CAS: 20656-61-5; Methyl 2-Chloro-3-Oxopropanoate

上下游产品

Methyl formate methyl chloroacetate formic acid ethyl estermethyl thiazole-5-carboxylate methyl 2-aminothiazole-5-carboxylate O5-benzoyl-β-D-ribofuranosyl)-thiazole-5-carboxylic acid methyl ester2-(O5-benzoyl-β-D-ribofuranosyl)-thiazole-5-carboxylic acid methyl ester 2-(5-benzoyloxymethyl-furan-2-yl)-thiazole-5-carboxylic acid methyl ester

📜在 盐酸体系中,化学反应生成甲基丙二酰氯
参考文献:化学研究与青霉素超敏反应的潜在相关性.Dl-2-苯氧基甲基青霉烯酸和dl-2-(2,6-二甲氧基苯基)青霉烯酸的合成
标题:化学研究与青霉素超敏反应的潜在相关性.Dl-2-苯氧基甲基青霉烯酸和dl-2-(2,6-二甲氧基苯基)青霉烯酸的合成
摘要:Dl-2-苯氧基melhylpenicillenic酸(的晶体样品14)和dl-2-(2,6-二甲氧基苯基)penicillenic酸(21)已经由反应合成dl青霉胺与2-苯氧基甲基-4-(甲氧基亚甲基)恶唑-5-酮和2-(2,6-二二甲氧基苯基)-4-(乙氧基亚甲基)恶唑-5-酮.这些关键的恶唑-5-酮中间体是通过适当取代的戊二酸二烷基乙缩醛的壬二酸化反应合成的.研究了氯化汞(II)与d-苯氧基甲基青霉素的反应,发现不适用于d-14的合成.结晶dl的比较-和分别通过"恶唑酮"和"氯化汞(11)"方法制备的无定形d-2-(2,6-二甲氧基苯基)青霉烯酸(21)表明,其纯度明显提高.Dl-材料.
Doi:10.1002/jhet.5570100609

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-11027027-B2
优先权日:2015-01-30
标 题:Pyridazinoindole compounds and methods for PET imaging
发明人：MANNING H CHARLES; CHEUNG YIU-YIN; BUCK JASON R; LI JUN
权利人:UNIV VANDERBILT
摘要:Embodiments of the invention include a novel synthesis of the translocator protein (TSPO) ligands, and methods of imaging a molecular events. Also disclosed are compounds for treatment of diseases, including cancer.

专利号:US-6642264-B1
优先权日:1999-04-06
标 题 :Thiazolobenzoimidazole derivatives
发明人：HAYASHIBE SATOSHI; ITAHANA HIROTSUNE; OKADA MASAMICHI; KOHARA ATSUYUKI; MAENO KYOICHI; YAHIRO KIYOSHI; SHIMADA ITSURO; TANABE KAZUHITO; NEGORO KENJI; KAMIKUBO TAKASHI; SAKAMOTO SHUICHI
权利人:YAMANOUCHI PHARMA CO LTD
摘要:This invention relates to novel thiazolo[3,2-a]benzoimidazole derivatives represented by the following general formula (I). The compounds provided by the invention act specifically on metabotropic glutamate receptors and are used as medicaments. The invention also provides novel compounds useful as intermediates for the synthesis of the compounds of the invention.(Symbols in the formula represent the following meanings. R<1>: carbamoyl, carbonyl, oxy, amino, carbonylamino or the like which may be substituted; R<2>: hydrogen, lower alkyl or the like; and R<3>, R<4 >and R<5>: hydrogen, lower alkyl and the like which may be the same or different from one another.)

专利号:US-9359298-B2
优先权日:2011-12-23
标题:Cajanine structure analogous compound, preparation method and use
发明人：LI ZHUORONG; JI XINGYUE; Xue situ; ZHENG GUANGHUI; LI YUHUAN; TAO PEIZHEN; JIANG JIANDONG
权利人:INST MED BIOTECHNOLOGY CAMS
摘要:Provided are cajanine structure analogous compounds, synthesis method and pharmacological effects thereof, the compounds of the present invention having the structure as represented by general formulas I, II, III, IV and V. Also provided are pharmaceutical compositions containing the compounds as active ingredient, and uses thereof; the compounds of the present invention having the pharmacological activities such as anti-virus, anti-virus-infection, nerve protection, anti-metabolic-diseases and the like. Also provided is a chemical total synthesis preparation method of the natural products cajanine, cajanine A and cajanine C. The present invention lays a foundation for the in-depth study and development of the compounds as clinical drugs in the future.