CAS: 23583-21-3; Ethyl 3-(Benzylamino)Propanoate

该化合物是一种合成有机化合物,主要用作制药和浸泡物合成的中间体,其结构上有一个苯基保护的矿物质组和一个乙酯酸性组,在各种化学变异中提高溶性性和反应性;该化合物在标准条件下具有稳定性,并与一系列混合试剂相兼容,适合沉淀物的形成;其多功能性允许用于编写β-氨酸衍生物和经修改的peptides;乙基酯组有利于进一步的功能化,而在温和条件下可以有选择地取消苯基保护,在合成路线上具有灵活性.

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合成工艺路线路线简述

    📜在 Sodium Tetrahydroborate,盐酸体系中,用 乙醇 用作溶剂,化学反应生成3-(苄基氨基)丙酸乙酯
    参考文献:Wrinkle-Improving Agent
    标题:Wrinkle-Improving Agent
    摘要:该发明提供了一种新型的改善皱纹的剂,具有改善皱纹的效果,即使应用于皮肤也不会带来安全或疼痛问题,并且包含一种非常安全的物质作为活性成分.发现n-苯甲酰-β-丙氨酸,其他特定的β-丙氨酸衍生物及其盐具有改善皱纹的效果,因此开发了一种改善皱纹的剂,其活性成分包含从这些特定的β-丙氨酸衍生物及其盐组成的群体中选择的一种,两种或更多种化合物.

    海关参考信息

    专利信息


    专利号:CN-114369052-B
    优先权日:2021-12-21
    标题 :A kind of synthesis method of 3-aminopyrrolidine dihydrochloride

    专利号:US-4604397-A
    优先权日:1984-05-10
    标题:Certain benzo-(pyrano and thiopyrano)-pyridines, useful as CNS agents
    发明人:HUTCHISON ALAN J
    权利人:CIBA GEIGY CORP
    摘要:Disclosed are the compounds of formula I ##STR1## wherein X represents oxygen or sulfur; ring A is unsubstituted or substituted by one to three identical or different substituents selected from hydroxy, hydroxy-lower alkyl, etherified hydroxy, etherified hydroxy-lower alkyl, acyloxy, acyloxy-lower alkyl, halogen, lower alkyl, trifluoromethyl, amino, mono- and di-lower alkylamino and acylamino; or ring A is substituted by one lower alkylenedioxy; R represents hydrogen, lower alkyl or aryl-lower alkyl; R 1 represents hydrogen, lower alkyl, lower alkylthio-lower alkyl, amino, acylamino, (amino, mono- or di-lower alkylamino)-lower alkyl, carboxy, lower alkoxycarbonyl, carbamoyl or mono- or di-lower alkylcarbamoyl; R 2 to R 5 represent hydrogen or lower alkyl; the dehydro derivatives thereof with a double bond at the 1,2-position, or at the 1,10b-position in which case R 5 is absent; or a pharmaceutically acceptable salt thereof; methods for their synthesis; pharmaceutical compositions thereof; and use thereof as psychactive agents for the treatment of central nervous system disorders.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1021/acs.jmedchem.2c01165
    摘要:Barthel T, Wollenhaupt J, Lima GMA, Wahl MC, Weiss MS. Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites. J Med Chem. 2022 Nov 10;65(21):14630–41. doi: 10.1021/acs.jmedchem.2c01165.
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