专利号:US-9051302-B2 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents 发明人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN 权利人:WINSSINGER NICOLAS; BARLUENGA SOFIA; KARPLUS MARTIN; UNIV STRASBOURG 摘要:Disclosed are macrocyclic compounds of formulae I, I′, II, II′, III, III′, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.
专利号:WO-2022228297-A1 优先权日:2021-04-26 标 题:Enzymatic preparation technique for acyl/aroyl coenzyme a 发明人:ZHU PING; ZHANG BOYONG; WANG HAO; GONG TING; CHEN TIANJIAO; CHEN JINGJING; YANG JINLING 权利人:INST OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCICENCES 摘要:Provided are a method for large-scale preparation of acyl/aroyl coenzyme A by an enzymatic method, i.e., using an acyltransferase to transfer acyl/aroyl from a cheap acyl/aroyl donor onto acyl/aroyl receptor coenzyme A, thereby achieving large-scale synthesis of acyl/aroyl coenzyme A, and a use of the method in the preparation of acyl/aroyl coenzyme A.
专利号:US-10239856-B2 优先权日:2008-01-15 标题:Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:CN-101990399-B 优先权日:2008-01-15 标 题:Synthesis of dihydroxybenzoic acid lactones as therapeutic agents
专利号:US-2011217335-A1 优先权日:2008-01-15 标 题 :Synthesis of resorcylic acid lactones useful as therapeutic agents
专利号:US-4897380-A 优先权日:1985-08-30 标 题 :Method and composition for relieving dietary-related disorders 发明人:POLLACK ROBERT L; DURST LAWRENCE 权利人:POLLACK ROBERT L; DURST LAWRENCE 摘要:A composition for treating physiological disorders responsive to treatment with the neurotransmitter serotonin includes L-tryptophan, fructose, niacinamide, pyridoxine, calcium ascorbate, copper gluconate and magnesium oxide. Each ingredient either promotes the transport of L-tryptophan from the blood plasma across the blood-brain barrier into the brain, or promotes the synthesis of serotonin from L-tryptophan.
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