专利号:US-4567260-A 优先权日:1982-07-01 标题:Synthesis of 5-deazariboflavine 发明人:YONEDA FUMIO 权利人:TOYO JOZO KK 摘要:A new synthesis of 5-deazariboflavine is afforded by condensing N-D-ribityl-3,4-xylidine with a novel chemical intermediate, 6-chloro-5-formyluracil.
专利号:WO-2015092739-A1 优先权日:2013-12-19 标题:Process for preparation of alogliptin 发明人:VADALI LAKSHMANA RAO; DASARI SRINIVASA RAO; MANUKONDA SESHADRI RAO; PONDURI RAJASEKHAR 权利人:MYLAN LAB LTD 摘要:Processes for the preparation of alogliptin benzoate are disclosed. The present disclosure also provides intermediates useful in the synthesis of alogliptin benzoate.
专利号:US-4252946-A 优先权日:1971-10-12 标 题 :Pyrido-[2,3-d]pyrimidine compounds 发明人:WOOD HAMISH C S; PATERSON THOMAS 权利人:BURROUGHS WELLCOME CO 摘要:8-Substituted pyrido[2,3-d]pyrimidines having activity against microorganisms which utilize de novo synthesis of riboflavin.
专利号:US-6180791-B1 优先权日:1989-03-23 标 题 :Synthesis of 8-substituted xanthines
专利号:US-4113859-A 优先权日:1972-10-12 标 题:Certain pyrido-pyrimidines for treating mammalian and avian infections 发明人:WOOD HAMISH CHRISTOPHER SWAN; PATERSON THOMAS 权利人:BURROUGHS WELLCOME CO 摘要:8-Substituted pyrido [2,3-d]pyrimidines having activity against microorganisms which utilize de novo synthesis of riboflavin.
专利号:US-8623880-B2 优先权日:2009-03-23 标 题 :Fused pyrimidine-dione derivatives as TRPA1 modulators 发明人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL 权利人:CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; DESHMUKH VISHAL GOVINDRAO; DHONE SACHIN VASANTRAO; CHIKHALE RAJENDRA PRAKASH; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL; GLENMARK PHARMACEUTICALS SA 摘要:The invention described herein relates to novel fused pyrimidinediones derivatives of formula (I) which are TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). This invention also provides processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1.
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合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 396. 摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 335. 参考文献:10.1016/j.saa.2014.04.009 摘要:Ortiz S, Alvarez-Ros MC, Alcolea Palafox M, Rastogi VK, Balachandran V, Rathor SK. FT-IR and FT-Raman spectra of 6-chlorouracil: Molecular structure, tautomerism and solid state simulation. A comparison between 5-chlorouracil and 6-chlorouracil. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2014 Sep;130():653–68. doi: 10.1016/j.saa.2014.04.009. 参考文献:10.1021/jo0609881 摘要:Ulanenko K, Falb E, Gottlieb HE, Herzig Y. Novel 5-dimethylamino-1- and 2-indanyl uracil derivatives. J Org Chem. 2006 Sep 01;71(18):7053–6. doi: 10.1021/jo0609881.