CAS: 5192-23-4; 4-Aminoindole

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CAS号4769-97-5 4-硝基吲哚 | CAS号78283-21-3 3-nitro-trans-2... | CAS号7439-89-6 铁粉 | CAS号606-20-2 2,6-二硝基甲苯 | CAS号78283-23-5 1-hydroxy-4-nit... | CAS号52537-01-6 二氢吲哚-4-胺 | CAS号603-83-8 2-甲基-3-硝基苯胺 | CAS号4637-24-5 N,N-二甲基甲酰胺二甲基缩醛 | CAS号2942-36-1 5-Nitr°Cinnoline | CAS号4769-97-5 4-硝基吲哚 | CAS号135531-91-8 7-hydroxy-4-nit... | CAS号135531-89-4 5-hydroxy-4-nit... | CAS号84807-09-0 4-(1-哌嗪基)-1H-吲哚 | CAS号885270-30-4 1-B°C-4-氨基吲哚 | CAS号2380-94-1 4-羟基吲哚 | CAS号819850-13-0 (1H-吲哚-4-基)-氨基甲酸叔丁酯 | CAS号85696-93-1 N-methyl-1H-ind... | CAS号581812-74-0 4-Is°Cyanato-1H...

2,6-二硝基甲苯置于raney Ni (W-2) Palladium On Activated Charcoal,硫酸,氢气,四乙基对甲苯磺酸铵体系中,用 甲醇,N,N-二甲基甲酰胺,Xylene 作为反应溶剂,25.0~170.0 °C,911.92 Kpa 条件下,反应 29.83H,反应生成 4-氨基吲哚
参考文献:通过相应的二氢吲哚轻松合成 4-羟基和 4-氨基吲哚
标题:通过相应的二氢吲哚轻松合成 4-羟基和 4-氨基吲哚
摘要:2-(2,6-二氨基苯基)乙醇在70%磷酸水溶液中加热可转化为4-羟基二氢吲哚,在30%硫酸水溶液中加热可转化为4-氨基二氢吲哚.4-羟基-和4-氨基吲哚都是通过二氢吲哚在1,4-二甲基苯中在钯炭上回流脱氢得到的.
DOI:10.1246/bcsj.62.3742

专利信息

专利号:US-5256799-A
优先权日:1992-07-14
标 题 :Preparation of 6-hydroxyindolines and their use for preparation of novel laser dyes
发明人：FIELD GEORGE F; HAMMOND PETER R
权利人:US OF AMERICAS AS REPRESENTED
摘要:A novel method for the synthesis of 6-hydroxyindolines and new fluorescent dyes produced therefrom, which dyes are ring-constrained indoline-based rhodamine class dyes. These dyes have absorption and emission spectra which make them particularly useful in certain dye laser applications.

专利号:US-9533959-B2
优先权日:2013-10-07
标 题:Methods of regioselective synthesis of 2,4-disubstituted pyrimidines
发明人：CHARRIER JEAN-DAMIEN; O'DONNELL MICHAEL EDWARD
权利人:VERTEX PHARMA
摘要:The present invention relates to the novel regioselective syntheses of 2,4-disubstituted pyrimidines through sequential nucleophilic aromatic substitutions.

专利号:US-3901899-A
优先权日:1973-04-27
标题 :Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an Nhaloaniline with a Beta -carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the Beta carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an Alpha -ethyl- Beta -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:US-3992392-A
优先权日:1973-04-27
标题:Synthesis of indoles from anilines and intermediates therein
发明人：GASSMAN PAUL G
权利人:UNIV OHIO STATE RES FOUND
摘要:Preparing indoles and intermediates therefor by reacting an N-haloaniline with a β-carbonylic hydrocarbon sulfide to form an azasulfonium halide, reacting the azasulfonium halide with a strong base to form a thio-ether indole derivative, and then reducing the thio-ether indole, e.g. with Raney nickel, to form the indole compound. When an acetal or ketal of the β-carbonyl hydrocarbon sulfide is used, the azasulfonium salt is treated with a base, and then with an acid to form the thio-ether indole derivative. When an α-ethyl-β -carbonylic hydrocarbon sulfide is used, the resulting azosulfonium salt reacts with strong base to form a thio-ether indolenine derivative, which on reduction with Raney nickel or complex metal hydrides yields 3-substituted indoles. The aniline may be an aminopyridine to form an aza-indole compound in the process. The azasulfonium salts and thio-ether indole or thio-ether indolenine derivatives can be isolated and recovered from their respective reaction mixtures. The thio-ether-indole and thio-ether indolenine derivatives are useful as intermediates to make the indoles without the thio-ether group. The indoles are known compounds having a wide variety of uses, e.g., in making perfumes, dyes, amino acids, pharmaceuticals, agricultural chemicals and the like.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:CN-114315595-B
优先权日:2021-11-30
标题 :Preparation method of a carbon-supported iron-based catalyst and its application in the synthesis of anti-cancer inhibitor intermediates