CAS: 52898-32-5; N-(3-Buten-1-yl)Phthalimide

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CAS号5162-44-7 4-溴-1-丁烯 | CAS号1074-82-4 邻苯二甲酰亚胺钾盐 | CAS号31645-84-8 2-(4-CHLORO-2-B... | CAS号627-27-0 3-丁烯-1-醇 | CAS号762-72-1 烯丙基三甲基硅烷 | CAS号616883-83-1 O-phthalimidome... | CAS号106-95-6 烯丙基溴 | CAS号3598-60-5 4-(1,3-二氧代异吲哚啉-... | CAS号3783-77-5 2-(3-氧代丁基)异吲哚啉-... | CAS号2524-49-4 3-丁烯-1-胺 | CAS号17875-18-2 3-丁烯胺盐酸盐 | CAS号2436-29-5 3-邻苯二甲酰亚胺丙醛 | CAS号86506-70-9 2-(2-(2-环氧乙烷基)乙... | CAS号93272-47-0 2-[3-hydroxy-4-...

3-丁烯-1-醇置于邻苯二甲酸亚胺,偶氮二甲酸二异丙酯,三苯基膦体系中,用 四氢呋喃 作为反应溶剂,化学反应 3.03H,以100%的收率获得产物n-(4-烯丁基)邻苯二甲酰亚胺
参考文献:通过级联氮杂-Prins反应合成氮杂双环:访问吲哚并立核苷和喹喔啉核
标题:通过级联氮杂-Prins反应合成氮杂双环:访问吲哚并立核苷和喹喔啉核
摘要:报道了从无环材料开始的分子内氮杂-Prins和氮杂-甲硅烷基-Prins反应的第一个详细研究.该方法允许快速灵活地访问[6,5]和[6,6]氮杂双环化合物的阵列,它们形成了各种生物碱的核心骨架.基于我们对氮杂-Prins和氮杂-甲硅烷基-Prins环化的研究结果,在此我们提出了使用一锅n级联反应工艺简单地制备吲哚并咪唑和喹喔啉的氮杂双环核分子的简单方法.-酰基亚胺离子形成,然后进行氮杂-Prins环化以及消除或碳正离子捕获.通过合理选择路易斯酸和一种或多种溶剂,可以在杂环中引入一系列不同的取代基,卤代,苯基和酰胺基取代的氮杂双环产物均可通过这些高度非对映选择性的方法获得.
DOI:10.1021/acs.Joc.5B01301

专利信息

专利号:US-11708320-B2
优先权日:2018-06-29
标 题:Environmentally-friendly hydroazidation of olefins
发明人：XU HAO
权利人:UNIV GEORGIA STATE RES FOUND
摘要:The present invention provides processes for the synthesis of organic azides, intermediates for the production thereof, and compositions related thereto.

专利号:US-6410526-B1
优先权日:1999-06-02
标题 :αv integrin receptor antagonists
发明人：DUGGAN MARK E; HARTMAN GEORGE D; MEISSNER ROBERT S; PERKINS JAMES J
权利人:MERCK & CO INC
摘要:The present invention relates to novel nonanoic acid derivatives, their synthesis, and their use as alphav integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors alphavbeta3 and alphavbeta5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

专利号:US-6472403-B2
优先权日:2000-01-20
标 题 :αV integrin receptor antagonists
发明人：DUGGAN MARK E; HALCZENKO WASYL; HUTCHINSON JOHN H; LI AIWEN; MEISSNER ROBERT S; PERKINS JAMES J; STEELE THOMAS G; WANG JIABING; PATANE MICHAEL A
权利人:MERCK & CO INC
摘要:The present invention relates to novel imidazolidinone derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

专利号:US-7109191-B2
优先权日:2001-05-03
标题 :Benzazepinone alpha vintegrin receptor antagonists
发明人：MEISSNER ROBERT S; COLEMAN PAUL J; DUGGAN MARK E; HARTMAN GEORGE D; WANG JIABING; HUTCHINSON JOHN H
权利人:MERCK & CO INC
摘要:The present invention relates to novel benzazepinone derivatives, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and αvβ5 and are therefore useful for inhibiting bone resorption, treating and/or preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.

专利号:US-7056909-B2
优先权日:2000-07-26
标题 :Alpha v integrin receptor antagonists
发明人：WANG JIABING
权利人:MERCK & CO INC
摘要:The present invention relates to novel chain-fluorinated alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, inflammatory arthritis, viral disease, cancer, and metastatic tumor growth.

专利号:US-7153862-B2
优先权日:2000-01-24
标 题 :αv integrin receptor antagonists
发明人：ASKEW BEN C; BRESLIN MICHAEL J; DUGGAN MARK E; HUTCHINSON JOHN H; MEISSNER ROBERT S; PERKINS JAMES J; STEELE THOMAS G; PATANE MICHAEL A
权利人:MERCK & CO INC
摘要:The present invention relates to novel alkanoic acid derivatives thereof, their synthesis, and their use as αv integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors αvβ3 and/or αvβ5 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammatory arthritis, cancer, and metastatic tumor growth.