CAS: 61424-26-8; 3-Benzylaniline

上下游产品

CAS号5840-41-5 1-benzyl-3-nitr... | CAS号619-23-8 间硝基氯化苄 | CAS号141883-38-7 N-[(2-chloro-5-... | CAS号2243-80-3 3-硝基二苯甲酮 | CAS号619-25-0 3-硝基苯甲醇 | CAS号71-43-2 苯 | CAS号7647-01-0 盐酸 | CAS号261-31-4 噻吨 | CAS号120454-34-4 2-benzylbenzenethiol | CAS号55251-23-5 N-(3-benzylphen... | CAS号63021-27-2 Acetamide,N-[3-... | CAS号634186-29-1 N-(3-benzylphen...

📜1-苄基-3-硝基苯置于盐酸,铁粉体系中,用 乙醇,水 作为反应溶剂,以94 %的收率获得产物3-苯甲基苯胺
参考文献:开发 Lm-41 和 Af-2112,这两种氟芬那酸衍生的 Tead 抑制剂,通过芳环取代三氟甲基而获得
标题:开发 Lm-41 和 Af-2112,这两种氟芬那酸衍生的 Tead 抑制剂,通过芳环取代三氟甲基而获得
摘要:Hippo 通路通过控制细胞增殖和凋亡来调节器官大小和组织稳态.yap-Tead 转录因子是 Hippo 通路的下游效应子,调节ctgf,Cyr61,Axl和nf2等基因的表达.已在多种癌症中发现异常的 Hippo 活性.据报道,氟芬那酸 (Fa) 结合在亲脂性 Tead 棕榈酸 (Pa) 口袋中,导致axl和nf2表达减少.在这里,我们表明,用芳香族基团取代 Fa 中的三氟甲基部分,直接连接到支架或通过接头分开,可以产生与 Tead 具有更好亲和力的化合物.共结晶研究表明,这些化合物与 Fa 的结合方式类似,但在 Pa 口袋的深处.我们的研究确定 Lm-41 和 Af-2112 是两种 Tead 结合剂,可强烈降低ctgf,Cyr61,Axl和nf2的表达.lm-41 对人类 Mda-Mb-231 乳腺癌细胞的迁移具有最强的抑制作用.
DOI:10.1016/j.Bmcl.2023.129488

专利信息

专利号:US-7425650-B1
优先权日:2004-07-23
标 题 :Synthesis of asymmetric tetracarboxylic acids and corresponding dianhydrides
发明人：CHUANG CHUN-HUA
权利人:NASA
摘要:This invention relates to processes for preparing asymmetrical biphenyl tetracarboxylic acids and the corresponding asymmetrical dianhydrides, namely 2,3,3′,4′-biphenyl dianhydride (a-BPDA), 2,3,3′,4′-benzophenone dianhydride (a-BTDA) and 3,4′-methylenediphthalic anhydride (-MDPA). By cross-coupling reactions of reactive metal substituted o-xylenes or by cross-coupling o-xylene derivatives in the presence of catalysts, this invention specifically produces asymmetrical biphenyl intermediates that are subsequently oxidized or hydrolyzed and oxidized to provide asymmetric biphenyl tetracarboxylic acids in comparatively high yields. These asymmetrical biphenyl tetracarboxylic acids are subsequently converted to the corresponding asymmetrical dianhydrides without contamination by symmetrical biphenyl dianhydrides.

专利号:US-10458995-B2
优先权日:2016-03-25
标 题 :Combinatorial synthesis and biomarker development
发明人：MOOLA MURALIDHAR REDDY
权利人:MOOLA MURALIDHAR REDDY
摘要:Provided herein are methods, kits, and compositions for use in the diagnosis and treatment of diseases. Peptoids recognized by Alzheimers disease specific antibodies are identified.

专利号:US-8378104-B2
优先权日:2010-02-11
标 题 :7-aminofuropyridine derivatives
发明人：HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
权利人:OSI PHARMACEUTICALS LLC; HORNBERGER KEITH R; BERGER DAN M; CHEN XIN; CREW ANDREW P; DONG HANQING; KLEINBERG ANDREW; LI AN-HU; MA LIFU; MULVIHILL MARK J; PANICKER BIJOY; SIU KAM W; STEINIG ARNO G; TARRANT JAMES G; WANG JING; WENG QINGHUA; SANGEM RAJARAM; GUPTA RAMESH C
摘要:Compounds of Formula 1, as shown below and defined herein: n n n n n n n n n n n n pharmaceutically acceptable salts thereof, synthesis, intermediates, formulations, and methods of disease treatment therewith, including treatment of cancers, such as tumors driven at least in part by TAK1 or for which an appropriate TAK1 inhibitor is effective. This Abstract is not limiting of the invention.

专利号:CN-119661386-A
优先权日:2024-12-04
标 题:Synthesis method and compound of 3-amino-5- (4-methoxybenzyl) -2-nitrobenzoic acid methyl ester