CAS: 2724-69-8; 1-Methyl-3-Phenylthiourea
该化合物是具有硫尿素结构特征的有机化合物,其特征为甲基组和附于氮原子的苯基组,该化合物一般是白色至白晶状固体,因其在各种化学反应中的作用而闻名,特别是在合成其他有机化合物和作为分析化学的试剂方面的作用而闻名.N-Me乙-N欧元苯基尿拉由于其形成氢结壳的能力而在水和酒精等极地溶剂中表现出中等溶解性.该化合物对生物和药用化学感兴趣,因为它可能表现出生物活动,包括潜在的抗菌性.然而,与许多硫素衍生物一样,由于潜在的毒性和环境考虑,应当谨慎地处理该物质.建议在实验室中与该物质合作时采取适当的安全措施,包括使用个人防护设备.
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;;;; - InChIKey: IGEQFPWPMCIYDF-UHFFFAOYSA-N
- InChI=1S/C8H10N2S/c1-9-8(11)10-7-5-3-2-4-6-7/h2-6H,1H3,(H2,9,10,11)
- 计算化学: 氢键受体数1.0氢键供体数2可旋转键数1
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[ECHA物质上下游产品
methylamine hydr°Chloride phenyl isothi°Cyanate methyl thiois°Cyanate aniline methyl-(3-phenyl-thiazolidin-2-ylidene)-amine H-thiazol-2-ylidene)-phenyl-amine(3,4-dimethyl-3H-thiazol-2-ylidene)-phenyl-amine N,N-diphenylthiourea methylamine合成工艺路线路线简述
- 合成目标产物 1-Methyl-3-Phenyl-2-Thiourea 主要起始原料 Methylamine Hydrochloride And Phenyl Isothiocyanate
- (文献来源)合成步骤主要原料 Methylamine Hydrochloride 和 Phenyl Isothiocyanate
📜1,4-Dihydro-1-Methyl-4-Phenyl-5H-Tetrazol-5-On置于tetraphosphorus Decasulfide,1,4-环己二烯体系中,用 甲苯,乙腈 用作溶剂,化学反应 1.0H,反应生成1-甲基-3-苯基硫脲
参考文献:Clean Photodecomposition Of 1-Methyl-4-Phenyl-1H-Tetrazole-5(4H)-Thiones To Carbodiimides Proceeds Via A Biradical
标题:Clean Photodecomposition Of 1-Methyl-4-Phenyl-1H-Tetrazole-5(4H)-Thiones To Carbodiimides Proceeds Via A Biradical
摘要:The Photochemistry Of 1-Methyl-4-Phenyl-1H-Tetrazole-5(4H)-Thione (La) And 1-(3-Methoxyphenyl)4-Methyl-1H-Tetrazole-5(4H)-Thione (1B) Was Studied In Acetonitrile At 254 And 300 Nm,Which Involves Expulsion Of Dinitrogen And Sulfur To Form The Respective Carbodiimides 5A,B As Sole Photoproducts. Photolysis Of The Title Compounds In The Presence Of 1,4-Cyclohexadiene Trap Led To The Formation Of Respective Thioureas,Providing Strong Evidence For The Intermediacy Of A 1,3-Biradical Formed By The Loss Of Dinitrogen. In Contrast,A Trapping Experiment With Cyclohexene Provided No Evidence To Support An Alternative Pathway Of Photodecomposition Involving Initial Desulfurization Followed By Loss Of Dinitrogen Via The Intermediacy Of A Carbene. Triplet Sensitization And Triplet Quenching Studies Argue Against The Involvement Of A Triplet Excited State. While The Quantum Yields For The Formation Of The Carbodiimides 5A,B Were Modest And Showed Little Change On Going From A C6H5 (1A) To Momec(6)H(4) (1B) Substituent On The Tetrazolethione Ring,The Highly Clean Photodecomposition Of These Compounds To A Photostable End Product Makes Them Promising Lead Structures For Industrial,Agricultural,And Medicinal Applications.
Doi:10.1021/jo1019859
专利信息
专利号:US-11905244-B2
优先权日:2017-09-26
标题 :Chemical modulators of store-operated calcium channels and their therapeutic applications
发明人：ZHOU YUBIN; HE LIAN
权利人:TEXAS A & M UNIV SYS
摘要:Methods of identification of inhibitors of calcium release-activated calcium (CRAC) channel and small molecule inhibitors of CRAC channel, including methods of their synthesis and pharmaceutical use, are disclosed.
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📌 第三方产品分析报告
合成参考文献
参考文献:10.1107/s1600536814007442
摘要:Su HX. 1-Methyl-3-phenyl-thio-urea. Acta Crystallogr Sect E Struct Rep Online. 2014 May 01;70(Pt 5):o528.
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