CAS: 78191-00-1; N-Methoxy-N-Methylacetamide

相似化合物

104863-67-4 98-86-2 28077-64-7

欧盟法规

[ECHA物质

上下游产品

CAS号6638-79-5 二甲羟胺盐酸盐 | CAS号75-36-5 乙酰氯 | CAS号123-86-4 乙酸丁酯 | CAS号67442-07-3 2-氯-|N|-甲氧基-|N|... | CAS号64-19-7 冰醋酸 | CAS号3376-35-0 2-Propanone,O-m... | CAS号67-64-1 丙酮 | CAS号1117-97-1 甲氧基甲基胺 | CAS号1060805-69-7 1-(4-溴吡啶-2-基)乙酮 | CAS号5379-16-8 3,5-二甲基苯乙酮 | CAS号37687-18-6 1-(1-甲基-1H-吡唑-4-基)乙酮 | CAS号33021-53-3 3-乙酰基喹啉 | CAS号3900-45-6 6-甲氧基-2-乙酰萘 | CAS号5042-53-5 (苯基硫代)丙酮 | CAS号920036-27-7 1-(2,6-二氟吡啶-3-基)乙酮 | CAS号1817-61-4 non-4-yn-3-one | CAS号19986-25-5 2-Propanone, 1-... | CAS号79-16-3 N-甲基乙酰胺

2-氯-正甲氧基-正甲基乙酰胺置于3-羟基苯硫酚,Potassium Carbonate,四丁基碘化铵,Merrifield Resin,偶氮二异丁腈,三正丁基氢锡体系中,用 N,N-二甲基甲酰胺,氘代苯 作为反应溶剂,化学反应 4.17H,反应生成 N-甲氧基-N-甲基乙酰胺
参考文献:Radicicol(monorden)和pochonin C的溶液和固相合成.
标题:Radicicol(monorden)和pochonin C的溶液和固相合成.
摘要:报道了软骨素c和radicicol的模块化合成.两种天然产物分别从三个易得的片段中分七个步骤和八个步骤制备.这些化合物的替代合成是通过结合聚合物的试剂和固相反应实现的.研究了两种天然产物的构象,并通过2D NMR光谱进行了比较.
DOI:10.1002/chem.200500160

专利信息

专利号:US-2011130567-A1
优先权日:2009-06-03
标题 :Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; QU BO; YEE NATHAN K; RODRIGUEZ SONIA
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; n n R 2 and R 3 are each independently C 1 -C 5 alkyl; R 4 is C 1 -C 5 alkyl optionally independently substituted with one to three substituent groups,n wherein each substituent group of R 4 is independently C 1 -C 3 alkyl, hydroxy, halogen, amino, or oxo; and n R 5 is a heteroaryl group substituted with one to three substituent groups,n wherein each substituent group of R 5 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, alkylsulfonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, or C 1 -C 5 alkylthio wherein the sulfur atom is optionally oxidized to a sulfoxide or sulfone.

专利号:US-7348436-B2
优先权日:2004-03-02
标题 :Compounds useful for the synthesis of (+)-discodermolide and methods thereof
发明人：MYLES DAVID C; SHAW SIMON JAMES; SUNDERMANN KURT F
权利人:KOSAN BIOSCIENCES INC
摘要:Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.

专利号:US-2011130578-A1
优先权日:2009-06-03
标题 :Stereoselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; KUZMICH DANIEL; REEVES JONATHAN T; SONG JINHUA J; TAN ZHULIN; LEE THOMAS
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, C 2 -C 5 alkenyl, C 2 -C 5 alkynyl, C 1 -C 5 alkoxy, C 1 -C 5 alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, C 1 -C 5 alkoxycarbonylamino, aminosulfonyl, C 1 -C 5 alkylaminosulfonyl, C 1 -C 5 dialkylaminosulfonyl, halogen, hydroxy, carboxy, cyano, trifluoromethyl, trifluoromethoxy, nitro, or C 1 -C 5 alkylthio wherein the sulfur atom is oxidized to sulfoxide or sulfone, and n R 2 and R 3 are each independently hydrogen or C 1 -C 5 alkyl.

专利号:WO-9746543-A1
优先权日:1996-05-31
标题:Acetyl derivatives of thiazoles and analogues
发明人：PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
权利人:UNIV WOLLONGONG; PYNE STEPHEN GEOFFREY; UNG ALISON THAVARY
摘要:The present invention is directed to compounds useful in the treatment of autoimmune diseases and inflammatory diseases of general formula (I) wherein R1 is alkyl, alkenyl or alkynyl having from 1 to 6 carbons, phenyl, benzyl or phenethyl; R2 is H, C1 to C5 alkyl which can optionally be partially hydroxylated or the group (a) wherein n is from 0 to 4; and X, Y and Z are independently CH, N, NH, O or S, or a pharmaceutically acceptable ester or acid addition salt thereof, or a stereoisomer or a geometric isomer thereof, with the proviso that at least one of X, Y or Z is CH, that one and only one of X, Y and Z is NH, O or S and further that when Y is N or NH then Z is not N or NH. The present invention is also concerned with processes for the synthesis of the compounds and with methods of use of the compounds.

专利号:US-9776966-B2
优先权日:2011-03-03
标 题:Synthesis of 2-carboxamide cycloamino urea derivatives
发明人：ERB BERNHARD; GALLOU ISABELLE SYLVIE; KLEINBECK FLORIAN KARL
权利人:NOVARTIS AG
摘要:Provided herein are processes and intermediate compounds useful for the preparation of 2-carboxamide cycloamino urea derivatives, and useful intermediates therefore.

专利号:US-7521478-B2
优先权日:2002-07-30
标 题 :Total synthesis of myriaporones
发明人：DEL POZO LOSADA CARLOS; FRANCESCH ANDRES; MARCHANTE CARMEN CUEVAS; ALVAREZ MARTA PEREZ
权利人:PHARMA MAR SAU
摘要:Compounds of the general formula (I) or a pharmaceutically acceptable salt, derivative, prodrug or stereoisomer thereof are provided: wherein the substituent groups defined by R are each independently selected from the group consisting of H, SiR′ 3 , SOR′, SO 2 X, C(â•?O)R′, C(â•?O)OR′, C(â•?O)NR′, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aryl, heteroaryl or aralkyl; the group R′ is selected from substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, aminoalkyl, aryl, aralkyl and heterocyclic groups; and the group R″ is selected from the group consisting of H, OH, OR′, OCOR′, SH, SR′, SOR′, SO 2 R′, NO 2 , NH 2 , NHR′, N(R′) 2 , NHCOR′, N(COR′) 2 , NHSO 2 R′, CN, halogen, C(â•?O)H, C(â•?O)R′, CO 2 H, CO 2 R′, CH 2 OR, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkylidene, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and substituted or unsubstituted heteroaromatic; with the proviso that the compound is not compound 1, 3 or 4 of U.S. Pat.No. 5,514,708. The compounds have antitumour activity. A synthetic route is also provided.