专利号:US-12194020-B2 优先权日:2017-12-22 标 题:Reversing baldness through cannabinoid receptor activation 发明人:POSTREL RICHARD 权利人:POSTREL RICHARD 摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.
专利号:US-2013164265-A1 优先权日:2011-12-21 标题 :Skin care compositions 发明人:FLAVIN DANA; OBENLAND SIGRID 权利人:FLAVIN DANA; OBENLAND SIGRID 摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.
专利号:US-2014328952-A1 优先权日:2011-12-21 标题:Topical compositions 发明人:FLAVIN DANA 权利人:FLAVIN DANA 摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.
专利号:CN-1651384-A 优先权日:2004-11-27 标题 :Synthesis method of glycyrrhizin
专利号:US-8790720-B2 优先权日:2011-12-22 标题:Compositions and methods for treating skin 发明人:RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL 权利人:PROCTER & GAMBLE 摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.
[参考文献]: J Thomas Sanderson, Et Al. Induction And Inhibition Of Aromatase (Cyp19) Activity By Natural And Synthetic Flavonoid Compounds In H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2004 Nov;82(1):70-9. [参考文献]: Sanderson Jt, Et Al. Induction And Inhibition Of Aromatase (Cyp19) Activity By Natural And Synthetic Flavonoid Compounds In H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2004 Nov;82(1):70-9.
合成参考文献
参考文献:10.1093/toxsci/kfh257 摘要:Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70–9. doi: 10.1093/toxsci/kfh257.