CAS: 74863-82-4; 3-Methyl-8-Quinolinesulphonyl Chloride

相似化合物

18704-37-5 21863-51-4 13982-84-8

上下游产品

CAS号612-58-8 3-甲基喹啉 | CAS号74863-84-6 阿加曲班(MCI-9038)

3-甲基-8-喹啉磺酸置于三光气,三乙胺体系中,用 甲苯 作为反应溶剂,化学反应 3.0H,以178 G的收率获得产物3-甲基-8-喹啉磺酰氯
参考文献:3-甲基喹啉-8-磺酰氯的制备方法
标题:3-甲基喹啉-8-磺酰氯的制备方法
摘要:本发明属精细化工产品生产领域,特别涉及一种3‑甲基喹啉‑8‑磺酰氯的制备方法,包括如下步骤:(1)以2‑氨基苯磺酸为起始原料,通过与丙醛和多聚甲醛在低共熔溶剂中的催化环化得到3‑甲基喹啉‑8‑磺酸;(2)以二(三氯甲基)碳酸酯为氯化剂,在有机碱作用下对反应生成的3‑甲基喹啉‑8‑磺酸进行酰氯化,从而得到3‑甲基喹啉‑8‑磺酰氯.本发明操作过程简便,原料易得,成本低,并在整个工艺过程无有害气体产生,符合安全和环保要求,有利于规模化生产.

专利信息

专利号:US-7015176-B2
优先权日:2003-06-03
标题 :Process for the synthesis of aryl sulfurpentafluorides
发明人：BAILEY III WADE H; CASTEEL JR WILLIAM J; PESARESI RENO J; PROZONIC FRANK M
权利人:AIR PROD & CHEM
摘要:A process is described for the synthesis of an aryl sulfur pentafluoride compound. In one embodiment of the present invention, there is provided a process for preparing an aryl sulfurpentafluoride compound comprising: combining an at least one aryl sulfur compound with a fluorinating agent to at least partially react and form an intermediate aryl sulfurtrifluoride product; and exposing the intermediate aryl sulfurtrifluoride product to the fluorinating agent and optionally a fluoride source to at least partially react and form the aryl sulfurpentafluoride compound.

专利号:WO-9740052-A1
优先权日:1996-04-22
标题 :Propagylglycine derivatives, preparation and utilisation thereof as synthesis intermediates
发明人：CARDINAUD ISABELLE; CHEKROUN ISAAC; ROSSEY GUY; CREMER GERARD; GOBERVILLE PASCALE; HOORNAERT CHRISTIAN
权利人:SYNTHELABO; CARDINAUD ISABELLE; CHEKROUN ISAAC; ROSSEY GUY; CREMER GERARD; GOBERVILLE PASCALE; HOORNAERT CHRISTIAN
摘要:Compounds of formula (I) wherein R2 is -CH2C=CH or -CH2C=C-Het where Het is a 2-aminopyridyl, 2-aminopyrimidyl, 6-aminopyridazinyl, imidazol-4-yl group, R3 and R4 each represent hydrogen, (C1-C4)alkyl, (C1-C4)alkoxycarbonyl, ArCH2CO2- or ArSO2- where Ar is an aryl group, or a group (a) where R7 is hydrogen or -COR, R being straight or branched (C1-C7) alkyl, -(CH2)nOCH3 or -CH2O(C2H4O)nCH3 (n is 1, 2 or 3) and A is chosen among the phenyl, pyrimidyl, pyridinyl, thienyl, thiazolyl and furyl groups, R6 represents either a straight or branched (C1-C4) alkoxy group, or a benzyloxy group or a group (b) where R12 is a hydrogen atom or a carboxylic or (C1-C4)alkoxycarbonyl group and R13 is a straight or branched (C1-C4)alkyl group. They constitute synthesis intermediates.

专利号:EP-1484318-A1
优先权日:2003-06-03
标题:Process for the synthesis of aryl sulfurpentafluorides

专利号:WO-0158872-A1
优先权日:2000-02-09
标题 :Method for diastereoselective preparation of piperidines functionalised in positions 2 and 4 for use as synthesis intermediates

专利号:CN-113563417-A
优先权日:2021-07-16
标题 :A kind of continuous flow synthesis method of argatroban intermediate

专利号:FR-2804682-A1
优先权日:2000-02-09
标 题:DIASTEREOSELECTIVE PREPARATION PROCESS OF PIPERIDINES FUNCTIONALIZED IN POSITIONS 2 AND 4 USABLE AS SYNTHESIS INTERMEDIARIES