CAS: 6515-36-2; 7-Hydroxyflavanone

该化合物是一个氟芳烃化合物,其特征是其芳烃结构,由七点方块组成的铬脊柱和氢氧基组组成;该化合物一般呈现出黄色至白色晶状,在乙醇和甲醇等有机溶剂中可溶解,但在水中可溶性有限.7-Hydroxyflavanone因其潜在的生物活动而闻名,包括抗氧化剂,抗炎和抗微生物特性,因此对药理学和营养学研究感兴趣.氢氧基组的存在增强了其活动性和与各种生物目标互动的能力.此外,它可能在植物防御机制中发挥作用,并研究其在人类营养方面的潜在健康惠益.与许多氟芳基生物一样,其稳定性可能受到诸如光和pH等环境因素的影响,这些环境因素可能影响其生物系统的生物利用率和功效.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

Cinnamoyl chloride recorcinol (E)-2',4'-dihydroxychalcone 7-methoxyflavanone 4-oxo-2-phenylchroman-7-yl acetate 7-hydroxy-8-(3-methylbut-2-en-1-yl)-2-phenylchroman-4-one 7-(γ,γ-dimethylallyloxy)flavanone 7-hydroxy-6-C-prenylflavanone

合成工艺路线路线简述

  • 合成目标产物 7-Hydroxyflavanone 主要起始原料 2',4'-Dihydroxychalcone
  • (文献来源)合成步骤主要原料 2',4'-Dihydroxychalcone
📜7-(Methoxymethoxy)-2-Phenylchroman-4-One置于盐酸,水体系中,化学反应生成 7-羟基黄烷酮
参考文献:7-戊烯氧基-2,3-二氢黄酮酮衍生物的设计,合成和潜在的类抗抑郁药活性
标题:7-戊烯氧基-2,3-二氢黄酮酮衍生物的设计,合成和潜在的类抗抑郁药活性
摘要:合成了一系列7-戊烯氧基-2,3-二氢黄酮衍生物,并筛选了它们的抗抑郁样活性.在这些化合物中,发现化合物5J和5K具有最抗抑郁样的活性.此外,还发现化合物5J和5K显着增加了海马,下丘脑和皮层中主要神经递质5-Ht和ne的浓度.与用应激载体治疗的小鼠相比,化合物5J和5K还显着增加了海马和皮层中5-Hiaa的含量,关闭了5-Ht代谢.这些结果表明化合物5J和5K 显示出通过神经化学系统介导的强效抗抑郁药性质.
DOI:10.1111/cbdd.12717

海关参考信息

专利信息


专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人:POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.

专利号:US-2013164265-A1
优先权日:2011-12-21
标题 :Skin care compositions
发明人:FLAVIN DANA; OBENLAND SIGRID
权利人:FLAVIN DANA; OBENLAND SIGRID
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:US-2014328952-A1
优先权日:2011-12-21
标题:Topical compositions
发明人:FLAVIN DANA
权利人:FLAVIN DANA
摘要:This invention provides compositions and methods of manufacturing such compositions that employ GRAS compounds which can act to promote the generation of stem, epidermal or other skin cells in the epidermis, activation of collagen synthesis, activation of hyaluronic acid synthesis, enhanced skin hydration, and dermal healing by stimulating stem cell and fibroblast migration to sites of needed repair. These compositions and methods are useful for rejuvenating the skin and for treating some skin-related aging or other dermal damaging conditions, including wrinkle reduction and treatment of minor dermal wounds.

专利号:CN-1651384-A
优先权日:2004-11-27
标题 :Synthesis method of glycyrrhizin

专利号:US-8790720-B2
优先权日:2011-12-22
标题:Compositions and methods for treating skin
发明人:RICHARDS JEANETTE ANTHEA; DAWSON THOMAS LARRY; COMBS MARY JANE; DUEVA-KOGANOV OLGA; KOGANOV MICHAEL
权利人:PROCTER & GAMBLE
摘要:The present invention relates to skin care compositions comprising blends of camellia and feverfew serum fractions and/or kelp and parsley serum fractions. The skin care compositions also comprise a dermatologically acceptable carrier. The invention also relates to methods for increasing melanin production in skin by topically applying the skin care composition to areas in order to stimulate one or more steps in melanin synthesis and/or interrupt an inflammatory cycle.

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

[参考文献]: J Thomas Sanderson, Et Al. Induction And Inhibition Of Aromatase (Cyp19) Activity By Natural And Synthetic Flavonoid Compounds In H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2004 Nov;82(1):70-9.
[参考文献]: Sanderson Jt, Et Al. Induction And Inhibition Of Aromatase (Cyp19) Activity By Natural And Synthetic Flavonoid Compounds In H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2004 Nov;82(1):70-9.

合成参考文献


参考文献:10.1093/toxsci/kfh257
摘要:Sanderson JT, Hordijk J, Denison MS, Springsteel MF, Nantz MH, van den Berg M. Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells. Toxicol Sci. 2004 Nov;82(1):70–9. doi: 10.1093/toxsci/kfh257.
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