CAS: 22414-26-2; 2-Phenylpropanoyl Chloride

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hydratropic acid (RS)-2-phenyl-1-propanol fraeseol 2-Phenylpropanal 2-phenyl-propionic acid 2,2'-piperazine-1,4-diyl-diethyl ester (E)-1-chloro-3-phenylbutan-2-one rac-1-(4-methylphenyl)-2-phenylpropan-1-one 3-phenyl-butan-2-one

杨梅醛置于氯化亚砜,Permanganate(Vii) Ion体系中,化学反应生成2-苯基丙酰氯
参考文献:酮亚胺的快速酸催化和非催化水合
标题:酮亚胺的快速酸催化和非催化水合
摘要:在ph范围为2-13的水中(μ1.0; 25°)中,已经检查了一系列酮亚胺(9)的水合速率.注意到了三种水合成酰胺的机理(8):(a)在2-7的ph范围内,从h 3 O +进行质子转移,产生一般的酸催化作用(给出k H 3 O + / K D 3 O + 2.65);(b)在ph＞ 7(其中k H 2 O + / K D 2 O += 4.8)下由h 2 O进行的一般酸催化作用;(c)确定ho-攻击的速率.最后一种机制仅显示为n-芳基酮亚胺,例如(9E);其他n-烷基酮亚胺继续通过速率决定质子从水的反应进行反应,即使在ph 13时也是如此.当(9A)在酸性或碱性d 2 O中反应时,仅掺入一个氘,而氘代的酮亚胺(9F )仅掺入一个氘就证实了这一结果.)不会在水中反应时使标签松动.对于涉及从h 3 O +或h 2转移h +的反应,取代基的作用是平行的o; 在改变碳(质子化位点)上的取代基方面
Doi:10.1039/p29800000579

专利信息

专利号:US-3959322-A
优先权日:1960-09-22
标 题:Synthesis of 13-alkyl-gon-4-ones
发明人：HUGHES GORDON ALAN; SMITH HERCHEL
权利人:SMITH HERCHEL
摘要:The preparation of 13-methylgon-4-enes and novel 13-polycarbonalkylgon-4-enes by a new total synthesis is described. 13-Alkylgon-4-enes having progestational, anabolic and androgenic activities are prepared by forming a tetracylic gonane structure unsaturated in the 1,3,5(10),9(11) and 14-positions, selectively reducing in the B- and C-rings, and converting the aromatic A-ring compounds so-produced to gon-4-enes by Birch reduction and hydrolysis.

专利号:US-2005009924-A1
优先权日:2003-07-08
标 题 :Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives
发明人：HUANG HSU-SHAN
摘要:This invention relates to novel anthraquinone compounds useful in the treatment of allergic, inflammatory conditions, antioxidant, tumor condition, stem cell application, tissue engineering, applied in treating age-associate tissue degeneration, reverse organ failure in chronic high-turnover disease and therapeutic compositions containing such compounds. The compounds of the present invention are 1,4-, 1,5- and 1,8-difunctionalized anthraquinones or analogs thereof. According to the practice of the invention, there are provided bis-symmetrical substituted anthraquinone compounds according to formula I: n n nwherein R1, R2, R3 and R4 present a straight, aminoalkylamino side chains or branched chain alkyl group having 1 to 6 carbons which may be substituted with one or more groups of R5, or R1, R2, R3 and R4 present phenyl or benzyl which may be substituted with one or two groups of R6; wherein R5 is selected from the group consisting of halogen, —RNH 2 , —RNH 2 R, —ROH, —NO 2 , —OCH 3 , —OCH 2 CH 3 , and —OCH 2 CH 2 CH 3 ; and wherein R6 is selected from the group consisting of a straight or branched chain alkyl group having 1 to 4 carbons, halogen, —RNH 2 , —RNH 2 R, —ROH, —NO 2 , —OCH 3 , —OCH 2 CH 3 , —OCH 2 CH 2 CH 3 , —CH 2 Br, —CH 2 Cl, —CH 2 OH, —C(CH 3 ) 3 , —(CH 2 ) 2 0H, —(CH 2 ) 3 OH, —(CH 2 ) 4 OH, —CH 2 NH 2 , —(CH 2 ) 2 NH 2 , —(CH 2 ) 3 NH 2 , —(CH 2 ) 4 NH 2 , —(CH 2 ) 5 NH 2 , —CH 2 N(CH 3 ) 2 , —(CH 2 ) 2 N(CH 3 ) 2 , —(CH 2 ) 2 NH(CH 2 ) 2 OH, —(CH 2 ) 3 NH(CH 2 ) 2 OH, —(CH 2 ) 2 NHCH 2 OH, —(CH 2 ) 3 NHCH 2 OH, —CH 2 CH(CH 3 ) 2 , —CHCl 2 , —CH(CH 3 )Cl, —(CH 2 ) 2 Cl, —(CH 2 ) 3 Cl, —(CH 2 ) 3 Br, —(CH 2 ) 4 Br, and —(CH 2 ) 4 Cl. n n Chart 1. Activation of hTERT promoter-driven SEAP expression by c-Myc. About 1×10 7 hTERT-BJ1 cells were transfected with 13.5 μg each of plasmid pSEAP or pPhTERT-SEAP and of plasmid pMT2T or pMT2T-cMyc by electroporation. After 24 h, viable cells were harvested, and reinoculated at a density of 3×10 5 /mL, and the SEAP activity after 24 h at 37 â–¡. The transfection efficiency of each experiment was determined by cotransfection with 1.5 μg of plasmid pCMVβ. The values were determined from three experiments. P<0.05 is presented by an asterisk.

专利号:WO-9118890-A1
优先权日:1990-06-07
标 题:Bicyclic chiral compounds
发明人：BANKS MALCOLM ROBERT; CADOGAN JOHN IVAN GEORGE; DAWSON IAN MICHAEL; GOSNEY IAN; HODGSON PHILIP KENNETH GORDON
权利人:BRITISH PETROLEUM CO PLC
摘要:A compound of general formula I(a) and/or I(b) and/or I(c), in which R1 represents a methyl group or a group of the general formula -CH¿2?.SO2.R?2¿ or -CH¿2?.SO2.NR?2R3¿, in which each of R?2 and R3¿ independently represents an alkyl, cycloalkyl or optionally substituted phenyl or phenalkyl group; each of R?4, R5 and R6¿ independently represents a hydrogen atom or a methyl group; X represents a group of formula C(CH¿3?)2 or, when both of R?5 and R6¿ represent methyl groups, also represents a group of formula CH¿2?; Q represents an oxygen or sulphur atom; and Y represents a hydrogen atom, an alkali metal atom or a group of the general formula -COA in which A represents a halogen atom or an alkyl or alkoxy group optionally substituted by a phenyl, cycloalkyl, alkoxy or alkylcarbonyl group. The compounds are bicyclic optically active compounds and are useful in the synthesis of optical isomers and separation of optical isomers from mixtures.

专利号:US-4086423-A
优先权日:1973-10-12
标题 :Process for cephem synthesis
发明人：FIRESTONE RAYMOND A; RATCLIFFE RONALD W; CHRISTENSEN BURTON G
权利人:MERCK & CO INC
摘要:Cephalosporin antibiotics of the formula: ##STR1## are produced by cycloaddition of a glycine derivative of the formula ##STR2## with a thiazine derivative of the formula ##STR3##

专利号:EP-0824512-B1
优先权日:1995-05-12
标 题 :Synthesis of optically active aminoindanol

专利号:EP-0824512-A1
优先权日:1995-05-12
标题 :Synthesis of optically active aminoindanol