CAS: 75178-87-9; Tert-Butyl (4-Hydroxybutyl)Carbamate

相似化合物

13325-10-5 42042-68-2 99207-32-6

上下游产品

CAS号13325-10-5 4-氨基-1-丁醇 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号85909-08-6 N-B°C-2-吡咯烷酮 | CAS号2508-29-4 5-氨基-1-戊醇 | CAS号57294-38-9 N-B°C-γ-氨基丁酸 | CAS号104700-36-9 ethyl (2E)-4-((... | CAS号67-56-1 甲醇 | CAS号67-63-0 异丙醇 | CAS号33545-98-1 B°C-1,4-丁二胺盐酸盐 | CAS号262278-40-0 (4-碘丁基)氨基甲酸叔丁酯 | CAS号85909-08-6 N-B°C-2-吡咯烷酮 | CAS号68076-36-8 N-(叔丁氧羰基)-1,4-丁二胺 | CAS号129392-85-4 (4-叠氮丁基)氨基甲酸叔丁酯 | CAS号174626-25-6 4-[(2-methylpro... | CAS号164365-88-2 4-(B°C-氨基)丁基溴 | CAS号73286-71-2 N-B°C-2-吡咯啉 | CAS号68076-40-4 tert-butyl N-[4... | CAS号84766-90-5 N-(4-氧代丁基)氨基甲酸叔丁酯

4-氨基-1-丁醇置于三乙胺体系中,用76%的收率获得产物4-(N-叔丁氧羰基氨基)-1-丁醇
参考文献:Target Protein Eed Degradation-Inducing Degraducer,Preparation Method Thereof,And Pharmaceutical Composition For Preventing Or Treating Diseases Related To Eed,Ezh2,Or Prc2,Comprising Same As Active Ingredient
标题:Target Protein Eed Degradation-Inducing Degraducer,Preparation Method Thereof,And Pharmaceutical Composition For Preventing Or Treating Diseases Related To Eed,Ezh2,Or Prc2,Comprising Same As Active Ingredient
摘要:本发明涉及一种靶蛋白降解诱导剂degraducer,其制备方法以及包含其作为活性成分的用于预防或治疗与eed,Ezh2或prc2相关疾病的药物组合物.根据本发明,由式1表示的一种新化合物是一种degraducer化合物,通过利用cereblon E3泛素连接酶,Von Hippel-Lindau肿瘤抑制因子(vhl)e3泛素连接酶,鼠双分钟2同源物(mdm2)e3泛素连接酶和细胞凋亡抑制蛋白1(ciap)e3泛素连接酶诱导靶蛋白,即胚胎外胚层发育(eed)或多能复合体抑制2(prc2)的降解,其中该化合物通过泛素蛋白酶体系统(ups)显著实现靶蛋白降解诱导活性的方面,因此可以提供一种用于预防或治疗与靶蛋白相关疾病或症状的药物组合物,以及包含所述化合物作为活性成分的功能性保健食品组合物,具有有益效果.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-12337036-B2
优先权日:2018-01-01
标题:Compounds and methods for trans-membrane delivery of molecules
发明人：ZIV ILAN; GRIMBERG HAGIT; DUBROVSKY JOSEPH
权利人:APOSENSE LTD
摘要:The Invention provides a novel delivery system for delivery of drugs across biological membranes. It provides novel chemical conjugates that comprise said delivery system, methods for synthesis of said compounds, and methods for utilization of said delivery system, among others, for delivery of genetic drugs into tissues and cells, in vitro, ex vivo, and in vivo, for the treatment of various medical disorders.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人：ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:WO-2024216075-A1
优先权日:2023-04-13
标题 :Synthesis of mavorixafor and intermediates thereof
发明人：SEKIRNIK ANGELINA ROBERTA; TAVERAS ART; GAO FENG; ZHAO ZHIGANG
权利人:X4 PHARMACEUTICALS INC
摘要:The present invention relates to methods for synthesizing C-X-C receptor type 4 (CXCR4) inhibitor mavorixafor and to intermediates thereto.

专利号:US-7491727-B2
优先权日:2003-01-31
标题:Arylpiperazinyl compounds
发明人：DHANOA DALE S; CHEN DONGLI; BECKER OREN; NOIMAN SILVIA; CHERUKU SRINIVASA R; MARANTZ YAEL; SHARADENDU ANURAG; SHACHAM SHARON; HEIFETZ ALEXANDER; MOHANTY PRADYUMNA; INBAL BOAZ; FICHMAN MERAV; NUDELMAN RAPHAEL; BAR-HAIM SHAY
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists or antagonists. Novel arylpiperazinyl sulfonamide compounds represented by Formula I, and synthesis and uses thereof for treating diseases including those mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include central nervous system disorders such as generalized anxiety disorder, ADD/ADHD, neural injury, stroke, and migraine. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.