CAS: 4761-93-7; Biguanidehydrochloride
该化合物是一种化学化合物,主要因其在制药和工业应用中作为前体或中间体的作用而得到承认,其结构具有与盐酸盐结合的重聚度,增强了溶性与稳定性,使之适合合成过程;该化合物因其在形成协调综合体方面的活性及其在抗微生物和抗糖尿病药物开发中的效用而受到重视;其盐化形式确保改进了处理和储存特性;Biguaide Hitrodrodroid由于反应的纯度和可靠性而经常用于研究环境;正确处理需要遵守关于血压和潜在刺激物质的标准安全议定书.
相似化合物
56-03-1 1674-62-0 21770-81-0物理性质
上下游产品
CAS号56-03-1 双胍合成工艺路线路线简述
📜盐酸胍置于potassium Tert-Butylate体系中,用 N-甲基吡咯烷酮 作为反应溶剂,化学反应生成 缩二胍盐酸盐
参考文献:柠檬酸gefapixant(mk-7264)的绿色可持续制造工艺开发,第3部分:二氨基嘧啶核的一锅式甲酰化-环化序列的开发
标题:柠檬酸gefapixant(mk-7264)的绿色可持续制造工艺开发,第3部分:二氨基嘧啶核的一锅式甲酰化-环化序列的开发
摘要:描述了开发安全,可靠和高效的生产路线的方法,以合成柠檬酸吉法pixant(mk-7264)的关键中间体二氨基嘧啶1.通过进行同位素标记实验和鉴定杂质,建立了在胍存在下环化步骤的完整机理的认识.在机械理解的指导下,还将提出通过使用添加剂减少三嗪(9)形成和胍负载量来修饰环化反应的进一步尝试.这种新开发的方法可提供化合物1 以商业规模获得88-94%的收率,并解决了早期合成路线的缺点,包括高pmi,低原子经济性,长循环时间和多次纯化以达到所需质量.
DOI:10.1021/acs.Oprd.0C00246
海关参考信息
- 2921199090-其他无环单胺
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专利信息
专利号:US-11744248-B2
优先权日:2017-08-20
标 题:Disinfectant composition for control of clostridium difficile spore
发明人：SMYTH BRUCE; BRALKOWSKI MICHAEL
权利人:SMYTH BRUCE; BRALKOWSKI MICHAEL; ENVIRO SPECIALTY CHEMICALS INC
摘要:A composition and method for inducing and inflicting damage to cell membranes of microorganism by inducing changes in membrane permeability caused by polycation-induced membrane pores. The control of Clostridium difficile spores with an efficacy of 99.99% on hard surfaces is provided. The invention includes the application of an evaporation-induced self-assembly, surfactant-mediated synthesis or self-condensing polymer, which forms a film which is both flexible on the surface as a nano-polymeric coating and with refractive index yielding a transparent coating. The polymeric matrix includes various biocidal polymeric cationic quaternary salts, one being a silyl quaternary having a kinetic zeta potential to disrupt bacterial spores functions. The polymeric matrix consist of multiple small molecule biocides as well as polymerics biocide combinations not otherwise seen to develop an surface topography of peaks and troughs in the nano range to resist bacterial adhesion factors and subsequent biofilm formation. The surfactants induce self-assembly film topography.
专利号:CN-101638445-A
优先权日:2009-09-04
标题:Microwave Synthesis of Chitosan Biguanide Hydrochloride
专利号:CN-118852034-A
优先权日:2024-07-22
标题 :Green synthesis method of 3, 5-diamino-1, 2, 4-triazole
专利号:CN-104404774-B
优先权日:2014-12-16
标 题 :Synthesis and application process of a microcapsule multifunctional finishing agent based on layer-by-layer electrostatic self-assembly
专利号:CN-118324702-A
优先权日:2024-04-16
标 题 :A novel synthesis method of 3,5-diamino-1,2,4-triazole
专利号:CN-106380598-B
优先权日:2016-10-15
标 题 :A kind of synthesis method and application of polymer ionic liquid
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合成参考文献
摘要:Pharmacological Research Communications., 6(117), 1974 []
摘要:Cesko-Slovenska Farmacie., 1(434), 1952 []
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