CAS: 10531-50-7; (R)-2,2,2-Trifluoro-1-Phenylethanol

相似化合物

340-05-6 340-06-7 434-45-7

上下游产品

CAS号434-45-7 α,α,α-三氟苯乙酮 | CAS号81290-20-2 (三氟甲基)三甲基硅烷 | CAS号100-52-7 苯甲醛 | CAS号617-35-6 丙酮酸乙酯 | CAS号15206-55-0 苯甲酰甲酸甲酯 | CAS号1445-91-6 (S)-(-)-1-苯基乙醇 | CAS号340-04-5 α-(三氟甲基)苄醇 | CAS号84194-69-4 (±)-2,2,2-trifl...

📜2,2,2-三氟苯乙酮置于苯硅烷体系中,用 Aq. Buffer 用作溶剂,化学反应 3.0H,以99%的收率获得(R)-(-)-α-(三氟甲基)苄醇
参考文献:碳酸酐酶通过酶促氢化锌催化硅烷非生物还原酮
标题:碳酸酐酶通过酶促氢化锌催化硅烷非生物还原酮
摘要:尽管在合成过渡金属催化剂的反应中普遍存在此类中间体,但通过单核金属氢化物的酶促反应在自然界中是未知的.如果金属酶可以通过这样的非生物中间体发生反应,那么酶催化反应的范围将会扩大.在这里,我们展示了含锌碳酸酐酶以高对映选择性催化氢化物从硅烷到酮的转移.我们报告的机械数据提供了强有力的证据,表明该过程涉及单核氢化锌.这项工作表明,非生物硅烷可以在酶催化过程中充当还原当量,并且在质子环境中通常不稳定的正电金属的单体氢化物可以作为酶促过程中的催化中间体.总体,
Doi:10.1038/s41557-020-00633-7

专利信息

专利号:US-5932726-A
优先权日:1996-12-16
标 题 :Asymmetric synthesis of benzoxazinones
发明人：PIERCE MICHAEL ERNEST; CHOUDHURY ANUSUYA; PARSONS JR RODNEY LAWRENCE; RADESCA LILIAN ALICIA
权利人:DU PONT PHARM CO
摘要:The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) ##STR1## which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-6040480-A
优先权日:1997-04-07
标题 :Asymmetric synthesis of benzoxazinones
发明人：PIERCE MICHAEL E; CHEN CHENG Y; CHOUDHURY ANUSUYA; RADESCA LILIAN A; TAN LUSHI; ZHAO DALIAN
权利人:DU PONT PHARM CO
摘要:The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-7462738-B2
优先权日:2006-05-24
标题:Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
发明人：HEDVATI LILACH; GILBOA EYAL; AVHAR-MAYDAN SHARON
权利人:TEVA PHARMA
摘要:Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.

专利号:US-3880943-A
优先权日:1963-08-12
标 题:Highly fluorinated organic compounds and synthesis of perfluorostyrene
发明人：WALL LEO A; ANTONUCCI JOSEPH M
权利人:US NAVY
摘要:New fluorinated substituted ethylenic compounds which are 2,3,4,5,6-pentafluoro- Alpha -(trifluoromethyl) benzyl alcohol, (1,2,2,2-tetrafluoroethyl)perfluorobenzene and (1-bromo-1,2,2,2tetrafluoroethyl)perfluorobenzene. The new compounds are useful as intermediates in the preparation of perfluorostyrene. Pyrolysis of the aforesaid perfluorobenzenes gives perfluorostyrene and of the first of these perfluorobenzenes, Alpha -hydroheptafluorostyrene, also.

专利号:US-6203721-B1
优先权日:1996-11-15
标题 :Compounds useful for perhalogenoalkylation, reagent for implementing these compounds and synthesis method for obtaining these compounds
发明人：ROQUES NICOLAS; RUSSELL JAMES; LANGLOIS BERNARD; SAINT-JALMES LAURENT; LARGE SYLVIE
权利人:RHODIA CHIMIE SA
摘要:The invention concerns a reagent and a family of compounds. The reagent contains by successive or simultaneous addition: a material of formula RfH, a silicophilic base, a trivalent nitrogenous derivative containing no hydrogen and at least two silyl groups. The invention is useful for organic synthesis.

专利号:WO-2024261157-A1
优先权日:2023-06-21
标 题 :A solid support for use in solid phase peptide synthesis
发明人：BADIANI KAMAL; TURNER STEPHEN JOHN
权利人:PEPCEUTICALS LTD
摘要:The present invention relates to a solid support for use in solid phase peptide synthesis (SPPS) and to a method of manufacturing a support for use in SPPS as well as the use of such solid support in 5 SPPS. The present invention also relates to a protected amino acid for use in SPPS.