1-氨基-2-萘酚置于sodium Hydroxide,Air,Sodium Sulfite体系中,化学反应生成1-氨基-2-萘酚-4-磺酸 参考文献:Marschalk,Bulletin De La Societe Chimique De France,1929,Vol. <4> 45,P. 658 标题:Marschalk,Bulletin De La Societe Chimique De France,1929,Vol. <4> 45,P. 658
专利号:US-4929752-A 优先权日:1986-09-23 标题:Process for the preparation of 1-amine-2-naphthol-4-sulfonic acid 发明人:ALBRECHT BERNHARD; BEYRICH JUERGEN 权利人:CIBA GEIGY CORP 摘要:There is disclosed an improved semi-continuous and continuous process for the preparation of 1-amino-2-naphthol-4-sulfonic acid by nitrosation of 2-naphthol, addition of bisulfite, acidification with mineral acid and reduction of the reaction product so obtained, which comprises charging the reactor with the nitrosating agent and simultaneously adding 2-naphthol and mineral acid simultaneously in separate streams in the semi-continuous process, or charging the reactor with the reaction mass and simultaneously adding 2-naphthol, mineral acid and the nitrosating agent in separate streams in the continuous process. The product can be further used, without isolation, for the synthesis of dyes.
专利号:US-6359144-B1 优先权日:1997-02-04 标 题 :Combinatorial libraries of bicyclic guanidine derivatives and compounds therein 发明人:OSTRESH JOHN M; MEYER JEAN-PHILIPPE; DOOLEY COLETTE T; BLONDELLE SYLVIE E; SCHONER CHRISTA C; HOUGHTEN RICHARD A 权利人:LION BIOSCIENCE AG 摘要:The invention provides a rapid approach for combinatorial synthesis and screening of combinatorial libraries of bicyclic guanidine compounds. The present invention further provides the compounds made by the combinatorial synthesis and individually as well as methods of using the same.
专利号:US-5376151-A 优先权日:1993-04-16 标题 :Environmentally friendly method for producing lightfast black shades on natural and synthetic substrates 发明人:FREEMAN HAROLD S; REIFE ABRAHAM; SOKOLAWSKA-GAJDA JOLANTA 权利人:UNIV NORTH CAROLINA STATE 摘要:Disclosed is an original approach to solving the environmental problem associated with the use of Cr-based metallized azo dyes to deliver black shades on natural and synthetic substrates. This invention affords methods for both the synthesis of metallized dyes and the generation of black dyeings using those dyes without employing metals designated as priority pollutants at any stage in either method. The key element of the disclosure is the use of black 1:2 Fe complexes of azo dyes in lieu of currently used Cr-based complexes which are based on environmentally unfriendly priority pollutant metals without compromising the desirable high fastness properties of the latter complexes, an accomplishment heretofore assumed unachievable.
专利号:CN-101092380-A 优先权日:2007-07-11 标题 :Preparation method for homogeneous synthesis of 1,2,4-acid in water-alcohol solvent
专利号:CN-117186665-A 优先权日:2023-08-26 标题 :A zinc-free synthesis method of C.I. acid blue 193
参考文献:10.1023/a:1015069424251 摘要:Karaseva EI, Losev IuP, Metelitsa DI. [Peroxidase-catalyzed oxidation of 3,3',5,5'-tetramethylbenzidine in the presence of 2,4-dinitrosoresorcinol and polydisulfide derivatives of resorcinol and 2,4-dinitrosoresorcinol]. Bioorg Khim. 2002 Mar;28(2):147–55. doi: 10.1023/a:1015069424251. 参考文献:10.1007/s00248-003-1041-8 摘要:Lepp PW, Schmidt TM. Changes in Synechococcus population size and cellular ribosomal RNA content in response to predation and nutrient limitation. Microb Ecol. 2004 Jul;48(1):1–9. doi: 10.1007/s00248-003-1041-8. 参考文献:10.1021/jm301544x 摘要:Sosič I, Mirković B, Arenz K, Stefane B, Kos J, Gobec S. Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives. J Med Chem. 2013 Jan 24;56(2):521–33. doi: 10.1021/jm301544x.