CAS: 58534-95-5; 3-Bromo-2-Fluoroaniline

上下游产品

CAS号58534-94-4 2-氟-3-溴硝基苯

2-氟-3-溴硝基苯置于铁粉,氯化铵,溶剂黄146体系中,用 乙醇,水 作为反应溶剂,以93%的收率获得产物3-溴-2-氟苯胺
参考文献:发现一种有效的选择性 Cbp 溴结构域抑制剂 (y08262) 治疗急性髓性白血病
标题:发现一种有效的选择性 Cbp 溴结构域抑制剂 (y08262) 治疗急性髓性白血病
摘要:Creb (cyclic-Amp Response Element Binding Protein) 结合蛋白 (cbp) 的溴结构域是表观遗传学"读取器",在转录调控中起关键作用.cbp 溴结构域被认为是急性髓性白血病 (aml) 的一个有前途的治疗靶点.在此,我们报道了一系列 1-(吲哚嗪-3-基)乙-1-酮衍生物的发现,这些衍生物是专注于提高细胞效力的有效和选择性 Cbp 溴结构域抑制剂.最有前途的化合物之一 7E (y08262) 在纳摩尔水平 (ic50 = 73.1 Nm) 抑制 Cbp 溴结构域,具有显著的选择性.此外,新抑制剂在 Aml 细胞系中也显示出有效的抑制活性.总的来说,本研究为进一步验证 Cbp 溴结构域作为 Aml 药物开发的分子靶点提供了一种新的先导化合物.
DOI:10.1016/j.Bioorg.2023.106950

专利信息

专利号:US-10711011-B2
优先权日:2016-05-20
标题 :Substituted oxazolidines as anti-bacterial agents
发明人：PEER MOHAMED SHAHUL HAMEED; BHARATHAM NAGAKUMAR; KATAGIHALLIMATH NAINESH; SHARMA SREEVALLI; NANDISHAIAH RADHA
权利人:BUGWORKS RES INC
摘要:The present disclosure relates to compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms thereof and pharmaceutical compositions containing them as the active ingredient which can be used as medicaments. The aforementioned substances can also be used in the manufacture of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also relates to the synthesis and characterization of aforementioned substances.