专利号:EP-1578714-B1 优先权日:2002-12-20 标题:Novel chiral compounds derived from hexanoic acid esters, method and intermediate chemicals for the preparation and use thereof for synthesis of 2-(bromomethyl)2-ethyl hexanoic chiral acid 发明人:CROCQ-STUERGA VERONIQUE; ROUSSEL PATRICK 权利人:AVENTIS PHARMA SA 摘要:The invention relates to a chiral compound of a formula (I), wherein R1 is hydroxyl or a carboxy activator group and R2 is alkyl eventually substituted by halogen or benzyl. The preparation and the use of the inventive compound for synthesis of 2-bromomethyl-2-ethyl hexanoic chiral acid and the novel intermediate chemicals are also disclosed.
专利号:WO-9214492-A1 优先权日:1991-02-14 标 题:In situ synthesis of radiopharmaceuticals 发明人:VERBRUGGEN ALFONS M 权利人:MALLINCKRODT MEDICAL INC 摘要:The present invention relates to a process of making radiopharmaceuticals in situ, i.e. wherein a radionuclide and an acyclic ligand react with constituents of the complex forming reaction solution to produce an administratable radiopharmaceutical agent. By forming radiopharmarceuticals according to the present invention, it is possible to obtain radiopharmaceuticals previously unattainable because of problems associated with the ligand synthesis or with the complex forming reaction.
专利号:US-5350681-A 优先权日:1986-08-18 标题 :Enzymatic membrane method for the synthesis and separation of peptides 发明人:IACOBUCCI GUILLERMO A; BROSE DANIEL J; RAY RODERICK J; VAN EIKEREN PAUL 权利人:COCA COLA CO 摘要:The present invention discloses a method for the enzymatic synthesis of a peptide. A protected peptide having a C-terminal carboxylate group or a protected, N-acyl amino acid having an alpha carboxylate group is reacted with a protected peptide having an N-terminal ammonium group or a protected amino acid having an alpha ammonium group in the presence of a condensation enzyme under conditions in which the carboxylate group and the ammonium group condense to form a protected, uncharged, peptide product. This peptide product is transported across a water-immiscible hydrophobic phase into an aqueous product phase and prevented from back diffusing across the water-immiscible hydrophobic phase. The peptide product can be converted, chemically or enzymatically, to a charged species that cannot back diffuse across the water-immiscible phase into the aqueous reaction phase. The water-immiscible hydrophobic phase is an ion rejection membrane separating the aqueous reaction phase from the product phase creating oil/water interfaces with each of the aqueous phases.
专利号:US-9951149-B2 优先权日:2013-06-17 标 题 :Reversible heparin molecules and methods of making and using the same 发明人:LIU JIAN; XU YONGMEI; LINHARDT ROBERT J; HARRIS EDWARD 权利人:UNIV NORTH CAROLINA CHAPEL HILL; RENSSELAER POLYTECH INST; NUTECH VENTURES; RENSSELAER POLYECHNIC INST 摘要:Methods and systems for synthesizing heparin compounds are provided. The chemoenzymatic synthesis of structurally homogeneous low molecular weight heparins that have a reversible anticoagulant activity is provided. Also disclosed are heparin compounds having anticoagulant activity, including a binding affinity to antithrombin and an anti-Xa activity, but no detectable anti-lla activity. Additionally, provided are synthetic, low-molecular weight heparin compounds with reversible anticoagulant activity, where the anticoagulant activity is reversible by protamine.
专利号:WO-2025056767-A1 优先权日:2023-09-15 标题 :Process for the preparation of enantiomerically enriched aliphatic amines 发明人:BOU HAMDAN FARHAN; GODINEAU EDOUARD; SMEJKAL TOMAS; DUMEUNIER RAPHAEL; BOUSSEMGHOUNE MOHAMED ABDELOUAHAB; BLUM MATHIAS 权利人:SYNGENTA CROP PROTECTION AG 摘要:The present invention relates to a process for the preparation of enantiomerically enriched cyclobutylamines of formula (I) from α-tertiary cyclobutanones and reacting said enantiomerically enriched cyclobutylamines to enantiomerically enriched cyclobutylamides. Such compounds are useful intermediates in the synthesis of microbiocidal thiazole compounds.
专利号:US-4246373-A 优先权日:1980-02-14 标 题 :Synthesis of substituted cyclopentadienes and cyclopentadiene-functionalized polymers 发明人:KENNEDY JOSEPH P; CASTNER KENNETH F 权利人:KENNEDY JOSEPH P; CASTNER KENNETH F 摘要:Aluminum cyclopentadienyl compounds can be used to synthesize a variety of organic molecules containing the cyclopentadiene group, e.g., substituted cyclopentadiene compounds, polymer molecules with cyclopentadiene pendant groups, and polymer molecules with cyclopentadiene terminal groups.
1: Sharma VP, Kumar A, Kumar S, Barh A, Kamal S. Substrate sterilization with thiophanate-methyl and its biodegradation to carbendazim in oyster mushroom (Pleurotus ostreatus var. florida). Environ Sci Pollut Res Int. 2020 Jan;27(1):899-906. doi: 10.1007/s11356-019-07050-5. Epub 2019 Dec 9. 16(1):e05133. doi: 10.2903/j.efsa.2018.5133. 3: Hu J, Deng S, Gao T, Lamour K, Liu X, Ren H. Thiophanate-methyl resistance in Sclerotinia homoeocarpa from golf courses in China. Pestic Biochem Physiol. 2018 Nov;152:84-89. doi: 10.1016/j.pestbp.2018.09.004. Epub 2018 Sep 14. 103(1):89-94. doi: 10.1094/PDIS-05-18-0872-RE. Epub 2018 Nov 6. 98(5):720-725. doi: 10.1007/s00128-017-2066-x. Epub 2017 Mar 23. 248:125941. doi: 10.1016/j.chemosphere.2020.125941. Epub 2020 Jan 21.
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