CAS: 168173-56-6; 2-Bromo-5-(Chloromethyl)Pyridine
该化合物是一种多用途的七环环化合物,用作有机合成和制药应用的关键中间体,其活性溴和氯甲基功能组可进行选择性修改,使其对构建复杂的分子框架具有价值.该化合物在交叉反应,核循环代用品和作为生物活性分子的前体方面特别有用.在标准条件下保持稳定,确保了可靠的处理和储存.在高纯度和一贯性能的情况下,2-Bromo-5-(氯甲基)在药用化学和物质科学研究中受到青睐,用于开发具有定制特性的新化合物.
- 英文名称2-Bromo-5-(Chloromethyl)Pyridine
- 中文名称2-溴-5-(氯甲基)吡啶
- IUPAC名称2-bromo-5-(chloromethyl)pyridine
- 其它别名Pyridine, 2-Bromo-5-(Chloromethyl)- (9Ci); 2-Bromo-5-(Chloromethyl)Pyridine; Pyridine, 2-Bromo-5-(Chloromethyl)-; 7-(Diethylamino)-3-(1,3-Dimethylbenzimidazol-3-Ium-2-yl)Chromen-2-One,; 2-Fluoro-11-(Methylthio)Pyridine
- CAS编号168173-56-6
- MFCD编号:MFCD10697565
- 分子式:C6H5BrClN分子量:206.47
- 产品CID: 850194
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
3510-66-5 101990-45-8 1126779-39-2物理性质
MSDS等安全信息
上下游产品
2-bromo-5-(hydroxymethyl)pyridine 6-bromonicotinic acid 6-bromonicotinaldehyde(6-bromopyridine-3-yl)acetonitrile (E)-4-[2-(6-bromopyridin-3-yl)vinyl]-N,N-dimethylaniline 15H18N4C15H18N4合成工艺路线路线简述
📜2-溴-5-醛基吡啶置于sodium Tetrahydroborate,氯化亚砜体系中,用 乙醇,二氯甲烷 用作溶剂,化学反应 24.0H,反应生成2-溴-5-(氯甲基)吡啶
参考文献:A Copper Complex Of A Thiosemicarbazone-Pyridylhydrazone Ligand Containing A Vinylpyridine Functional Group As A Potential Imaging Agent For Amyloid-β Plaques
标题:A Copper Complex Of A Thiosemicarbazone-Pyridylhydrazone Ligand Containing A Vinylpyridine Functional Group As A Potential Imaging Agent For Amyloid-β Plaques
摘要:含有铜的正电子发射放射性核素的复合物有可能用于正电子发射断层扫描的诊断成像.阿尔茨海默病的特征是大脑中存在淀粉样β斑块.我们制备了一种带有吡啶-4-乙烯基吡啶官能团的新型硫代氨基脲-吡啶腙四价配体,目的是制造一种能与淀粉样β斑结合的铜复合物,以帮助诊断阿尔茨海默氏症.配体与铜(II)形成了电荷中性复合物,并通过 X 射线晶体学对其进行了表征,还通过循环伏安法研究了该复合物的电化学行为.新配体可在室温下用正电子发射铜-64 进行放射标记,放射化学收率极高.这种新复合物能与合成的淀粉样蛋白-β纤维相互作用,并能结合阿尔茨海默氏症死后脑组织中的淀粉样蛋白-β斑块.
Doi:10.1071/ch19311
海关参考信息
- 2933310010-吡啶
2903110000-一氯甲烷及氯乙烷
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-9839642-B2
优先权日:2014-05-09
标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors
发明人：TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
专利号:US-9856241-B2
优先权日:2013-07-03
标 题:Substituted benzofuranyl and benzoxazolyl compounds and uses thereof
发明人：BALOGLU ERKAN; SHACHAM SHARON; SENAPEDIS WILLIAM; MCCAULEY DILARA; LANDESMAN YOSEF; GOLAN GALI; KALID ORI; SHECHTER SHARON
权利人:KARYOPHARM THERAPEUTICS INC
摘要:The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula (A), or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
