CAS: 26189-59-3; 1-Chloro-N,N,2-Trimethylprop-1-En-1-Amine

上下游产品

N,N,2-trimethylpropionamide 1,1-bis(dimethylamino)-2,2-dimethylethylene 1-chlor-N,N,2-trimethylpropaniminium-chlorid 1-bromo-N,N,2-trimethyl-1-propen-1-amine 1-(4-(dimethylamino)phenyl)-2-methylpropan-1-one N,N,2-trimethylpropionamide 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride

Nn-Dimethylchloroisobutyriminium Chloride置于三甲胺体系中,用 正戊烷 用作溶剂,以0.465 G的收率获得1-氯-N,N,2-三甲基丙烯胺
参考文献:通过[2 + 2]环切法实际合成3-酰基环丁酮.锌(II)催化电子缺陷型烯烃与α-氯烯胺缩合的机理和实用性
标题:通过[2 + 2]环切法实际合成3-酰基环丁酮.锌(II)催化电子缺陷型烯烃与α-氯烯胺缩合的机理和实用性
摘要:将简单的叔酰胺转化为α-氯亚胺的新条件,以及它们在zn(II)催化的与商业α,β-不饱和羰基化合物进行的环加成反应中的使用,可以快速,区域控制地获得3-酰基环丁酮.反应在无溶剂的环境温度下进行,得到带有全碳取代的季碳原子的应变[2 + 2]加合物.假定的酮亚胺中间体的重算从头计算以及苯乙烯基烯烃的研究表明,Zn(otf)2在催化过程中具有双重作用.
Doi:10.1021/jo102257K

专利信息

专利号:US-2017327504-A1
优先权日:2014-10-30
标 题:Synthesis of Substituted 1H-Pyrazolo[3,4-D]Pyrimidines
发明人：ROSE CHRISTOPHER; SILBERGER HERBERT; SCHREINER ERWIN; FELZMANN WOLFGANG; MARAS NENAD
权利人:SANDOZ AG
摘要:The present invention refers to the synthesis and intermediates of substituted bicyclic compounds by using a central 1H-pyrazolo[3,4-d]pyrimidine of formula (I), which is assembled starting from 4,6-dichloropyrimidine carboxylic acid. The invention in particular refers to the synthesis of the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one(ibrutinib) and its synthesis intermediates.

专利号:US-7973175-B2
优先权日:2005-09-28
标 题 :Synthesis of renin inhibitors involving a cycloaddition reaction
发明人：MICKEL STUART J; MARTERER WOLFGANG
权利人:NOVARTIS AG
摘要:The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula III, n nwherein R, R 1 , and R′ are as defined in the specification, or a salt thereof, and a compound of formula IVn n nwherein R, R 1 , R 2 and R′ are as defined in the specification, and processes of manufacturing these.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-2024208926-A1
优先权日:2021-03-24
标题:New process for the synthesis of 5-{5-chloro-2-[(3s)-3-[(morpholin-4-yl)methyl]-3,4-dihydroisoquinoline-2(1h)- carbonyl]phenyl}-1,2-dimethyl-1h-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds
发明人：PIN FRÉDÉRIC; PETHÖ BÃ?LINT
权利人:SERVIER LAB; NOVARTIS AG
摘要:The present invention relates to a new process for preparing 5-{5-chloro-2-[(38)-3-[(morpholin-4-yl)methyl]-3.4-dihydr oisoquinoline-2(1H)-carbonyl]phenyl}-1,2-dimethyl-1/H-pyrrole-3-carboxylic acid derivatives and its application for the production of pharmaceutical compounds.

专利号:US-5218097-A
优先权日:1988-12-07
标题:Process for the preparation of protected mono-sugar and oligo-sugar halides
发明人：ERNST BEAT
权利人:CIBA GEIGY CORP
摘要:The reaction of protected monosaccharides or oligosaccharides or protected monosaccharide and oligosaccharide derivatives containing an anomeric hydroxyl group with secondary α-haloenamines affords high yields of protected glycosyl halides, which are valuable intermediates for the introduction of sugar groups in the synthesis of oligosaccharides, glycolipids or glycopeptides.

专利号:US-9035070-B2
优先权日:2010-07-30
标 题 :Process for the preparation of 1-aryl-pyrazol-3-one intermediates useful in the synthesis of sigma receptors inhibitors
发明人：BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER
权利人:BARTRA SANMARTI MARTÃ?; BERENGUER MAIMO RAMON; MEDRANO RUPEREZ JORGE; GARCIA GOMEZ JORGE; ARIZA PIQUER JAVIER; ESTEVE QUÃ?MICA S A
摘要:The invention relates to a process for preparing 1-aryl-pyrazol-3-one intermediates, tautomers, and salts thereof, to novel intermediates, and to the use of the intermediates in the preparation of sigma receptor inhibitors.