氯甲酸苄酯置于三乙胺,三氟乙酸体系中,化学反应 2.67H,反应生成N-Cbz-Beta-丙氨酸 参考文献:The Use Of Cellulose (Chromatography Paper) As A Cheap,Versatile And Non-Covalent Support For Organic Molecules During Multi-Step Synthesis 标题:The Use Of Cellulose (Chromatography Paper) As A Cheap,Versatile And Non-Covalent Support For Organic Molecules During Multi-Step Synthesis 摘要:纤维素色谱纸提供了一种新颖的非共价支持,用于多维阵列的合成和原位纯化. Doi:10.1039/b208083D
专利号:US-7351852-B2 优先权日:2000-09-05 标题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates therof, and processes for productions of them 发明人:IKEDA HISAFUMI; SAITO ISAO; NAKAMURA YUSHIN 权利人:CREDIA JAPAN CO LTD 摘要:A process for amino acid derivatives shown by the below general formula (I): n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms.) having an object to provide a process of the amino acid derivatives of the formula (I) and their synthetic intermediate, t-butoxycarbonylamino-ethylamine, whereby it requires no tedious procedure and is also good in yield, and its application to a mass production is easy, and to provide novel amino acid derivatives of the formula (IV), their synthetic intermediates, and a process thereof, characterized in that it comprises a step to obtain the amino acid derivatives shown by the general formula (I) by hydrolysis of compounds shown by the below formula (II):n n n(wherein R 1 has the same meaning as described above, and R 2 means a straight chain or branched chain alkyl group with 1-4 carbon atoms.) as well as amino acid derivatives shown by the general formula (IV):n n n(wherein R 1 means a hydrogen atom or a straight chain or branched chain alkyl group with 1-5 carbon atoms, and n means any one of integers 1-11.), and a process for the amino acid derivative, characterized in that it comprises a reduction step of benzyloxycarbonyl-ω-amino acid derivatives.
专利号:US-7417035-B2 优先权日:1998-11-19 标 题:Phospholipid derivatives of non-steroidal anti-inflammatory drugs 发明人:KOZAK ALEXANDER; SHAPIRO ISRAEL 权利人:DPHARM LTD 摘要:Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions.
专利号:US-6498150-B2 优先权日:1995-10-17 标 题 :Low molecular weight cell, bone marrow and immune stimulants 发明人:TAUB FLOYD; PERUN THOMAS J; MURRAY CHRISTOPHER K; DAUGHENBAUGH RANDALL J; LEDNICER DANIEL 权利人:DOVETAIL TECHNOLOGIES INC 摘要:The present invention relates to peptide-like compounds, eg aminocarboxylic acid amide derivatives, and to methods of using same to stimulate cells of the immune system, bone marrow and other organs. The present compounds can be used to enhance vaccination, increase synthesis of and enhance function of blood cell components and enhance anti-neoplastic effects of various agents. The compounds of the invention can be used to produce a variety of further pharmacologic effects.
专利号:US-2008167491-A1 优先权日:2000-05-09 标题:T-butoxycarbonylaminoethylamine for the Synthesis of PNA Monomer Units, Amino Acid Derivatives, Intermediates Thereof, and Processes for Productions of Them
专利号:US-2005187402-A1 优先权日:2000-09-05 标 题 :T-butoxycarbonylaminoethylamine for the synthesis of PNA monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
专利号:EP-1318142-B1 优先权日:2000-09-05 标题:T-butoxycarbonylaminoethylamine for the synthesis of pna monomer units, amino acid derivatives, intermediates thereof, and processes for productions of them
[参考文献]: Luckose F, Et Al. Effects Of Amino Acid Derivatives On Physical, Mental, And Physiological Activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1109. [参考文献]: Chu-Biao Xue, Et Al. Asymmetric Synthesis Of Trans-2,3-Piperidinedicarboxylic Acid And Trans-3,4-Piperidinedicarboxylic Acid Derivatives. J Org Chem. 2002 Feb 8;67(3):865-70. [参考文献]: Jiansheng Liu, Et Al. Functionalized Nanocarrier Combined Seizure-Specific Vector With P-Glycoprotein Modulation Property For Antiepileptic Drug Delivery. Biomaterials. 2016 Jan:74:64-76.
合成参考文献
摘要:Lloyd, C. M.; Dowell, K. F.; Brittain, W. D. G., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2025) 2. 参考文献:10.1007/s00726-012-1443-3 摘要:Cal M, Jaremko M, Jaremko Ł, Stefanowicz P. One-pot efficient synthesis of N(α)-urethane-protected β- and γ-amino acids. Amino Acids. 2013 Mar;44(3):1085–91. 参考文献:10.1007/s00213-018-4917-5 摘要:Jeanblanc J, Bourguet E, Sketriené D, Gonzalez C, Moroy G, Legastelois R, Létévé M, Trussardi-Régnier A, Naassila M. Interest of new alkylsulfonylhydrazide-type compound in the treatment of alcohol use disorders. Psychopharmacology (Berl). 2018 Jun;235(6):1835–44. doi: 10.1007/s00213-018-4917-5.