENKEL KGAA; DOERING THOMAS 摘要:The invention relates to topical cosmetic or dermatological compositions for the treatment of mature or intrinsically or extrinsically aged skin, in particular, for anti-wrinkle treatment, containing a combination of at least two selected peptides in a suitable cosmetic or dermatological vehicle, which have an effect at differing points of the process of collagen and/or fibronectin synthesis.
专利号:WO-2006042625-A2 优先权日:2004-10-15 标 题 :Compositions with inhibitors of the synthesis of prostaglandin and/or of leukotriene in conjunction with stimulators of the release of cutaneous neuromediators
1: Rosenberg J, Ischebeck T, Commichau FM. Vitamin B6 metabolism in microbes and approaches for fermentative production. Biotechnol Adv. 2017 Jan - Feb;35(1):31-40. doi: 10.1016/j.biotechadv.2016.11.004. Epub 2016 Nov 24. Review. Review. doi: 10.1016/j.bbapap.2010.12.006. Epub 2010 Dec 20. Review. Review. Review.
合成参考文献
摘要:de Kruijk JR, Notermans NC. [Sensory disturbances caused by multivitamin preparations]. Ned Tijdschr Geneeskd. 2005 Nov 12;149(46):2541–4. 摘要:Katan MB. [How much vitamin B6 is toxic ]. Ned Tijdschr Geneeskd. 2005 Nov 12;149(46):2545–6. 参考文献:10.1016/s0929-693x(11)71092-2 摘要:Roubertie A, Masson F, de Villepin-Touzery A, Suau B, Barbanel G, Rideau A, Cambonie G. [Neonatal seizures management]. Arch Pediatr. 2011 Jul;18 Suppl 2():S56–64. doi: 10.1016/s0929-693x(11)71092-2. 参考文献:10.1016/j.bbapap.2011.06.018 摘要:Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP. Pyridoxal phosphate: Biosynthesis and catabolism. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 2011 Nov;1814(11):1585–96. doi: 10.1016/j.bbapap.2011.06.018. 参考文献:10.1016/j.tvjl.2011.06.026 摘要:Galler A, Tran JL, Krammer-Lukas S, Höller U, Thalhammer JG, Zentek J, Willmann M. Blood vitamin levels in dogs with chronic kidney disease. The Veterinary Journal. 2012 May;192(2):226–31. doi: 10.1016/j.tvjl.2011.06.026.