CAS: 209747-04-6; Tolterodine Impurity 13
该化合物是一种化学化合物,属于以多种生物活动而闻名的菜类,这种化合物具有苯丙胺结构的特征,其特点是有苯乙烯和皮兰环的引信,包括氢氧基(-OH)和甲基(-CH3)组,有助于其再活性和潜在药理特性;该苯组的存在增强了其芳香特性,可影响其在生物系统中的相互作用;这种性质的化合物通常表现出抗氧化剂,抗炎和潜在的抗癌活动,使其对药化学感兴趣;分子结构允许各种替代模式,可能影响溶性,稳定性和生物活性;与许多有机化合物一样,熔点,沸点和溶性等物理特性可以因物质的具体条件和纯度而变化;在与任何化学物质一起使用该化合物时,应当考虑安全数据及处理预防措施.
- 英文名称Tolterodine Impurity 13
- 中文名称6-甲基-4-苯基色满-2-醇
- IUPAC名称6-methyl-4-phenylchroman-2-ol
- 其它别名Rac-6-Methyl-4-Phenyl-2-Chromanol (Tolterodine Impurity); 6-Methyl-4-Phenyl-3,4-Dihydro-2H-Chromen-2-Ol; Tolterodine Lactol Impurity (Usp); Tolterodine Lactol Impurity; 2H-1-Benzopyran-2-Ol, 3,4-Dihydro-6-Methyl-4-Phenyl-; Rac-6-Methyl-4-Phenyl-2-Chromanol; 6-Methyl-4-Phenylchroman-2 - Alcohol; 6-Methyl-4-Phenylchroman-2-Ol
- CAS编号209747-04-6
- MFCD编号:MFCD23104241
- FDA UNII编号:K8U68SF3V5
- 分子式:C16H16O2分子量:240.3
- 产品CID: 1076378
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡喃类化合物
相似化合物
40546-94-9 959624-24-9 828933-86-4物理性质
上下游产品
1,4-bis-(6-methyl-4-phenyl-chroman-2-yl)-piperazine (E)-3-phenylpropenal p-cresol 6-methyl-4-phenyl-3,4-dihydr°CoumarinN,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 4-methyl-2-(1-phenyl-3-pyrrolidine-1-ylpropyl)phenol合成工艺路线路线简述
📜6-甲基-4-苯基色满-2-酮置于二异丁基氢化铝体系中,用 正己烷,甲苯 用作溶剂,化学反应 2.5H,以66%的收率获得外消旋-6-甲基-4-苯基-2-色满醇
参考文献:Hydrolase-Mediated Resolution Of The Hemiacetal In 2-Chromanols: The Impact Of Remote Substitution
标题:Hydrolase-Mediated Resolution Of The Hemiacetal In 2-Chromanols: The Impact Of Remote Substitution
摘要:Hydrolase-Catalysed Dynamic Kinetic Resolutions Of Chroman-2-Ol And 3-Methyl Chroman-2-Ol Can Be Effected With Up To 88% Conversion And 92% Ee Through The Use Of Organic Solvents. Extension To The Resolution Of The Tolterodine Precursor 1 Proved More Challenging. The Presence Of The Remote Phenyl Substituent Had A Significant Impact On The Resolution And It Was Not Possible To Achieve High Enantioselectivity Together With Efficient Conversion From The Focussed Panel Of Enzymes Screened. (C) 2017 Published By Elsevier Ltd.
Doi:10.1016/j.Tetasy.2017.04.001
海关参考信息
- 2902600000-乙苯
2905121000-正丙醇
2907121100-间甲酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-2007010691-A1
优先权日:2003-07-02
标 题:Enantioselective synthesis of enantiomerically enriched compounds
发明人：PICCOLO ORESS; ULGHERI FAUSTA; MARCHETTI MAURO
权利人:CONSIGLIO NAZIONALE RICERCHE
摘要:Method of preparing an enantiomerically enriched compound of formula (II) comprising enantioselective hydrogenation of a compound of general formula (I): where W, X and Z have the meanings indicated in the description, to give a compound of general formula (II): where W, Y, T and C* have the meanings indicated in the description, in the presence of a catalyst or its suitable precursor based on Rh, Ru or Ir, having an oxidation state of 0, +1 or +2, and containing at least one enantiomerically enriched chiral ligand.
专利号:US-7119212-B2
优先权日:2004-03-30
标 题 :Process for the preparation of tolterodine and intermediates thereof
发明人：COLOMBO LINO; ROSSI ROBERTO; ALLEGRINI PIETRO; CASTALDI GRAZIANO
权利人:DIPHARMA SPA
摘要:A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
专利号:WO-2005005356-A2
优先权日:2003-07-02
标 题 :Enantioselective synthesis of enantiomerically enriched compounds
专利号:EP-1644311-A2
优先权日:2003-07-02
标题:Enantioselective synthesis of enantiomerically enriched compounds
专利号:CN-103044274-A
优先权日:2012-11-29
标题:A kind of method of solvent-free synthesis tolterodine tartrate
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📌 第三方产品分析报告
合成参考文献
合成方法参考DOI号:10.1016/j.tetasy.2017.04.001
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