CAS: 201530-41-8; 4-(3,5-Bis(2-Hydroxyphenyl)-1H-1,2,4-Triazol-1-yl)Benzoic Acid

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CAS号1311284-26-0 4,6-bis(2-((tri... | CAS号14685-90-6 4-肼基苯甲酸乙酯 | CAS号619-67-0 4-肼基苯甲酸 | CAS号1218-69-5 2-(2-羟基苯基)-4H-苯... | CAS号1972-71-0 2-羟基-N-(2-羟基苯基)苯甲酰胺 | CAS号69-72-7 水杨酸 | CAS号65-45-2 水杨酰胺 | CAS号1266741-05-2 地拉罗司甲酯

Deferasirox Methylamine Salt置于盐酸体系中,用 甲醇,水 用作溶剂,化学反应 0.5H,反应生成地拉罗司
参考文献: Process For Preparing 4-[3,5-Bis (2-Hydroxyphenyl)-Lh-L,2,4-Triazol-I-Yl] Benzoic Acid And Its Amine Salts[fr] Procédé Amélioré Pour La Préparation D'Un Composé Acide 4-[3,5-Bis(2-Hydroxyphényl)-1 H-1,2,4-Triazol-1-Yl]Benzoïque Et De Ses Sels D'Amine
标题: Process For Preparing 4-[3,5-Bis (2-Hydroxyphenyl)-Lh-L,2,4-Triazol-I-Yl] Benzoic Acid And Its Amine Salts[fr] Procédé Amélioré Pour La Préparation D'Un Composé Acide 4-[3,5-Bis(2-Hydroxyphényl)-1 H-1,2,4-Triazol-1-Yl]Benzoïque Et De Ses Sels D'Amine

专利信息

专利号:US-8907083-B2
优先权日:2010-08-25
标题 :Process for the preparation, of 2-(2-hydroxyphenyl)-benz [1, 3] oxazin-4-one and its use for preparation of 4-[3, 5-bis (2-hydroxyphenyl)-IH-I, 2, 4-triazolTI-yl] benzoic acid
发明人：DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; BATTHNI GURUSWAMY; MEDIDA CHANDRA MURTHY V R; DUMMU SANTHOSH
权利人:DAVULURI RAMAMOHAN RAO; PONNAIAH RAVI; BATTHNI GURUSWAMY; MEDIDA CHANDRA MURTHY V R; DUMMU SANTHOSH; RAMAMOHAN RAO DAVULURI
摘要:The invention provides a novel process for the synthesis of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one, the process comprising of reacting the salicylic acid with salicylamide in the presence of p-toluenesulfonyl chloride, base and solvent. The use of 2-(2-hydroxyphenyl)-benz[1,3]oxazin-4-one in the preparation of Deferasirox is also disclosed in the invention.

专利号:WO-2016203488-A1
优先权日:2015-06-16
标 题:Preparation of novel deferasirox analogues for antimalarial activity
发明人：HAVALDAR FREDDY H; DABHOLKAR BHUSHAN VASANT; MULE GANESH BABAN
权利人:HAVALDAR FREDDY H
摘要:The present invention relates to processes for the preparation of novel deferasirox analogues for antimalarial activity. The present invention further provides process for synthesis of novel deferasirox analogues.

专利号:US-9603928-B2
优先权日:2013-06-19
标题:Medicinal composition for promoting synthesis of protoporphyrin IX
发明人：ISHIZUKA MASAHIRO; OTO URARA; KAMIYA ATSUKO; TAKAHASHI KIWAMU; TANAKA TOHRU; OZAWA TOSHIYUKI; MORIMOTO KUNIYUKI; WATANABE KEITARO
权利人:SBI PHARMACEUTICALS CO LTD; UNIV OSAKA CITY
摘要:The object of the present invention is to elucidate the resistance mechanism in infections that show resistance to ALA-PDT that uses a single ALA, and to provide a novel treatment method against these infections. The present invention provides a pharmaceutical composition for promoting protoporphyrin IX production in ALA-PDT for treating infection, characterized in that it comprises a substance that promotes the conversion from coproporphyrinogen III to protoporphyrin IX.

专利号:WO-2016186940-A1
优先权日:2015-05-15
标 题 :Treatment of liver diseases with polyamine synthesis inhibitors
发明人：SU LISHAN; BILITY MOSES T
权利人:UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention relates to methods of inhibiting activation of M2-like macrophages in a subject, inhibiting liver inflammation and/or fibrosis, and treating liver diseases in a subject using polyamine synthesis inhibitors.

专利号:US-11744248-B2
优先权日:2017-08-20
标 题:Disinfectant composition for control of clostridium difficile spore
发明人：SMYTH BRUCE; BRALKOWSKI MICHAEL
权利人:SMYTH BRUCE; BRALKOWSKI MICHAEL; ENVIRO SPECIALTY CHEMICALS INC
摘要:A composition and method for inducing and inflicting damage to cell membranes of microorganism by inducing changes in membrane permeability caused by polycation-induced membrane pores. The control of Clostridium difficile spores with an efficacy of 99.99% on hard surfaces is provided. The invention includes the application of an evaporation-induced self-assembly, surfactant-mediated synthesis or self-condensing polymer, which forms a film which is both flexible on the surface as a nano-polymeric coating and with refractive index yielding a transparent coating. The polymeric matrix includes various biocidal polymeric cationic quaternary salts, one being a silyl quaternary having a kinetic zeta potential to disrupt bacterial spores functions. The polymeric matrix consist of multiple small molecule biocides as well as polymerics biocide combinations not otherwise seen to develop an surface topography of peaks and troughs in the nano range to resist bacterial adhesion factors and subsequent biofilm formation. The surfactants induce self-assembly film topography.

专利号:EP-3011972-A1
优先权日:2013-06-19
标题:Medicinal composition for promoting synthesis of protoporphyrin ix