CAS: 7051-15-2; 2-Chloro-1,3-Dimethoxybenzene

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CAS号6201-65-6 2-氯-1,3-苯二酚 | CAS号74-88-4 碘甲烷 | CAS号1466-76-8 2,6-二甲氧基苯甲酸 | CAS号67-72-1 六氯乙烷 | CAS号151-10-0 间苯二甲醚 | CAS号116-16-5 六氯丙酮 | CAS号2785-97-9 lithium,1,3-dim... | CAS号16932-45-9 2,6-二甲氧基溴苯 | CAS号77-78-1 硫酸二甲酯 | CAS号72482-14-5 3-氯-2,4-二甲氧基苯甲醛 | CAS号72498-57-8 ((7-chloro-3-(2... | CAS号90247-08-8 8-chloro-3-(2-f...

📜间苯二甲醚置于正丁基锂,六氯乙烷体系中,化学反应生成 2,6-二甲氧基-氯苯
参考文献:[(3-芳基-1,2-苯并恶唑-6-基)氧基]乙酸.新的利尿剂系列.
标题:[(3-芳基-1,2-苯并恶唑-6-基)氧基]乙酸.新的利尿剂系列.
摘要:合成了一系列的[(3-芳基-1,2-苯并恶唑-6-基)氧基]乙酸,并测试了在有盐负荷的小鼠和有意识的有水负荷的狗中的利尿活性.发现在小鼠和狗中非常好的利尿活性的结构要求非常具体.总之,具有最佳利尿活性的化合物(13I,13Q和13Ff)在3位被2-氟苯基取代,在7位被氯或溴取代.发现化合物13Ff [[7-溴-3-(2-氟苯基)-1,2-苯并恶唑-6-基]氧基]乙酸(hp 522)在黑猩猩中具有中等尿酸尿酸,因此被选择用于进一步开发.
DOI:10.1021/jm00343A008

专利信息

专利号:WO-0208446-A9
优先权日:2000-07-13
标题 :Synthesis and antiviral evaluation of nucleic acid based (nab) libraries
发明人：IYER RADHAKRISHNAN P; ZHOU WENQIANG; JIN YI; ROLAND ARLENE; LYAKU JAPHET
权利人:ORIGENIX TECHNOLOGIES INC
摘要:The present invention provides for compositions and methods to generate a library of small molecules that mimic the repertoire of interactions that exist amongst nucleic acids, and proteins, as well as, that which exist between proteins and nucleic acids. The designed library of nucleoside analogs are for use as competitive and non-competitive viral replication inhibitors or serve as pro-drugs of inhibitors in anti-viral drug discovery. A facile parallel solution-phase chemistry has been developed to carry out the combinatorial synthesis of nucleoside analogs as a source of pharmacore-based chemical diversity.

专利号:EP-0067342-A1
优先权日:1981-06-04
标 题 :Process for the preparation of 2-chloro-1,3-dimethoxybenzene
发明人：SHUTSKE GREGORY MICHAEL; LEE THOMAS BING KIN DR; JOBIN GREGORY MICHAEL
权利人:HOECHST ROUSSEL PHARMA
摘要:An improved process for the preparation of 2-chloro-1,3-dimethoxybenzene involving the conversion of 1,3-dimethoxybenzene to [2,6-dimethoxyphenyl]-lithium and the reaction of this compound with a chlorinating agent is disclosed. 2-Chloro-1,3-dimethoxybenzene is useful as starting material for the synthesis of pharmacologically valuable 1,2-benzisoxazoloxy acetic acids.

专利号:US-4579981-A
优先权日:1981-06-04
标题:Process for the preparation of 2-chloro-1,3-dimethoxybenzene
发明人：SHUTSKE GREGORY M; LEE THOMAS B K; JOBIN GREGORY M
权利人:HOECHST ROUSSEL PHARMA
摘要:An improved process for the preparation of 2-chloro-1,3-dimethoxybenzene involving the reaction of [2,6-dimethoxyphenyl]lithium with chlorinating agents is disclosed. 2-Chloro-1,3-dimethoxybenzene is useful as a starting material for the synthesis of pharmacologically valuable 1,2-benzisoxazoloxyacetic acids.

专利号:US-9890125-B2
优先权日:2013-01-08
标 题:Syntheses of N-heterocyclic carbenes and intermediates therefor
发明人：NOLAN STEVEN P; MEIRIES SEBASTIEN
权利人:UNIV COURT UNIV ST ANDREWS
摘要:A method of preparing a 2,6 disubstituted anilines includes, reacting a 2-amino isophthalic acid diester with sufficient Grignard reagent R 2 CH 2 MgX to form the corresponding diol product, dehydrating the diol product to the corresponding dialkene; and hydrogenating the diol product to form the corresponding aniline. The 2,6 disubstituted anilines can be used to produce N-Heterocyclic Carbenes (NHCs). The NHCs can find application in various fields such as organic synthesis, catalysis and macromolecular chemistry. Palladium catalysts containing the NHCs are also described.

专利号:US-9006491-B2
优先权日:2009-10-22
标题 :Structure and method for synthesizing and using dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate
发明人：MA SHENGMING; LÃœ BO; FU CHUNLING
权利人:MA SHENGMING; LÃœ BO; FU CHUNLING; UNIV ZHEJIANG
摘要:The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate. Moreover, with this type of ligands, the Suzuki coupling products of optically active chlorolactones and arylboronic acids would maintain their configuration and optical purity.

专利号:JP-7199401-B2
优先权日:2013-01-08
标题:Synthesis of N-heterocyclic carbenes and their intermediates