专利号:US-9783496-B2 优先权日:2013-04-02 标 题 :Oxindole compounds, solvent-free synthesis and use thereof 发明人:BIJU AKKATTU THANKAPPAN; KAICHARLA TRINADH; YETRA SANTHIVARDHANA REDDY; ROY TONY 权利人:COUNCIL SCIENT IND RES 摘要:The present invention discloses oxindole compounds and a single step, one pot reaction for the synthesis of oxindole derivates via a solvent free Passerini reaction of isocyanides, isatins and carboxylic acids.
专利号:US-6753449-B2 优先权日:2001-10-09 标题 :Cleavable linker for solid phase synthesis 发明人:GUO MAOJUN 权利人:ARQULE INC 摘要:Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.
专利号:US-2011263540-A1 优先权日:2008-07-25 标题 :Small-molecule inhibitors of protein synthesis inactivating toxins 发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B 摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.
专利号:US-11440892-B2 优先权日:2019-07-03 标 题 :Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis 发明人:SCHEIDT KARL A; LEE ANSOO 权利人:UNIV NORTHWESTERN 摘要:Disclosed are dihydrobenzoxazinone compounds, dihydroquinolone compounds, and methods of their synthesis. The disclosed compounds may be prepared by reacting a benzoxazinedione compound and a ketone compound in the presence of an N-heterocyclic carbine (NHC) catalyst to perform a NHC-catalyzed decarboxylative cycloaddition. The disclosed compounds may be utilized to treat diseases and disorders associated with the biological activity of dihydrobenzoxazinone compounds and dihydroquinolone compounds.
专利号:US-2025236590-A1 优先权日:2021-10-20 标题 :A method for the preparation of indole-3-carboxylic acid derivatives 发明人:DEB INDUBHUSAN 权利人:DEB INDUBHUSAN 摘要:The present invention provides a new synthetic method for the preparation of building block indole-3-carboxylic acid (ICA) derivatives used as a key starting material to produce several artificial drugs. An efficient, safe, operationally simple, cost-effective method for the preparation of several ICA derivatives has been introduced in a very simple way. Utilizing easily available starting material, reagent, and solvent several key starting materials of ICA derivatives have been synthesized rapidly indicates the novel method is functional group tolerable. The preparation process does not involve use of any reducing agents or transition metals in the economically viable and operationally simple condition in one pot. ICA derivatives have been generated from isatin derivative in one step and this methodology is important with a wide range of applications from the drug development and material synthesis CN point of view.
专利号:WO-0053313-A2 优先权日:1999-03-09 标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries
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