CAS: 55916-52-4; (2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3R,4S,5S,6R)-4-Hydroxy-2-(((4S,5'R,6Ar,6Bs,8As,8Bs,9S,10R,11As,12As,12Br)-8B-Hydroxy-5',6A,8A,9-Tetramethyl-1,3,3',4,4',5,5',6,6A,6B,6',7,8,8A,8B,9,11A,12,12A,12B-Icosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,5-Diyl)Bis(Oxy))Bis(2-Methyltetrahydro-2H-Pyran-3,4,5-Triol)

该化合物是一种血清盐质衍生物,其结构特征是C-3位置上的苯丙胺丙烯丙烯基酮与该物质相连,该化合物具有显著的生物活性,特别是在调制细胞信号路径和展示潜在药理效应,包括抗炎和抗癌特性方面,其独特的相联性模式会增加溶性,增加生物利用率,使其成为生物医学研究的宝贵对象.该化合物因其结构特性和与生物目标的相互作用,对植物化学和药物发现很感兴趣.

英文名称(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3R,4S,5S,6R)-4-Hydroxy-2-(((4S,5'R,6Ar,6Bs,8As,8Bs,9S,10R,11As,12As,12Br)-8B-Hydroxy-5',6A,8A,9-Tetramethyl-1,3,3',4,4',5,5',6,6A,6B,6',7,8,8A,8B,9,11A,12,12A,12B-Icosahydrospiro[naphtho[2',1':4,5]Indeno[2,1-B]Furan-10,2'-Pyran]-4-yl)Oxy)-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-3,5-Diyl)Bis(Oxy))Bis(2-Methyltetrahydro-2H-Pyran-3,4,5-Triol)
中文名称偏诺皂苷元-3-O-α-L-吡喃鼠李糖-(1→4)[α-L-吡喃鼠李糖基](1→2)-β-D-葡萄糖苷
IUPAC名称(2S,2'S,3R,3'R,4R,4'R,5R,5'R,6S,6'S)-6,6'-(((2R,3R,4S,5S,6R)-4-hydroxy-2-(((4S,5'R,6aR,6bS,8aS,8bS,9S,10R,11aS,12aS,12bR)-8b-hydroxy-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diyl)bis(oxy))bis(2-methyltetrahydro-2H-pyran-3,4,5-triol)
其它别名Pennogenin3-O-α-L-Rhamnopyranosyl-(1→2)-[α-L-Rhamnopyranosyl-(1→4)]-β-D-Glucopyranoside; (25R)-17Alpha-Hydroxyspirost-5-En-3Beta-Yl Alpha-L-Rhamnopyranosyl-(1->2)-[alpha-L-Rhamnopyranosyl-(1->4)]-Beta-D-Glucopyranoside; Pennogenin 3-O-Beta-Chacotrioside; Pennogenin-3-O-α-L-Rhamnopyranosyl-(1→4)-[α-L-Rhamnopyranosyl-(1→2)]-β-D-Glucopyranoside; -Rhamnopyranosyl-(1→2)]-β-D-Glucopyranoside; Inhibit,Autophagy,Pennogenin 3Obetachacotrioside,Inhibitor,Pennogenin 3 O Beta Chacotrioside; β-D-Glucopyranoside, (3β,25R)-17-Hydroxyspirost-5-En-3-Yl O-6-Deoxy-α-L-Mannopyranosyl-(1→2)-O-[6-Deoxy-α-L-Mannopyranosyl-(1→4)]-; Pennogenin 3-O-Beta-Chacotrioside, 10 Mm In Dmso
CAS编号55916-52-4
MFCD编号:MFCD31747001
分子式:C45H72O17分子量:885.05
产品CID: 1531250
产品分类生物化工 → 提取物 → 植物提取物

相似结构搜索
产品信息参考;;;;
InChIKey: NABPSKKFOWENEB-KUYDPMQHSA-N
InChI=1S/C45H72O17/c1-19-9-14-44(55-18-19)22(4)45(54)29(62-44)16-27-25-8-7-23-15-24(10-12-42(23,5)26(25)11-13-43(27,45)6)58-41-38(61-40-35(52)33(50)31(48)21(3)57-40)36(53
计算化学: 氢键受体数17.0氢键供体数9.0可旋转键数7.0

MSDS等安全信息

上下游产品

26-O-β-D-Glucopyranosyl-(22ψ,25R)-Furost-5-Ene-3β,17α,22,26-Tetraol 3-O-α-L-Rhamnopyranosyl-(1->2)-[o-α-L-Rhamnopyranosyl-(1->4)]-O-β-D-Glucopyranoside

合成工艺路线路线简述

📜26-O-β-D-Glucopyranosyl-(22ψ,25R)-Furost-5-Ene-3β,17α,22,26-Tetraol 3-O-α-L-Rhamnopyranosyl-(1->2)-[o-α-L-Rhamnopyranosyl-(1->4)]-O-β-D-Glucopyranoside置于glycosidase体系中,用水作为反应溶剂,化学反应 3.0H,以15 Mg的收率获得产物d-葡萄糖
参考文献:Steroid Saponins And Sapogenins Of Underground Parts Of Trillium Kamtschaticum Pall. Iv. Additional Oligoglycosides Of 18-Norspirostane Derivatives And Other Steroidal Constituents.
标题:Steroid Saponins And Sapogenins Of Underground Parts Of Trillium Kamtschaticum Pall. Iv. Additional Oligoglycosides Of 18-Norspirostane Derivatives And Other Steroidal Constituents.
摘要:从延龄草地下部分分离得到3个18-去甲螺旋甾烷衍生物三糖甙ty-2,Ty-3和ty-4及2个甾体化合物tm和tj.以前得到的但是未被鉴定的2个甾体化合物th和tz乙酸酯也可被鉴定.其鉴定结果如下:Ty-2,熔点235-240°(分解),[α]_d-110°:异延龄草皂甙a (ⅱ) (延龄草皂甙b).ty-3,熔点182-185°(分解),[α]_d-98.7°:3,21-二-O-乙酰基-24-表延龄皂甙元1-O-(2',3',4'-三-O-乙酰基-α-L-吡喃鼠李糖)-(1->2)-α-L-吡喃阿拉伯糖甙 (ⅳ) (表延龄草皂甙c-Pa).ty-4,熔点226-230°(分解),[α]_d-105°:21-去氧延龄草皂甙a (ⅶ) (去氧延龄草皂甙a).tm,熔点326-329°(分解),[α]_d-99.4°:24β-羟基蚱蜢甾酮 (ⅴ).tj,熔点205-212°(分解),[α]_d-66.5°:蚱蜢甾酮3-O-β-查可三糖甙原型化合物 (ⅷ).th,熔点194-200°(分解),[α]_d-90°:蚱蜢甾酮3-O-α-L-吡喃鼠李糖-β-查可三糖甙原型化合物 (ⅸ).tz乙酸酯:乙基蜕皮甾酮三乙酸酯粗品 (ⅹ).除了化合物ⅸ,ⅹ以外,其它化合物在自然界中的发现尚属首次.特别是化合物ⅳ的出现引起了人们极大的兴趣.在此之前人们曾预测在相应的蚱蜢甾酮糖甙中共存ⅷ和ⅸ型化合物.
DOI:10.1248/cpb.29.325