CAS: 556-08-1; 4-Acetamidobenzoic Acid

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CAS号150-13-0 对氨基苯甲酸 | CAS号64-19-7 冰醋酸 | CAS号108-24-7 乙酸酐 | CAS号103-89-9 4-甲基乙酰苯胺 | CAS号122-85-0 对乙酰氨基苯甲醛 | CAS号532-32-1 苯甲酸钠 | CAS号141-78-6 乙酸乙酯 | CAS号75-36-5 乙酰氯 | CAS号507-09-5 硫代乙酸 | CAS号10602-00-3 4-乙炔基苯甲酸 | CAS号50-86-2 4-乙酰氨基水杨酸 | CAS号4123-72-2 4-氨基-3,5-二溴苯甲酸 | CAS号94-25-7 4-氨基苯甲酸丁酯 | CAS号190071-24-0 4-乙酰氨基-3-碘苯甲酸 | CAS号2857-03-6 [(4-Acetylamino... | CAS号56961-25-2 4-氨基-3,5-二氯苯甲酸 | CAS号2486-71-7 4-氨基-3-氯苯甲酸 | CAS号709-19-3 2-甲基-3H-苯并咪唑-5-羧酸 | CAS号153450-08-9 4H-1-Benzopyran... | CAS号94-09-7 对氨基苯甲酸乙酯

4-Acetylamino-Benzoic Acid Allyl Ester置于sodium Tetrahydroborate,盐酸,水体系中,用 二甲基亚砜 作为反应溶剂,化学反应 0.5H,以81%的收率获得产物对乙酰氨基苯甲酸
参考文献:利用 Dmso 中的 Nabh4 轻松且化学选择性地裂解烯丙基羧酸酯
标题:利用 Dmso 中的 Nabh4 轻松且化学选择性地裂解烯丙基羧酸酯
摘要:摘要 使用廉价的硼氢化钠试剂在二甲基亚砜 (Dmso) 中观测到了一种新的烯丙基羧酸酯脱保护方法.脂肪族和芳香族烯丙基羧酸酯顺利脱保护.烯丙酯基团可以比苯酚更好地选择性脱保护.
DOI:10.1080/00397910902963694

专利信息

专利号:US-10918627-B2
优先权日:2016-05-11
标 题:Convergent and enantioselective total synthesis of Communesin analogs
发明人：MOVASSAGHI MOHAMMAD; LATHROP STEPHEN PAUL; POMPEO MATTHEW W; CHANG WEN-TAU TIMOTHY
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:A highly convergent biomimetic synthesis of a complex polycyclic scaffold has been successfully implemented. From these efforts, compounds having a structure of Formula (I): n nor a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1 -R 8 and m, n, r, s, t, and u are as defined herein, is provided. Methods of making such compounds are also disclosed as are methods for the treatment of cancer, various infectious diseases, and abnormal cardiovascular function.

专利号:WO-2024104433-A9
优先权日:2022-11-16
标 题:Use of galectin-1 as immune checkpoint in preparation of tumor immunotherapy medicament and medicament
发明人：ZHANG YU; HONG YU; SI XIAOFANG; LIU WENJING; MAI XUEYING
权利人:NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING
摘要:Provided are use of galectin-1 (Gal-1) as an immune checkpoint in the preparation of a tumor immunotherapy medicament and the medicament, and provided is a new tumor immunotherapy strategy targeting the new immune checkpoint. Lactose and a derivative thereof can inhibit the immune checkpoint by competing Gal-1 on the surfaces of a cancer cell and an immune cell, and do not have significant toxic and side effects. Knocking out B4GATL1 to reduce protein galactosylation can significantly reduce the level of Gal-1 transferred from a tumor to a T cell, thereby enhancing the activation and function of the T cell. In addition, a lactose synthetase component LALBA is overexpressed in a mouse tumor, and de novo synthesis of lactose in a tumor microenvironment can be realized, such that an immune response mediated by a CD8+ T cell is enhanced. In combination with the anti-tumor effect and economic cost of lactose, a wide and feasible idea is provided for cancer treatment.

专利号:US-9388147-B2
优先权日:2009-11-13
标题 :Selective sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA; TIMONY GREGG ALAN; BROOKS JENNIFER L; PEACH ROBERT; SCOTT FIONA LORRAINE; HANSON MICHAEL ALLEN
权利人:RECEPTOS INC; CELGENE INTERNAT II SÃ?RL
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9394264-B2
优先权日:2009-11-13
标 题:Sphingosine 1 phosphate receptor modulators and methods of chiral synthesis
发明人：MARTINBOROUGH ESTHER; BOEHM MARCUS F; YEAGER ADAM RICHARD; TAMIYA JUNKO; HUANG LIMING; BRAHMACHARY ENUGURTHI; MOORJANI MANISHA
权利人:RECEPTOS INC
摘要:Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such compounds are provided. Uses, methods of treatment or prevention and methods of preparing inventive compositions including inventive compounds are provided in connection with the treatment or prevention of diseases, malconditions, and disorders for which modulation of the sphingosine 1 phosphate receptor is medically indicated.

专利号:US-9359327-B2
优先权日:2008-06-30
标题:Process for the preparation of substituted pyrimidine derivatives
发明人：CESCO-CANCIAN SERGIO; CHEN HONGFENG; GRIMM JEFFREY S; MANI NEELAKANDHA S; MAPES CHRISTOPHER M; PALMER DAVID C; PIPPEL DANIEL J; SORGI KIRK L; XIAO TONG
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H 4 receptor modulators, and to intermediates in H4 modulator synthesis.

专利号:US-10640508-B2
优先权日:2017-10-13
标 题 :Diazene directed modular synthesis of compounds with quaternary carbon centers
发明人：MOVASSAGHI MOHAMMAD; LINDOVSKA PETRA
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:Diazene-directed modular synthesis is described for the preparation Csp2-Csp3 and Csp3-Csp3 linkages where one or more stereogenic quaternary carbon centers are formed. The disclosed methods are directed to the preparation of compounds of Formula (I), or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, from compounds of Formula (II): n nwherein R 1 -R 5 and q are as defined independently for each occurrence herein. A wide variety of compounds can be accessed in this manner, including oligocyclotryptamines, where the stereochemistry of each subunit is beneficially secured before fragment coupling.