专利号:US-5041637-A 优先权日:1988-07-12 标题:Process for the synthesis of optically active aminoacids 发明人:CANNATA VINCENZO; TAMERLANI GIANCARLO; CALZOLARI CLAUDIO 权利人:PRESIDENZA DEL CONSIGLIO DEL M 摘要:New process for the synthesis of optically active aminoacids of formula ##STR1## by treating compounds of formula ##STR2## which an optically active alcohol of formula n n R.sub.4 --OH (III) n n n d or 1 n n To obtain a pair of diastereoiosmer esters of formula ##STR3## which is resolved in basic medium into the single diastereoisomer esters of formula ##STR4## from which the desired optically active aminoacid of formula (I) is obtained by treatment in acid medium.
专利号:US-9018371-B2 优先权日:2007-03-07 标 题 :Adenosine derivatives, method for the synthesis thereof, and the pharmaceutical compositions for the prevention and treatment of the inflammatory diseases containing the same as an active ingredient 发明人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH 权利人:JEONG LAK SHIN; KIM HEA OK; JACOBSON KENNETH A; CHOE SEUNG AH; FM THERAPEUTICS CO LTD; US OF AMERICA AS REPRESENTED BY THE SECRETARY DEPT OF HEALTH AND HUMAN SERVICES THE OFFICE OF TECHNO 摘要:Disclosed are adenosine derivatives, methods for the synthesis thereof, and pharmaceutical compositions for the prevention and treatment of inflammatory diseases, comprising the same as an active ingredient. The adenosine derivatives have high binding affinity and selectivity for adenosine receptors, especially for A 3 adenosine receptors and act as A 3 adenosine receptor antagonists, and exhibit anti-inflammatory activity. Thus, the adenosine derivatives are useful in the prevention and treatment of inflammatory diseases.
专利号:US-8058424-B2 优先权日:2003-03-17 标题:Synthesis of 5-azacytidine 发明人:IONESCU DUMITRU; BLUMBERGS PETER 权利人:IONESCU DUMITRU; BLUMBERGS PETER; PHARMION LLC 摘要:The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: n n n n n n n n n n The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).
专利号:US-2004186283-A1 优先权日:2003-03-17 标题:Synthesis of 5-azacytidine
专利号:US-2009005551-A1 优先权日:2003-03-17 标题 :Synthesis of 5-azacytidine
专利号:US-2006247432-A1 优先权日:2003-03-17 标 题:Synthesis of 5-Azacytidine
参考文献:10.1186/2047-783x-14-s4-275 摘要:Matakova T, Sivonova M, Halasova E, Mistuna D, Dzian A, Berzinec P, Letkova L, Dobrota D. Gene polymorphisms of biotransforming enzymes (GSTs) and their association with lung cancer in the Slovakian population. European Journal of Medical Research. 2009 Dec 07;14(Suppl 4):275. doi: 10.1186/2047-783x-14-s4-275. 参考文献:10.1007/s10295-005-0062-3 摘要:Liu Y, Sha Q, Wu S, Wang J, Yang L, Sun W. Enzymatic resolution of racemic phenyloxirane by a novel epoxide hydrolase from Aspergillus niger SQ-6 and its fed-batch fermentation. Journal of Industrial Microbiology & Biotechnology. 2005 Dec 01;33(4):274–82. doi: 10.1007/s10295-005-0062-3. 参考文献:10.1186/1476-511x-10-116 摘要:An HM, Park SY, Lee DK, Kim JR, Cha MK, Lee SW, Lim HT, Kim KJ, Ha NJ. Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats. Lipids in Health and Disease. 2011 Jul 12;10(1):116. doi: 10.1186/1476-511x-10-116. 参考文献:10.1007/s00425-005-0175-y 摘要:Nardi MC, Feron R, Navazio L, Mariani P, Pierson E, Wolters-Arts M, Knuiman B, Mariani C, Derksen J. Expression and localization of calreticulin in tobacco anthers and pollen tubes. Planta. 2006 May;223(6):1263–71. doi: 10.1007/s00425-005-0175-y. 参考文献:10.1007/s00436-011-2509-y 摘要:Najm NA, Silaghi C, Bell-Sakyi L, Pfister K, Passos LM. Detection of bacteria related to Candidatus Midichloria mitochondrii in tick cell lines. Parasitol Res. 2012 Jan;110(1):437–42. doi: 10.1007/s00436-011-2509-y.