CAS: 22990-19-8; 1-Phenyl-1,2,3,4-Tetrahydroisoquinoline

相似化合物

118864-75-8 180272-45-1 5464-92-6

上下游产品

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Tert-Butyl 1-Phenyl-3,4-Dihydroisoquinoline-2(1H)-Carboxylate置于盐酸体系中,用 水,乙酸乙酯 用作溶剂,化学反应 6.0H,以95%的收率获得1-苯基-1,2,3,4-四氢异喹啉
参考文献:钯催化的c(sp3)n-Boc苄基烷基胺通过去质子交叉偶联过程的h酰化
标题:钯催化的c(sp3)n-Boc苄基烷基胺通过去质子交叉偶联过程的h酰化
摘要:二芳基甲胺是制药工业中的关键中间体和产品.本文中,我们公开了一种通过ch官能化合成这些重要化合物的新颖方法.呈现是可逆的脱质子化ñ-Boc Benzylalkylamines在苄基ç H带原位由基于nixantphos-钯催化剂的芳基化(产率50-93%,29个实施例).该方法在n-Boc-四氢异喹啉中也很成功.该方法的优点是避免了强碱,低温以及需要将金属互化物成主族金属以进行偶联的问题.
Doi:10.1002/chem.201502017

专利信息

专利号:US-7741489-B2
优先权日:2007-03-30
标题:Process for the synthesis of solifenacin
发明人：PUIG SERRANO JORDI; CAMPS PELAYO
权利人:MEDICHEM SA
摘要:The present invention provides an improved synthetic strategy for the preparation of solifenacin and pharmaceutically acceptable salts thereof.

专利号:US-2011077405-A1
优先权日:2008-05-23
标题:Process for preparation of enantiomerically pure (s)-1-phenyi-1,2,3,4- tetrahydroisoquinoline
发明人：ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
权利人:ZEGROCKA-STENDEL OLIWIA; ZAGRODZKA JOANNA; LASZCZ MARTA
摘要:Process for preparation of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline wherein 1-phenyl-1,2,3,4-tetrahydroisoquinoline is reacted with D-(−)-tartaric acid in a solvent system comprising of methanol and water, preferably at 3.3:1 to 1:1 volume ratio, the crystallization mixture is left for crystallization and (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline is released from obtained crystalline diastereoisomeric salt according to standard procedures. (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is the intermediate in enantiomeric synthesis of solifenacin.

专利号:US-2009326230-A1
优先权日:2006-07-19
标题 :Process for preparing solifenacin and its salts
发明人：MATHAD VIJAYAVITTHAL THIPPANNACHAR; LILAKAR JAYDEEPKUMAR DAHYABHAI; GILLA GOVERDHAN; KIKKURU SRIRAMIREDDY; CHINTA RAVEENDRA REDDY; DUDIPALA SWAROOPA
权利人:REDDYS LAB LTD DR; REDDYS LAB INC DR
摘要:The present invention relates to solifenacin in solid form and a process for its preparation and to a process for the preparation of (1S)-1-Phenyl-1,2,3,4-tetrahydro-isoquinoline, a key intermediate in the synthesis of solifenacin and its salts.

专利号:US-2010029944-A1
优先权日:2006-11-22
标题:Process for the Synthesis of Solifenacin
发明人：PUIG JORDI; SANCHEZ LAURA; MASLLORENS ESTER; AUGER IGNASI; BOSCH JORDI
权利人:CORPORACION MEDICHEM S L
摘要:This invention provides improved methods for making solifenacin and pharmaceutically acceptable salts thereof. The instant methods are unexpectedly advantageous in their simplicity and efficiency.

专利号:WO-2008120080-A2
优先权日:2007-03-30
标 题:An improved process for the synthesis of solifenacin

专利号:US-2008242697-A1
优先权日:2007-03-30
标题 :Process for the synthesis of solifenacin