CAS: 525-82-6; 2-Phenyl-4H-Chromen-4-One

该化合物是属于植物王国广泛分布的被称为氟氯素的化合物类别,其特征为黄色晶状,其分子式为C15H10O2. 氟拉夫内具有铬骨质,由苯环组成,并会助长其芳香特性的倍罗内环组成.该化合物以其抗氧化,抗炎和潜在的抗癌活动而闻名,使其在药理研究中引起兴趣.氟拉夫内在乙醇和乙醇等有机溶剂中溶解,但水溶性有限.其结构允许各种替代,导致不同生物活动的各种衍生物.此外,氟拉夫内还存在于各种植物中,有助于其颜色和健康效益.其在植物代谢和潜在治疗应用中的作用仍然是生物化学和药理学领域的积极研究领域.

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CAS号65-85-0 苯甲酸 | CAS号118-93-4 邻羟基苯乙酮 | CAS号98-86-2 苯乙酮 | CAS号69-72-7 水杨酸

合成工艺路线路线简述

    2-(Benzoyloxy)-Benzoylmethyltriphenylphosphonium Bromide置于三乙胺体系中,用 水 作为反应溶剂,化学反应 0.58H,以86%的收率获得产物黄酮
    参考文献:分子内光化学wittig反应在水中合成黄酮和吡喃黄酮
    标题:分子内光化学wittig反应在水中合成黄酮和吡喃黄酮
    摘要:朝向黄酮和pyranoflavone的合成的新的合成方法已被开发通过光诱导的分子内光化学维悌希反应在水到芳氧基羰基和适当取代的鏻溴化物sans任何相转移催化剂或助催化剂.
    DOI:10.1016/j.Tetlet.2011.10.134

    海关参考信息

    专利信息


    专利号:US-6770436-B1
    优先权日:1996-11-14
    标题:Chemical amplification for the synthesis of patterned arrays
    发明人:BEECHER JODY E; GOLDBERG MARTIN J; MCGALL GLENN H
    权利人:AFFYMETRIX INC
    摘要:Radiation-activated catalysts (RACs), autocatalytic reactions, and protective groups are employed to achieve a highly sensitive, high resolution, radiation directed combinatorial synthesis of pattern arrays of diverse polymers. When irradiated, RACs produce catalysts that can react with enhancers, such as those involved in autocatalytic reactions. The autocatalytic reactions produce at least one product that removes protecting groups from synthesis intermediates. This invention has a wide variety of applications and is particularly useful for the solid phase combinatorial synthesis of polymers.

    专利号:WO-2020032913-A1
    优先权日:2018-08-04
    标题:Process for synthesis of oroxylin a
    发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI
    权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA
    摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalm is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A gluciironide methyl ester which on de- glycosylation results in the formation of Oroxylin A.

    专利号:WO-2025081225-A1
    优先权日:2023-10-17
    标 题 :Synthesis of polyphenols
    发明人:TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
    权利人:Delica Therapeutics Pty Ltd
    摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

    专利号:US-7951961-B2
    优先权日:2006-07-07
    标题:Enantioselective synthesis of pyrrolidines substituted with flavones, and intermediates thereof
    发明人:SIVAKUMAR MEENAKSHI; SHUKLA MANOJ; JADHAV PRAMOD KUMAR; BORHADE AJIT
    权利人:PIRAMAL LIFE SCIENCES LTD
    摘要:The present invention relates to an enantioselective synthesis of (+)-trans enantiomer of pyrrolidines substituted with flavones, represented by Formula 1 or salts thereof, which are inhibitors of cyclin dependant kinases and can be used for treatment of proliferative disorders such as cancer n nwherein Ar has the meaning as indicated in the claims.

    专利号:US-10407401-B1
    优先权日:2018-08-04
    标题 :Process for synthesis of Oroxylin A
    发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA
    权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; RAMANUJAM RAJENDRAN; HEMANTHA HOSAHALLI PRABHAKARA; SAMI LABS LTD
    摘要:Disclosed is a novel, simple, scalable and environment friendly process for the synthesis of Oroxylin A from Baicalin. Baicalin is esterified to obtain a methyl ester which is further selectively methylated to provide Oroxylin A glucuronide methyl ester which on de-glycosylation results in the formation of Oroxylin A.

    专利号:WO-2024260915-A1
    优先权日:2023-06-19
    标题:Dynamic covalent chemistry of spiropyrans for synthesis of photoswitchable photoinitiators and uses thereof
    发明人:GARMSHAUSEN YVES
    权利人:XOLO GMBH
    摘要:The present invention relates to spiropyrans and process for the manufacture of them. In particular, a method is provided to exchange the indole and salicylaldehyde part of a spiropyran in a reversible reaction. The method is used for the synthesis of dual color photoinitiators with specific substituents and substitution patterns, which result in improved dual color volumetric printing (xolography). Furthermore, a process for locally polymerizing a starting material by dual color photopolymerization is disclosed.
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    合成参考文献


    参考文献:10.1515/znc-2009-11-1215
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    摘要:Bensasson RV, Zoete V, Jossang A, Bodo B, Arimondo PB, Land EJ. Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters. Free Radic Biol Med. 2011 Oct 01;51(7):1406–10. doi: 10.1016/j.freeradbiomed.2011.06.021.
    参考文献:10.1007/s10895-011-0919-y
    摘要:Shanker N, Dilek O, Mukherjee K, McGee DW, Bane SL. Aurones: Small Molecule Visible Range Fluorescent Probes Suitable for Biomacromolecules. Journal of Fluorescence. 2011 Jul 12;21(6):2173. doi: 10.1007/s10895-011-0919-y.
    参考文献:10.1080/10286020.2011.586340
    摘要:Wei H, Wu G, Lei Y, Xiong C, Ruan J. Neuropective constituents from the rhizomes ofAbacopteris penangiana. Journal of Asian Natural Products Research. 2011 Aug;13(8):707–13. doi: 10.1080/10286020.2011.586340.
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