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参考文献:Sar Studies Of Capsazepinoid Bronchodilators. Part 1: The Importance Of The Catechol Moiety And Aspects Of The B-Ring Structure
标题:Sar Studies Of Capsazepinoid Bronchodilators. Part 1: The Importance Of The Catechol Moiety And Aspects Of The B-Ring Structure
摘要:Capsazepine As Well As Its Derivatives And Analogues Are General Inhibitors Of Constriction Of Human Small Airways. From A Systematic Variation Of The Capsazepine Structure,Divided Into Four Regions,Sars Were Established. This Part Concerns The Catechol Moiety Of The A-Ring As Well As The 2,3,4,5-Tetrahydro-1H-2-Azepine Moiety (The B-Ring) Of Capsazepine. It Is Revealed That A Conformational Constrain (As A Fused Ring) Is Important And That Compounds With A Six-Membered B-Ring (As A 1,2,3,4-Tetrahydroisoquinoline) In General Are More Potent Than The Corresponding Isoindoline,2,3,4,5-Tetrahydro-1H-2-Benzazepi Ne And 2,3,4,5-Tetrahydro-1H-3-Benzazepine Derivatives. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmc.2007.11.055