专利号:US-2007010691-A1 优先权日:2003-07-02 标 题:Enantioselective synthesis of enantiomerically enriched compounds 发明人:PICCOLO ORESS; ULGHERI FAUSTA; MARCHETTI MAURO 权利人:CONSIGLIO NAZIONALE RICERCHE 摘要:Method of preparing an enantiomerically enriched compound of formula (II) comprising enantioselective hydrogenation of a compound of general formula (I): where W, X and Z have the meanings indicated in the description, to give a compound of general formula (II): where W, Y, T and C* have the meanings indicated in the description, in the presence of a catalyst or its suitable precursor based on Rh, Ru or Ir, having an oxidation state of 0, +1 or +2, and containing at least one enantiomerically enriched chiral ligand.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-4161609-A 优先权日:1977-09-14 标题:Synthesis of carboxylic acid esters 发明人:CRAMER RICHARD D 权利人:DU PONT 摘要:A method is provided for converting a carboxylic acid amide to a carboxylic acid ester by reacting a vaporized mixture of the amide and an aliphatic alcohol or a phenol in the presence of a suitable catalyst at temperatures of from 100 DEG C. to 400 DEG C. The process is especially useful for the conversion of methacrylamide to methyl methacrylate.
专利号:WO-2024052739-A1 优先权日:2022-09-08 标 题 :Method for the synthesis of benzodioxepinone compounds and intermediates thereof 发明人:NANDAN DR SANTOSH RAGHU; KORI AMITKUMAR RAMBIHARI; SHARMA BASANTKUMAR RAJKUMAR; SATISH SOHAL; CHITRAL ROHAN KAILASH; S JAYASHREE PUTTUR 权利人:AMBERNATH ORGANICS PVT LTD 摘要:A method for the preparation of benzodioxepinone compounds of formula (I), and the intermediates thereof, wherein, R 1 is independently selected from the group consisting of hydrogen, halogen, C 1 -C 6 alkyl, C 2 - C 6 alkenyl and C 3 -C 6 cycloalkyl; n represents integer 0-3.
专利号:US-2007099919-A1 优先权日:2005-10-06 标题 :Composition and synthesis of new reagents for inhibition of HIV replication
专利号:WO-2018129235-A1 优先权日:2017-01-06 标 题 :Synthesis of benzyloxyphenoxy phenol ligands