CAS: 66211-46-9; (R)-3-Aminopropane-1,2-Diol

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167700-44-9 148983-25-9 137618-48-5

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CAS号616-30-8 3-氨基-1,2-丙二醇 | CAS号60456-23-7 (S)-缩水甘油 | CAS号22195-47-7 2,2-二甲基-1,3-二氧戊... | CAS号122697-84-1 (2R,5R)-2-(tert...

Ethyl (2R,1'R)-2-Acetyloxy-3-(1'-Phenylethyl)Aminopropionate置于palladium Dihydroxide 二碳酸二叔丁酯,氢气,Lithium Aluminium Tetrahydride,盐酸体系中,用 甲醇,四氢呋喃 作为反应溶剂,化学反应 13.0H,以29 Mg的收率获得产物(R)-3-氨基-1,2-丙二醇
参考文献:Ring Opening Of 2-Acylaziridines By Acid Chlorides
标题:Ring Opening Of 2-Acylaziridines By Acid Chlorides
摘要:Good Nucleophilicity Of The Ring Nitrogen In Chiral (2R,1'R)-2-Acyl-(1'-Phenylethyl)Aziridines Initiated The Reaction With Various Acid Chlorides To Form The Corresponding Acylaziridinium Ion Intermediates Whose Rings Were Opened By The Chloride Anion To Yield The Beta-Amino-Alpha-Chlorocarbonyl Compounds. The Subsequent Displacement Of The Chloride With The Internal Oxygen Nucleophile Originated From Methylchloroformate,Acetyl Chloride,And Methyl Chlorooxoacetate Yielded Oxazolidin-2-Ones,Beta-Amino-Alpha-Acetyloxypropionates,And Morpholin-2,3-Diones,Respectively. (C) 2006 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Tet.2006.06.025

专利信息

专利号:US-2024209018-A1
优先权日:2021-03-22
标题:Universal linker reagents for dna synthesis
发明人：REED MICHAEL W; WU CHENG-HSIEN; COOPER JOHN; DEMPCY ROBERT O
权利人:GENSCRIPT USA INC; CUSTOMARRAY INC
摘要:Provided herein are methods and compositions for oligonucleotide synthesis utilizing universal linker phosphoramidites. Methods and reagents are described with DNA synthesis using controlled pore glass (CPG) solid supports, and on platinum coated electrodes for electrochemical DNA synthesis. The universal linkers can be used as spacers in single-column PCR primer synthesis to generate 2 strands with free 3′-hydroxy termini after cleavage. The methods and compositions utilize a solid support system for synthesis of oligonucleotides, wherein the support has platinum electrodes and a universal linker, optionally wherein the platinum electrode is coated with an amine. The methods and compositions further describe use of universal linker phosphoramidites and the platinum electrode is coated with a monosaccharide, or a disaccharide.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-4352788-A
优先权日:1979-08-09
标题 :Derivatives of 2,4,6-triiodo-isophthalic acid, processes for their synthesis and X-ray contrasting materials containing these
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:Compounds for use in non-ionic X-ray contrasting materials having the formula ##STR1## in which (H0) 2-3 alkyl is 1,3-dihydroxyisopropyl, 2,3-dihydroxypropyl or 1,3-dihydroxy-2-hydroxymethylisopropyl, n R is hydrogen or methyl, and n R 1 is an alkyl residue with 1 to 5 carbon atoms. n These compounds possess high water-solubility as well as excellent stability against hydrolysis. Methods for preparation and use of the compounds are also disclosed.

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-4348377-A
优先权日:1979-08-09
标题:New derivatives of 2,4,6-triiodo-isophthalic acid, proceses for their synthesis and X-ray contrasting materials containing these
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:Novel, radio-opaque compounds comprising water-soluble bis-[N-{3,5-bis-(hydroxyalkylaminocarbonyl)-2,4,6-triiodo-phenyl}-N-( alpha -hydroxyacyl)-amino]-alkanes are disclosed for use as X-ray contrast agents. These compounds are relatively simple to synthesize, possess low toxicity and have good stability as well as resistance to hydrolysis. Methods for preparation and use of the compounds are also disclosed.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.