CAS: 448235-52-7; L-Pyrrolysine

专利信息

专利号:US-2008287649-A1
优先权日:2006-12-29
标 题 :Methods for the synthesis of cyclic peptides
发明人：CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; HAN YEUN-KWEI; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of cyclic peptides are provided, as well as novel dipeptide compounds. The methods include the solid phase synthesis of a dipeptide, which is the coupled to a second peptide in a solid phase reaction. The peptide is then cyclized following the coupling reaction. The methods and dipeptides are particularly useful for the synthesis of MC-4 receptor agonist peptides.

专利号:US-2007179279-A1
优先权日:2005-12-30
标题:Methods for the synthesis of arginine-containing peptides
发明人：CHEN LIN; ROBERTS CHRISTOPHER R
权利人:CHEN LIN; ROBERTS CHRISTOPHER R
摘要:Methods for the synthesis of arginine-containing peptides are provided. The methods include a step that minimizes contact of side chain protected arginine with base prior to the coupling step.

专利号:US-11964965-B2
优先权日:2020-05-08
标题 :Methods of manufacture and synthesis of fluorescent dye compounds and uses thereof
发明人：KULARATNE SUMITH A; GAGARE PRAVIN
权利人:ON TARGET LABORATORIES LLC
摘要:The present disclosure relates to synthesizing and utilizing fluorescent dye compounds or pharmaceutically acceptable salts thereof. Conjugation of amino acid groups to the fluorescent dyes increase specificity and detection of the compound. Methods of manufacture and synthesis of the compounds for use thereof in diagnostic imaging are contemplated.

专利号:WO-2025075817-A1
优先权日:2023-10-02
标 题 :Methods for synthesis of protein hetero-polymers
发明人：SHRADER ALANNA SCHEPARTZ; ROE LEAH TANG
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of protein hetero-polymers uses an intramolecular Backbone Extension Acyl Rearrangement (BEAR) reactions to orthogonally and site-specifically embed a β-, γ- or δ-amino acid residue into proteins.

专利号:US-9255255-B2
优先权日:2013-03-04
标 题 :Synthesis of linear and branched polymers of polypeptides through direct conjugation
发明人：ALBAYRAK CEM; SWARTZ JAMES R; LU YUAN
权利人:UNIV LELAND STANFORD JUNIOR
摘要:Methods are provided for a one step synthesis of polypeptide polymers or co-polymers. The polymers or co-polymers can be linear or branched. In the methods of the invention, the coding sequence for the polypeptide(s) to be polymerized is altered by introducing one or more codons for an nonnatural amino acid, which coding sequence is then utilized to produce the cognate polypeptide. The nonnatural amino acids are selected to be reactive with each other in a bioorthogonal reaction, and are combined in a conjugation reaction with the desired components of the polymer.

专利号:US-10427126-B2
优先权日:2015-10-28
标题 :System and method for longitudinal analysis of peptide synthesis
发明人：Bannen Ryan; Barilovits Sarah; PATEL JIGAR; SULLIVAN ERIC; TAN JOHN
权利人:ROCHE SEQUENCING SOLUTIONS INC
摘要:The present invention provides a system and method for assessing a synthetic peptide population including interrogating a population of peptide features in the presence of a receptor having an affinity for a binder sequence. The population of peptide features is synthesized over a plurality of synthesis periods and includes a plurality of control peptide features synthesized to have an amino acid sequence including the binder sequence. The control peptide features include a first feature synthesized beginning with a first one of the synthesis periods, and a second feature synthesized beginning after the first one of the synthesis periods such that synthesis of the second control peptide feature is delayed by at least one synthesis period. The method further includes detecting a signal output characteristic of an interaction of the receptor with the control peptide features, the signal output indicative of the fidelity of synthesis of the population of peptide features.