CAS: 727728-51-0; 5-(4-Methoxyphenyl)-1-Oxa-3-Azaspiro[5.5]Undecane

相似化合物

93413-70-8 93413-56-0 1346601-55-5

上下游产品

formaldehyd N,N-didesmethylvenlafaxine p-methoxybenzylnitrile cyclohexanol 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexanol

📜对甲氧基苯乙腈置于镍 Sodium Hydroxide,四丁基溴化铵,氨,氢气体系中,用 甲醇,水 作为反应溶剂,25.0~40.0 °C,1.01 Mpa 条件下,反应 21.0H,反应生成 文拉法辛杂质13
参考文献:Simple And An Efficient Method For The Synthesis Of 1-[2-Dimethylamino-1-(4-Methoxy-Phenyl)-Ethyl]-Cyclohexanol Hydrochloride: (+/-) Venlafaxine Racemic Mixtures
标题:Simple And An Efficient Method For The Synthesis Of 1-[2-Dimethylamino-1-(4-Methoxy-Phenyl)-Ethyl]-Cyclohexanol Hydrochloride: (+/-) Venlafaxine Racemic Mixtures
摘要:A Novel Synthetic Method Was Developed For The Synthesis Of Venlafaxine Using Inexpensive Reagents. An Improvement In The Method,In The Yield Was Achieved For The Conversion Of The Venlafaxine. This Is An Improved Version,Simple And Efficient Method For The Large-Scale Synthesis Of Venlafaxine. (C) 2004 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2004.03.098