专利号:US-2024294532-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds 发明人:TOMAS LOÃ?C; HARRIS CRAIG STEVEN 权利人:GALDERMA HOLDING S A 摘要:The present invention relates to processes and intermediates for the preparation of compounds useful as inhibitors of mechanistic target of rapamycin (mTOR).
专利号:EP-4370517-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:WO-2023285926-A1 优先权日:2021-07-12 标题 :Synthesis of chiral substituted pyrazolopyrimidine compounds
专利号:US-9328073-B2 优先权日:2011-05-25 标 题 :Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors 发明人:CUSHMAN MARK S; POMMIER YVES GEORGE 权利人:CUSHMAN MARK S; POMMIER YVES GEORGE; PURDUE RESEARCH FOUNDATION 摘要:The invention described herein pertains to substituted indenoisoquinoline compounds as described herein, wherein R A , R D , W, X and Y are defined herein, pharmaceutical compositions and formulations comprising the indenoisoquinoline compounds, their synthesis, and methods for their use in the treatment and/or prevention of cancer.
专利号:US-9682990-B2 优先权日:2011-05-25 标 题 :Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors 发明人:CUSHMAN MARK STANLEY; BECK DANIEL EDWARD 权利人:PURDUE RESEARCH FOUNDATION 摘要:The invention described herein pertains to substituted indenoisoquinoline compounds as described herein, wherein R A , R D , W, X and Y are defined herein, pharmaceutical compositions and formulations comprising the indenoisoquinoline compounds, their synthesis, and methods for their use in the treatment and/or prevention of cancer.
摘要:Zaidlewicz, M.; Pakulski, M. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 96. 摘要:Zaidlewicz, M.; Pakulski, M. M., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 65. 摘要:Matsunami, A.; Kayaki, Y.; Ikariya, T., Science of Synthesis: Catalytic Reduction in Organic Synthesis, (2018) 2, 64.