CAS: 2357-47-3; 4-Fluoro-3-(Trifluoromethyl)Aniline

上下游产品

CAS号400-74-8 2-氟-5-硝基三氟甲苯 | CAS号98-46-4 间硝基三氟甲苯 | CAS号105224-02-0 [4-Fluoro-3-(tr... | CAS号393-37-3 5-溴-2-氟三氟甲苯 | CAS号143151-01-3 N-(4-FLUORO-2-N... | CAS号1799-83-3 ethyl N-[4-fluo... | CAS号1998-81-8 propan-2-yl N-[... | CAS号2145-38-2 N-(4-FLUORO-3-(... | CAS号61721-07-1 4-氟-3-三氟甲基苯酚 | CAS号67515-59-7 4-氟-3-三氟甲基苯甲腈 | CAS号502496-22-2 (4-氟-3-(三氟甲基)苯基... | CAS号868692-49-3 4-氟-2-碘-5-(三氟甲基)苯胺

2-氟-5-硝基三氟甲苯置于palladium On Activated Charcoal 氢气体系中,用 溶剂黄146 用作溶剂,化学反应生成4-氟-3-三氟甲基苯胺
参考文献:新型的带取代苯基的7-咪唑基-6-三氟甲基喹喔啉羧酸的合成及ampa受体拮抗活性,并通过引入cf3基团改善了其非常好的理化性能.
标题:新型的带取代苯基的7-咪唑基-6-三氟甲基喹喔啉羧酸的合成及ampa受体拮抗活性,并通过引入cf3基团改善了其非常好的理化性能.
摘要:我们描述了一系列新的7-咪唑基-6-三氟甲基喹喔啉羧酸的合成,物理化学和生物学特性,这些取代羧酸具有通过c-7位置的氨基甲酸酯键连接的取代苯基.我们发现在c-6位引入三氟甲基带来了非常好的生物活性和理化性质.其中,具有4-羧基苯基的化合物9K(krp-199)在体外具有对ampa-R的高效力和选择性,并且在体内具有非常好的神经保护作用.此外,该化合物表现出非常好的理化性质,例如对光的稳定性和在水溶液中的非常好溶解性.
Doi:10.1016/j.Bmcl.2004.07.093

专利信息

专利号:WO-2011114184-A1
优先权日:2010-03-15
标题 :Amides of heterocyclic compounds as trpa1 inhibitors
发明人：CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
权利人:GLENMARK PHARMACEUTICALS SA; CHAUDHARI SACHIN SUNDARLAL; KUMAR SUKEERTHI; THOMAS ABRAHAM; PATIL NISHA PARAG; KADAM ASHOK BHAUSAHEB; WAGHMARE NAYAN TATERAO; KHAIRATKAR-JOSHI NEELIMA; MUKHOPADHYAY INDRANIL
摘要:Amides of heterocyclic compounds as Transient Receptor Potential subfamily A (TRPA) modulators are provided In particular, compounds described herein are useful for treating or preventing diseases, conditions and/ or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. (I).

专利号:US-2005026965-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2003004189-A1
优先权日:2000-12-29
标 题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides

专利号:US-2010063105-A1
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-n-oxides

专利号:US-7141590-B2
优先权日:2000-12-29
标题 :Pharmaceutical uses and synthesis of nicotinanilide-N-oxides
发明人：CUTSHALL NEIL S; YAGER KRAIG M
权利人:UCB SA
摘要:Disclosed are nicotinanilide-N-oxide compounds, methods for their production, pharmaceutical compositions which include these compounds, and methods for their use in various therapies.

专利号:CA-2693182-A1
优先权日:2007-06-29
标 题:Pyrimidine compounds, methods of synthesis thereof, and use thereof in the treatment of raf kinase-mediated disorders