CAS: 28708-32-9; (3R,4R,5R)-5-(Acetoxymethyl)Tetrahydrofuran-2,3,4-Triyl Triacetate

相似化合物

13035-61-5 144490-03-9 176299-71-1

上下游产品

L-(+)-arabinose acetic anhydride L-arabinose methyl 2,3,6-tri-O-acetyl-5-deoxy-L-arabino-hexofuranoside4'-methoxyphenyl α-L-arabinofuranoside Acetic acid (2R,3R,4S,5S)-4-acetoxy-5-acetoxymethyl-2-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(4-methoxy-phenoxy)-tetrahydro-furan-2-ylmethoxy]-tetrahydro-furan-3-yl ester Acetic acid (2S,3S,4R,5S)-4-acetoxy-2-((2R,3R,4S,5S)-3,4-diacetoxy-5-acetoxymethyl-tetrahydro-furan-2-yloxymethyl)-5-(4-methoxy-phenoxy)-tetrahydro-furan-3-yl ester methyl 2,3,4-tri-O-benzoyl-6-S-(2,3,5-tri-O-acetyl-α-L-arabinofuranosyl)-6-thio-α-D-galactoyranoside

📜D-核糖,乙酸酐置于吡啶体系中,用 二氯甲烷 用作溶剂,化学反应 12.0H,反应生成四乙酰核糖
参考文献:钯在室温下使用糖和戊二烯鎓盐催化钯催化立体合成c-芳基糖苷† ‡
标题:钯在室温下使用糖和戊二烯鎓盐催化钯催化立体合成c-芳基糖苷† ‡
摘要:芳基的立体控制合成ç使用烯糖和芳基重氮盐在乙酸钯的存在下达到-Glycosides.宽范围的烯糖,包括d-Glucal,D-Galactal,大号-Rhamnal,D-Xylal和d-Ribal后行ç-Arylation在不同的芳基重氮四氟硼酸盐的存在下异头碳,并给合成有用2,3-脱氧3-酮-α-芳基-C ^-Glycosides以非常好至优异的产量.广泛的底物范围,简单的操作和室温反应使该方案在有机合成中非常有吸引力.
Doi:10.1039/c8Ob01393D

专利信息

专利号:US-9266863-B2
优先权日:2010-03-30
标题 :Process for the synthesis of azacitidine and decitabine
发明人：DE FERRA LORENZO; ZENONI MAURIZIO; TURCHETTA STEFANO; ANIBALDI MAURO; AMMIRATI ETTORE; BRANDI PAOLO; BERARDI GIORGIO
权利人:DE FERRA LORENZO; ZENONI MAURIZIO; TURCHETTA STEFANO; ANIBALDI MAURO; AMMIRATI ETTORE; BRANDI PAOLO; BERARDI GIORGIO; CHEMI SPA
摘要:Described herein is a process for the synthesis of azacitidine or decitabine, comprising the silylation of azacytosine in the presence of N,O-bis-trimethylsilyl-trifluoroacetamide. Such reaction is performed in an organic solvent, preferably aprotic, even more preferably selected from among dichloromethane, dichloroethane and/or acetonitrile. According to a further aspect of the process, 2 to 3 moles of N,O-bis-trimethylsilyl-trifluoroacetamide are used per mole of azacytosine, preferably from 2.2 to 2.5.

专利号:US-11629163-B2
优先权日:2017-06-30
标题:Methods of synthesizing nicotinamide riboside
发明人：MARCOTULLI ERIC; ALMINANA DAN; DELLINGER RYAN; MORRIS MARK; THAMATAM RAJESH
权利人:ELYSIUM HEALTH INC
摘要:Provided herein are efficient and scalable methods for the synthesis of nicotinamide riboside from riboside triacetate. Also provided are compositions comprising nicotinamide riboside, and therapeutic methods employing nicotinamide riboside.

专利号:US-4914233-A
优先权日:1988-03-01
标题:Synthesis of beta-thymidine
发明人：FRESKOS JOHN N; SENARATNE K PUSHPANANDA A
权利人:ETHYL CORP
摘要:A process is provided in which a mixture of alpha- and beta-anomers is converted selectively to the desired beta-thymidine. The process involves the following steps: (a) converting a mixture of alpha- and beta-anomers of tetra-O-acylribofuranose to tri-O-acyl-β-ribothymidine; (b) converting tri-O-acyl-β-ribothymidine to β-ribothymidine; (c) converting β-ribothymidine to 2,2'-anhydro-β-thymidine; (d) converting 2,2'-anhydro-β-thymidine to 2'-halo-2'-deoxy-5-methyluridine; and (e) converting 2'-halo-2'-deoxy-5-methyluridine to beta-thymidine. The mixture of alpha- and beta-anomers of tetra-O-acylribofuranose may be produced by any suitable procedure such as by converting lower alkyl ribofuranoside to the tetra-O-acylribofuranose mixture. The lower alkyl ribofuranosides may in turn be produced by various methods. However, a desirable way of effecting this conversion involves use of D-ribose as the starting material which is converted to the lower alkyl ribofuranoside.

专利号:US-2004186283-A1
优先权日:2003-03-17
标题:Synthesis of 5-azacytidine

专利号:US-7399754-B2
优先权日:2005-06-16
标 题:N2-quinoline or isoquinoline substituted purine derivatives
发明人：WU ZHANGGUI
权利人:WU ZHANGGUI
摘要:Novel compound having the following formula: n nwherein W represents a hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted C 3-6 cycloalkyl, or an optionally substituted C 1-6 haloalkyl, Y represents a hydrogen, or a saccharide, Q represents a quinoline or isoquinoline. Also disclosed are a pharmaceutical compositions comprising the same, methods for treating cancer using the same, and methods for the synthesis of the same.

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides