CAS: 2058-74-4; 1-Methylindoline-2,3-Dione

该化合物是一种七环有机化合物,在2和3位置的1个位置和碳基组群中,以一档和碳基组群的一档和二等和三档的一色和碳基组取代一色骨,具有独特的反应性,使其成为合成有机化学中有价值的中间体,特别是用于制备药品和农用化学品.其僵硬的引信环系和缺电碳基组能够有选择地发挥作用,促进复杂分子的合成.该化合物在标准条件下的稳定性和与多种反应条件的兼容性增强了其在多步组合中的效用.它通常用于生物活性化合物的开发,包括动酶抑制剂和其他治疗剂.

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上下游产品

CAS号603-76-9 1-甲基吲哚 | CAS号91-56-5 靛红 | CAS号77-78-1 硫酸二甲酯 | CAS号74-88-4 碘甲烷 | CAS号1859-75-2 1-(2-(二甲基氨基)苯基)乙酮 | CAS号10336-55-7 1-[2-(二甲氨基)苯基]乙酮 | CAS号61-70-1 N-甲基-N-氧化吗啉 | CAS号75833-63-5 2-碘-1-甲基-1H-吲哚 | CAS号85092-84-8 3-碘-1-甲基-1H-吲哚 | CAS号180623-97-6 2,3-diiodo-1-me... | CAS号32387-21-6 1-甲基-3-吲哚酸 | CAS号121195-61-7 1-methyl-1H-ind... | CAS号1746-13-0 烯丙基苯基醚 | CAS号946-80-5 苄基苯基醚 | CAS号1910-68-5 美替沙腙 | CAS号603-76-9 1-甲基吲哚 | CAS号612-00-0 1,1-二苯基乙烷 | CAS号97207-47-1 甲异靛 | CAS号60434-13-1 5-氯-1-甲基吲哚啉-2,3-二酮 | CAS号100476-54-8 2-[4-(1,3-benzo...

合成工艺路线路线简述

  • 合成目标产物 N-Methylisatin 主要起始原料 Methyl Bromide And Isatin
  • (文献来源)合成步骤主要原料 Methyl Bromide 和 Isatin
📜2-氯-N-甲基-2-氧代-N-苯基乙酰胺 反应生成1-甲基靛红
参考文献:Stolle Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1930,Vol. <2>128,P. 1,23
标题:Stolle Et Al.,Journal Fur Praktische Chemie (Leipzig 1954),1930,Vol. <2>128,P. 1,23

海关参考信息

专利信息


专利号:US-9783496-B2
优先权日:2013-04-02
标 题 :Oxindole compounds, solvent-free synthesis and use thereof
发明人:BIJU AKKATTU THANKAPPAN; KAICHARLA TRINADH; YETRA SANTHIVARDHANA REDDY; ROY TONY
权利人:COUNCIL SCIENT IND RES
摘要:The present invention discloses oxindole compounds and a single step, one pot reaction for the synthesis of oxindole derivates via a solvent free Passerini reaction of isocyanides, isatins and carboxylic acids.

专利号:US-6753449-B2
优先权日:2001-10-09
标题 :Cleavable linker for solid phase synthesis
发明人:GUO MAOJUN
权利人:ARQULE INC
摘要:Cleavable alkene-containing linkers and supports useful for the solid phase synthesis of chemical compounds, and combinatorial libraries of compounds, are disclosed. Also disclosed are methods of making and using the linkers and supports.

专利号:US-2011263540-A1
优先权日:2008-07-25
标题 :Small-molecule inhibitors of protein synthesis inactivating toxins
发明人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
权利人:PANG YUAN-PING; TUMER NILGUN EREKEN; MILLARD CHARLES B
摘要:Small-molecule inhibitors of a protein synthesis inhibiting toxin, e.g., ricin, abrin, Shiga, and Shiga-like toxins, as well as methods of using the inhibitors are provided. Further provided are methods of identifying small-molecule inhibitors of a protein synthesis inhibiting toxin.

专利号:US-11440892-B2
优先权日:2019-07-03
标 题 :Substituted dihydrobenzoxazinones, dihydroquinolones, and methods of their use and synthesis
发明人:SCHEIDT KARL A; LEE ANSOO
权利人:UNIV NORTHWESTERN
摘要:Disclosed are dihydrobenzoxazinone compounds, dihydroquinolone compounds, and methods of their synthesis. The disclosed compounds may be prepared by reacting a benzoxazinedione compound and a ketone compound in the presence of an N-heterocyclic carbine (NHC) catalyst to perform a NHC-catalyzed decarboxylative cycloaddition. The disclosed compounds may be utilized to treat diseases and disorders associated with the biological activity of dihydrobenzoxazinone compounds and dihydroquinolone compounds.

专利号:US-2025236590-A1
优先权日:2021-10-20
标题 :A method for the preparation of indole-3-carboxylic acid derivatives
发明人:DEB INDUBHUSAN
权利人:DEB INDUBHUSAN
摘要:The present invention provides a new synthetic method for the preparation of building block indole-3-carboxylic acid (ICA) derivatives used as a key starting material to produce several artificial drugs. An efficient, safe, operationally simple, cost-effective method for the preparation of several ICA derivatives has been introduced in a very simple way. Utilizing easily available starting material, reagent, and solvent several key starting materials of ICA derivatives have been synthesized rapidly indicates the novel method is functional group tolerable. The preparation process does not involve use of any reducing agents or transition metals in the economically viable and operationally simple condition in one pot. ICA derivatives have been generated from isatin derivative in one step and this methodology is important with a wide range of applications from the drug development and material synthesis CN point of view.

专利号:WO-0053313-A2
优先权日:1999-03-09
标 题:Lanthanide catalysts for synthesis of compounds and combinatorial libraries

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✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: Hyatt Jl, Et Al. Selective Inhibition Of Carboxylesterases By Isatins, Indole-2,3-Diones. J Med Chem. 2007 Apr 19;50(8):1876-85.
[参考文献]: Mandal P, Et Al. Fluorescence Spectroscopic Characterization Of The Interaction Of Human Adult Hemoglobin And Two Isatins, 1-Methylisatin And 1-Phenylisatin: A Comparative Study. J Phys Chem B. 2009 Nov 12;113(45):14904-13.
[参考文献]: M S Mirrlees, Et Al. The Hydrolysis Of N-Methylisatin: On How A Simple Rate-Ph Profile May Mislead. Drug Des Discov. 1994 Apr;11(3):223-30.
[参考文献]: María C Rodríguez-Argüelles, Et Al. Complexes Of 2-Thiophenecarbonyl And Isonicotinoyl Hydrazones Of 3-(N-Methyl)Isatin. A Study Of Their Antimicrobial Activity. J Inorg Biochem. 2007 Jan;101(1):138-47.
[参考文献]: Paulami Mandal, Et Al. Fluorescence Spectroscopic Characterization Of The Interaction Of Human Adult Hemoglobin And Two Isatins, 1-Methylisatin And 1-Phenylisatin: A Comparative Study. J Phys Chem B. 2009 Nov 12;113(45):14904-13.

合成参考文献


参考文献:10.1107/s1600536811007124
摘要:Selvanayagam S, Ravikumar K, Saravanan P, Raghunathan R. 1',1''-Dimethyl-4'-(naphthalen-1-yl)-1,2,3,4-tetra-hydro-naphthalene-2-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-1,2''-dione. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr 01;67(Pt 4):o751.
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