N-Boc-S-烯丙基-L-半胱氨酸甲酯置于三氟乙酸,Lithium Hydroxide体系中,用 二氯甲烷,四氢呋喃,水 用作溶剂,化学反应 3.0H,以57%的收率获得s-烯丙基-L-半胱氨酸 参考文献:Olefin Metathesis Reactions Of Amino Acids,Peptides And Proteins Containing Allyl Sulfide Groups 标题:Olefin Metathesis Reactions Of Amino Acids,Peptides And Proteins Containing Allyl Sulfide Groups 摘要:揭示了一种用于修饰氨基酸,蛋白质或肽的方法.该方法包括在促进烯烃交换反应的催化剂存在下,将含有碳-碳双键的化合物与含有烯丙基硫醚基团的氨基酸,蛋白质或肽反应,以形成修饰后的氨基酸,蛋白质或肽.首选的碳-碳双键含有化合物包括碳水化合物.
专利号:US-2018265547-A1 优先权日:2014-07-18 标 题 :Z-selective olefin metathesis of peptides 发明人:MANGOLD SHANE L; GRUBBS ROBERT H 权利人:CALIFORNIA INST OF TECHN 摘要:The invention relates generally to the synthesis of modified amino acids and modified peptides in the presence of cyclometalated catalysts. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.
专利号:WO-2024199465-A1 优先权日:2023-03-30 标 题:Unnatural amino acid in cellulo synthesis for site-specific protein modification 发明人:CHAN MICHAEL KENNETH; LEE MARIANNE; CHENG JIAHUI 权利人:UNIV HONG KONG CHINESE 摘要:Provided are genetically modified host cells containing engineered enzymes that support the synthesis of unnatural amino acids, such as D-Cys-ε-Lys, and the incorporation of such unnatural amino acids into a newly synthesized protein. These cells are therefore capable of in vivo or in cellulo synthesis of a protein containing one or more unnatural amino acids strategically placed at pre-determined locations for site-specific modification of the protein. Also provided are the corresponding methods for in vivo synthesis of modified proteins as well as the modified proteins produced by the method.
专利号:US-12036300-B2 优先权日:2021-03-31 标题:Methods and compositions for improving skin 发明人:LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN 权利人:OREAL 摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.
专利号:US-9707201-B2 优先权日:2013-07-15 标 题:Allium extracts 发明人:BENNETT NORMAN JOHN; RAMSEY EDWARD DALHOUSIE 权利人:LEPTREX LTD 摘要:Improvements in or relating to Allium extracts. In particular, improvements in or relating to extending the therapeutic half-life or duration of Allium extracts. The invention further relates to the synthesis of methyl methyl thiosulfinate in a mixture with varying molar or mass ratios depending on the reaction conditions, in particular from either methiin or alliin alone or a mixture of both. Methods of treatment methicillin-resistant Staphylococcus aureus are also provided. Also provided is a kit comprising methiin in a first container and alliin in a second container.
专利号:US-12378584-B2 优先权日:2018-06-13 标 题 :Methionine analogue synthesis 发明人:WILTSCHI BIRGIT; FLADISCHER PATRIK; OFFNER-MARKO LISA-RAMONA; HECKENBICHLER KATHRIN; BREINBAUER ROLF 权利人:ENGENES BIOTECH GMBH 摘要:The present invention relates to a method for preparing a methionine analogue, comprising contacting a host cell with L-homoserine and one or more nucleophiles and cultivating said host cell and said one or more nucleophiles of (a) in a fermentation broth to produce said methionine analogue, wherein said host cell encodes and stably expresses a L-homoserine-O-acetyl-transferase (HSAT) and an O-acetyl-L-homoserine sulfhydrylase (OAHS). The present invention also relates to host cells encoding and expressing such HSAT and OAHS, as well as uses thereof for producing a methionine analogue.
专利号:US-2008194666-A1 优先权日:2005-04-02 标题:Combination Treatment Methods 发明人:JABBOUR HENRY NICOLAS; MILLAR ROBERT PETER; NAOR ZVI 权利人:MEDICAL RES COUNCIL 摘要:A method of treating an individual with a condition which condition is one wherein the individual with the condition benefits from the administration of GnRH and/or a GnRH analogue, the method comprising administering to the individual GnRH and/or a GnRH analogue and an inhibitor of prostaglandin synthesis and/or a prostaglandin receptor antagonist. The methods of the invention also include combating a sex-hormone dependent disease in an individual, and regulating fertility in an individual.
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合成参考文献
参考文献:10.1007/s002040050322 摘要:de Rooij BM, Boogaard PJ, Rijksen DA, Commandeur JNM, Vermeulen NPE. Urinary excretion of N -acetyl- S -allyl- L -cysteine upon garlic consumption by human volunteers. Archives of Toxicology. 1996 Aug 01;70(10):635–9. doi: 10.1007/s002040050322. 参考文献:10.1079/bjn2001343 摘要:Verhagen H, Hageman GJ, Rauma AL, Versluis-de Haan G, van Herwijnen MH, de Groot J, Törrönen R, Mykkänen H. Biomonitoring the intake of garlic via urinary excretion of allyl mercapturic acid. Br J Nutr. 2001 Aug;86 Suppl 1():S111–4. doi: 10.1079/bjn2001343. 参考文献:10.1006/abbi.1999.1247 摘要:Ripp SL, Itagaki K, Philpot RM, Elfarra AA. Methionine S-Oxidation in Human and Rabbit Liver Microsomes: Evidence for a High-Affinity Methionine S-Oxidase Activity That Is Distinct from Flavin-Containing Monooxygenase 3. Archives of Biochemistry and Biophysics. 1999 Jul;367(2):322–32. doi: 10.1006/abbi.1999.1247. 参考文献:10.1207/s15327914nc402_13 摘要:Balasenthil S, Rajamani Ramachandran C, Nagini S. S-Allylcysteine, a Garlic Constituent, Inhibits 7,12-Dimethylbenz[a]Anthracene-Induced Hamster Buccal Pouch Carcinogenesis. Nutrition and Cancer. 2001 May;40(2):165–72. doi: 10.1207/s15327914nc402_13. 摘要:Velmurugan B, Santhiya ST, Nagini S. Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity. Pol J Pharmacol. 2004 Mar;56(2):241–5.