CAS: 59709-57-8; 1-Methyl-1,2,3,4-Tetrahydroisoquinoline-6,7-Diol Hydrobromide

该化合物是一种化学化合物,属于四氢硫素类,是双环有机化合物,该物质具有四氢硫基核,在6和7个位置上有两个氢氧基(-OH)组,在1个位置上有一个甲基组,有助于其独特的特性.氢溴化盐形式表明它与氢溴酸结合,提高了其在水中的溶解性,使之适合各种用途,特别是在生物和制药方面.氢氧基组的存在表明氢联结的潜力,这可能影响其再活动以及与生物分子的相互作用.该化合物可能会出现多种药理活动,尽管具体的生物影响取决于进一步的研究.与许多有机化合物一样,应观测安全和处理预防措施,特别是由于其分类和潜在生物影响.

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欧盟法规

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CAS号63283-42-1 6,7-二甲氧基-1-甲基-1... | CAS号621-84-1 氨基甲酸苄酯 | CAS号38221-21-5 6,7-二羟基-1-甲基-1,...

合成工艺路线路线简述

    📜6,7-二甲氧基-1-甲基-1,2,3,4-四氢异喹啉置于氢溴酸体系中,化学反应 5.0H,以100%的收率获得产物氢溴酸去甲猪毛菜碱
    参考文献:Sar Studies Of Capsazepinoid Bronchodilators. Part 1: The Importance Of The Catechol Moiety And Aspects Of The B-Ring Structure
    标题:Sar Studies Of Capsazepinoid Bronchodilators. Part 1: The Importance Of The Catechol Moiety And Aspects Of The B-Ring Structure
    摘要:Capsazepine As Well As Its Derivatives And Analogues Are General Inhibitors Of Constriction Of Human Small Airways. From A Systematic Variation Of The Capsazepine Structure,Divided Into Four Regions,Sars Were Established. This Part Concerns The Catechol Moiety Of The A-Ring As Well As The 2,3,4,5-Tetrahydro-1H-2-Azepine Moiety (The B-Ring) Of Capsazepine. It Is Revealed That A Conformational Constrain (As A Fused Ring) Is Important And That Compounds With A Six-Membered B-Ring (As A 1,2,3,4-Tetrahydroisoquinoline) In General Are More Potent Than The Corresponding Isoindoline,2,3,4,5-Tetrahydro-1H-2-Benzazepi Ne And 2,3,4,5-Tetrahydro-1H-3-Benzazepine Derivatives. (C) 2007 Elsevier Ltd. All Rights Reserved.
    DOI:10.1016/j.Bmc.2007.11.055

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    专利信息


    专利号:RU-2195454-C2
    优先权日:1996-10-18
    标 题 :Derivatives of anthranilic acid, methods of their synthesis and pharmaceutical composition based on thereof

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/978-1-4939-9438-0_11
    摘要:Hellinghausen G, Armstrong DW. Cyclofructans as Chiral Selectors: An Overview. Methods Mol Biol. 2019;1985():183–200. doi: 10.1007/978-1-4939-9438-0_11.
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