专利号:US-8431523-B2 优先权日:2006-06-01 标题:Oligomeric biosurfactants in dermatocosmetic compositions 发明人:OWEN DONALD R; FAN LILI 权利人:OWEN DONALD R; FAN LILI 摘要:Oligomeric acylated biosurfactants (“OABsâ€?) having low critical micelle concentrations of from about 1.0 ppm to about 200 ppm, preferably less than about 50 ppm, in an aqueous solution of Minimal Essential Media that can lower the surface tension in the aqueous MEM environment to less than about 50 dynes/cm 2 and have the ability to increase metabolic soluble proteins and/or increase synthesis of extracellular skin matrix proteins and/or increase rates of cell turnover while at the same time exhibiting comparatively low toxicity—preferably, an LD 50 of greater 200 ppm in 37 year-old female fibroblast cells. Another aspect of the present invention is directed to the use of OABs in formulations that are topically-applied, by which is meant the formulation is placed in direct contact with the skin, hair and nails as well as mucosa of the eyes, ears, nose, mouth, anus and vagina.
专利号:ES-2403154-T3 优先权日:1997-04-11 标 题 :Methods and compositions for the synthesis of long chain polyunsaturated fatty acids in plants
专利号:US-9751911-B2 优先权日:2012-11-27 标 题:Solomonamide analogue compounds, pharmaceuticals containing solomonamide analogue compounds, and processes for the preparation thereof 发明人:REDDY DUMBALA SRINIVASA; KOMIRISHETTY KASHINATH; NATARAJAN VASUDEVAN 权利人:COUNCIL SCIENT IND RES 摘要:Solomanamide analogs of Formula-I having anti-inflammatory activity, and viable synthetic routes for the preparation of such analogs, including the synthesis of macrocyclic core of Salomanamide analogs. The Solomanamide analogs of Formula-I or their pharmaceutical salt may be provided in a pharmaceutical composition and administered in an effective amount for the treatment of inflammation and/or pain.
专利号:CA-2394414-A1 优先权日:1999-12-16 标 题 :Moss genes from physcomitrella patens encoding proteins involved in the synthesis of tocopherols carotenoids
专利号:WO-9846763-A1 优先权日:1997-04-11 标题:Methods and compositions for synthesis of long chain polyunsaturated fatty acids
专利号:US-5780025-A 优先权日:1986-12-24 标题:Compositions and methods for the synthesis and assay of enkephalinase 发明人:MALFROY-CAMINE BERNARD; SCHOFIELD PETER R 权利人:GENENTECH INC 摘要:DNA isolates coding for enkephalinase and methods of obtaining such DNA are provided, together with expression systems for recombinant production of enkephalinase for use in therapeutic or diagnostic compositions. Enkephalinase assays are facilitated by novel enkephalinase substrates.
参考文献:10.1021/jm0511029 摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029. 参考文献:10.1038/nchembio.2285 摘要:Elshahawi SI, Cao H, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN, Thorson JS, Singh S. Structure and specificity of a permissive bacterial C-prenyltransferase. Nature Chemical Biology. 2017 Feb 06;13(4):366–8. doi: 10.1038/nchembio.2285.