CAS: 4214-72-6; N-Isopropylpyrimidin-2-Amine
该化合物是一种多用途有机化合物,其火药环被丙基组替代,在有机合成方面,特别是在形成矿衍生物方面,具有重大优势,其结构多样性使得各种药用活性化合物得以合成,其处理和净化的便利性使它成为化学研究中有价值的中间体.
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;;; - InChIKey: FTCYIGBVOHNHCD-UHFFFAOYSA-N
- InChI=1S/C7H11N3/c1-6(2)10-7-8-4-3-5-9-7/h3-6H,1-2H3,(H,8,9,10)
- 计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数2.0
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77476-95-0 931-61-3 1249988-96-2物理性质
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CAS号1722-12-9 2-氯嘧啶 | CAS号75-31-0 异丙胺 | CAS号2016-57-1 正癸胺合成工艺路线路线简述
- 合成目标产物 2-Pyrimidinamine, N-(1-Methylethyl)- (9CI) 主要起始原料 2-Chloropyrimidine And Decylamine
- (文献来源)合成步骤主要原料 2-Chloropyrimidine 和 Decylamine
📜2-氯嘧啶,异丙胺 以 乙醇 作为反应溶剂,化学反应 18.0H,以80%的收率获得产物伊沙索宁
参考文献:N-乙基,N-异丙基和n-叔丁基取代的2-氨基吡嗪和2-氨基嘧啶的气相热解反应
标题:N-乙基,N-异丙基和n-叔丁基取代的2-氨基吡嗪和2-氨基嘧啶的气相热解反应
摘要:N-乙基(1),N-异丙基(2),N-叔丁基(3)取代的2-氨基吡嗪和n-乙基(4),N-异丙基(5)和nt-的气相消除速率丁基 (6) 取代的 2-氨基嘧啶已被测量.这些化合物经历单分子一级热解反应.在 600 K 时,吡嗪类和嘧啶类的伯,仲,叔烷基同系物的相对比率分别为 1:14.4:38.0 和 1:20.8:162.5.这些化合物的反应性已与烷氧基类似物的反应性以及彼此进行了比较.产品分析与动力学数据一起用于勾勒出研究中化合物消除反应的可行途径.© 2000 John Wiley & Sons,Inc. Int J Chem Kinet 32: 403-407,2000
DOI:10.1002/(Sici)1097-4601(2000)32:7<403::Aid-Kin2>3.0.Co;2-P
海关参考信息
- 2921199090-其他无环单胺
- 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-4266058-A
优先权日:1979-07-04
标 题:Synthesis of 2-isopropylamino-pyrimidine
发明人：DEMOSTHENE CLAUDE G; ASPISI CHRISTIAN R
权利人:SOC D ETUDES PROD CHIMIQUE
摘要:The present invention provides a process for the synthesis of 2-isopropylamino-pyrimidine by aminolysis of 2-methylsulphonyl-pyrimidine using isopropylamine. The aminolysis is effected, according to the present invention, by refluxing isopropylamine and 2-methylsulphonyl-pyrimidine in the absence of a solvent. Using this technique, the 2-isopropylamino-pyrimidine has been obtained in a substantially quantitative yield.
专利号:US-9550000-B2
优先权日:2011-09-09
标题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：ROBINSON SIMON P; YU MING
权利人:ROBINSON SIMON P; YU MING; LANTHEUS MEDICAL IMAGING INC
摘要:The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, the imaging agent is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. In some embodiments, methods and compositions for assessing perfusion and innervation mismatch in a portion of a subject are provided.
专利号:OA-06607-A
优先权日:1979-07-04
标题 :Synthesis of 2-isopropylamino pyrimidine.
专利号:IL-60234-A0
优先权日:1979-07-04
标题:Synthesis of 2-isopropylamino-pyrimidine
专利号:DE-3025419-C2
优先权日:1979-07-04
标 题:Process for the synthesis of 2-isopropylaminopyrimidine
专利号:LU-82517-A1
优先权日:1979-07-04
标 题:SYNTHESIS OF ISOPROPYLAMINO-2 PYRIMIDINE
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主要参考文献
1. Heckmatt JZ, Hyde SA, Gabain A, Dubowitz V. Therapeutic trial of isaxonine in Duchenne muscular dystrophy. Muscle Nerve. 1988 Aug;11(8):836-47. doi: 10.1002/mus.880110807. 72(4):406-8. doi: 10.1007/BF00687274.合成参考文献
摘要:D.J. Brown and J.S. Harper. J. Chem. Soc. 1965, 5542.
参考文献:10.1136/jnnp.48.9.933
摘要:Le Quesne PM, Fowler CJ, Harding AE. A study of the effects of isaxonine on vincristine-induced peripheral neuropathy in man and regeneration following peripheral nerve crush in the rat. Journal of Neurology, Neurosurgery & Psychiatry. 1985 Sep 01;48(9):933–5. doi: 10.1136/jnnp.48.9.933.
参考文献:10.1136/jnnp.48.12.1193
摘要:Hallett M, Tandon D, Berardelli A. Treatment of peripheral neuropathies. Journal of Neurology, Neurosurgery & Psychiatry. 1985 Dec 01;48(12):1193–207. doi: 10.1136/jnnp.48.12.1193.
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