CAS: 431058-46-7; Ethyl (S)-10-Fluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylate

英文名称Ethyl (S)-10-Fluoro-3-Methyl-7-Oxo-2,3-Dihydro-7H-[1,4]Oxazino[2,3,4-Ij]Quinoline-6-Carboxylate
中文名称(S)-10-氟-3-甲基-7-氧代-2,3-二氢-7H-[1,4]噁嗪并[2,3,4-ij]喹啉-6-羧酸乙酯
CAS编号431058-46-7
MFCD编号:MFCD32644292
分子式:C15H14FNO4分子量:291.27
产品CID: 1442778
产品分类有机原料→分子砌块→芳杂环类化合物→喹啉类化合物

相似结构搜索
InChIKey: ARBUBLJBNIYBJU-QMMMGPOBSA-N
1S/C15H14FNO4/c1-3-20-15(19)10-6-17-8(2)7-21-14-11(16)5-4-9(12(14)17)13(10)18/h4-6,8H,3,7H2,1-2H3/t8-/m0/s1
计算化学: 氢键受体数5.0氢键供体数*可旋转键数2.0

相似化合物

106939-34-8 100986-89-8 100986-89-8

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
安全声明H303+H313+H333

上下游产品

(Z)-3-((S)-2-Hydroxy-1-methyl-ethylamino)-2-(2,3,4-trifluoro-benzoyl)-acrylic acid ethyl ester 2,3,4-trifluoro-benzoyl chloride ethyl 3-(2,3,4-trifluorophenyl)-3-oxopropanoateH-1-oxa-3a-aza-phenalene-5-carboxylic acid9-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acid levofloxacin

合成工艺路线路线简述

📜2,3,4-三氟苯甲酰氯置于正丁基锂,乙酸酐,Sodium Hydride体系中,用四氢呋喃作为反应溶剂,化学反应生成左氧氟沙星杂质i
参考文献:Synthesis And Biological Testing Of Non-Fluorinated Analogues Of Levofloxacin
标题:Synthesis And Biological Testing Of Non-Fluorinated Analogues Of Levofloxacin
摘要:Quinolones Without The Usual 6-Fluorine Substituent Have Been Recently Described As Potent Antibacterial Agents. A Series Of Non-Fluorinated Analogues Of The Antibacterial Quinolone Levofloxacin Were Synthesized And Tested. (C) 2003 Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0960-894X(03)00399-8