CAS: 782487-28-9; (1S,3S,4R)-4-((3As,4R,5S,7As)-4-(Aminomethyl)-7A-Methyl-1-Methyleneoctahydro-1H-Inden-5-yl)-3-(Hydroxymethyl)-4-Methylcyclohexanol
该化合物是化学化合物,主要针对其潜在的治疗用途进行研究,属于一类物质,以其在生物途径调节过程中的作用而著称,特别是在代谢紊乱的情况下;化合物具有可能影响脂质代谢和葡萄糖足部固态的特性,使其对肥胖和2型糖尿病等病症的治疗感兴趣;Rosiptor的行动机制通常涉及与管理代谢过程的特定受体或酶的相互作用;与许多制药化合物一样,通过临床试验评估其功效和安全特征,评估其药理,药理动力学和潜在副作用;化合物的特性,包括溶性,稳定性和再活性,对于其在治疗环境中的配制和提供至关重要;
- 英文名称(1S,3S,4R)-4-((3As,4R,5S,7As)-4-(Aminomethyl)-7A-Methyl-1-Methyleneoctahydro-1H-Inden-5-yl)-3-(Hydroxymethyl)-4-Methylcyclohexanol
- 中文名称罗西普托
- IUPAC名称(1S,3S,4R)-4-((3aS,4R,5S,7aS)-4-(aminomethyl)-7a-methyl-1-methyleneoctahydro-1H-inden-5-yl)-3-(hydroxymethyl)-4-methylcyclohexan-1-ol
- CAS编号782487-28-9
- MFCD编号:MFCD31619271
- FDA UNII编号:6R5034F862
- 分子式:C20H35NO2分子量:321.51
- 产品CID: 1777698
- 同类组份化合物CAS782487-29-0 (acetate)782487-28-9 (free base)
- 产品分类原料药 → 激素及调节内分泌功能类药 → 胰腺激素及其它调节血糖药
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜去氢表雄酮置于咪唑,盐酸,甲醇,叔丁基过氧化氢,4-二甲氨基吡啶,Lithium Aluminium Tetrahydride,正丁基锂,Ruthenium(Iii) Chloride Trihydrate,Palladium 10% On Activated Carbon,氨,水,氢气,对甲苯磺酸,臭氧,三乙胺体系中,用 四氢呋喃,二氯甲烷,环己烷,水,乙酸乙酯,N,N-二甲基甲酰胺,苯 作为反应溶剂,-78.0~20.0 °C,101.33 Kpa 条件下,反应 201.33H,反应生成 罗西普托
参考文献:Synthetic Studies On The Indane Ship1 Agonist Aqx-1125
标题:Synthetic Studies On The Indane Ship1 Agonist Aqx-1125
摘要:开发了一种新的基于茚烷的ship1激动剂aqx-1125的合成方法.测试aqx-1125和一些类似物提供了有关药效团和生物活性的信息.
DOI:10.1039/d2Ob00555G
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10053415-B2
优先权日:2016-01-20
标题:Synthesis of a substituted indene derivative
发明人：HARWIG CURTIS; SEENISAMY JEYAPRAKASHNARAYANAN; KEREGADDE MAHESH NARAYAN; CHETIA LAKSHINDRA
权利人:AQUINOX PHARMACEUTICALS CANADA INC
摘要:This invention is directed to methods of preparing AQX-1125 having the formula: n n n n n n n n n n This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
专利号:AU-2017209430-A1
优先权日:2016-01-20
标 题:Synthesis of a substituted indene derivative
专利号:US-2017204048-A1
优先权日:2016-01-20
标 题:Synthesis of a substituted indene derivative
专利号:WO-2017127753-A1
优先权日:2016-01-20
标题:Synthesis of a substituted indene derivative
专利号:US-2018086691-A9
优先权日:2016-01-20
标 题:Synthesis of a substituted indene derivative
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Nickel JC, Egerdie B, Davis E, Evans R, Mackenzie L, Shrewsbury SB. A Phase II Study of the Efficacy and Safety of the Novel Oral SHIP1 Activator AQX-1125 in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome. J Urol. 2016 Sep;196(3):747-54. doi: 10.1016/j.juro.2016.03.003. Epub 2016 Mar 9. doi: 10.1517/13543784.2016.1162290. Epub 2016 Mar 22. doi: 10.1111/cea.12370. doi: 10.1111/bph.12039.
5: Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Chernoff D, MacRury T, Szabo C. Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol. 2013 Mar;168(6):1519-29. doi: 10.1111/bph.12038.
6: Croydon L. BioPartnering North America--Spotlight on Canada. IDrugs. 2010 Mar;13(3):159-61.
合成参考文献
摘要:S55 | ZINC15PHARMA | Pharmaceuticals from ZINC15 | DOI:10.5281/zenodo.3247749
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