CAS: 201855-60-9; ((3S,4R)-1-Benzyl-4-(4-Fluorophenyl)Piperidin-3-yl)Methanol
- 英文名称((3S,4R)-1-Benzyl-4-(4-Fluorophenyl)Piperidin-3-yl)Methanol
- 中文名称[(3S,4R)-1-苄基-4-(4-氟苯基)-3-哌啶基]甲醇
- IUPAC名称((3S,4R)-1-benzyl-4-(4-fluorophenyl)piperidin-3-yl)methanol
- 其它别名(-)-(3S,4R)-4-(4-Fluorophenyl)-1-(Phenylmethyl)-3-Piperidinemethanol; (-)-Trans-1-Benzyl-4-(4-Fluorophenyl)-3-Hydroxymethylpiperidine; (3S,4R)-4-(4-Fluorophenyl)-1-(Phenylmethyl)- 3-Piperidinemethanol; Paroxetine Anhydrous Ep Impurity H; Paroxetine Impurity 22(Paroxetine Hcl Anhydrous Ep Impurity H); Paroxetine Impurity 1/paroxetine Ep Impurity H/[(3S,4R)-1-Benzyl-4-(4-Fluorophenyl)Piperidin-3-Yl]Methanol
- CAS编号201855-60-9
- MFCD编号:MFCD18252435
- 分子式:C19H22FNO分子量:299.39
- 产品CID: 1025228
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
上下游产品
isobutyl (3S,4R)-1-benzyl-4-(4-fluorophenyl)piperidine-3-carboxylate (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2,6-dioxopiperidine-3-carboxylic acid methyl ester (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester malonic acid dibenzyl esterMethanesulfonic acid (3S,4R)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ylmethyl ester paroxetine (3S,4R)-1-benzyl-4-(4-fluorophenyl)-3-[3,4-(methylenedioxy)-phenoxymethyl]piperidine合成工艺路线路线简述
📜对氟肉桂醛置于dimethyl Sulfide Borane,Platinum On Carbon,氢气,溶剂黄146体系中,用 2-甲基四氢呋喃 用作溶剂,60.0~100.0 °C,1.0 Mpa 条件下,反应 8.67H,反应生成[(3S,4R)-1-苄基-4-(4-氟苯基)-3-哌啶基]甲醇
参考文献:(-)-帕罗西汀的手性关键中间体的多克级流式合成,可通过无溶剂的非均相有机催化实现.
标题:(-)-帕罗西汀的手性关键中间体的多克级流式合成,可通过无溶剂的非均相有机催化实现.
摘要:抗抑郁药(-)-帕罗西汀的手性关键中间体的催化对映选择性合成已证明是连续克级的连续流动过程.关键步骤是添加无溶剂的有机催化共轭物,然后进行伸缩的还原胺化-内酰胺化-酰胺/酯还原顺序.由于采用了高效的非均相催化剂,并且采用了无溶剂或高度浓缩的条件,因此与以前的分批方法相比,流动法在生产率和可持续性方面提供了重要的进步.
Doi:10.1039/c9Sc04752B
海关参考信息
- 2902600000-乙苯
2902700000-异丙基苯
2905121000-正丙醇
2905141000-异丁醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
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主要参考文献
参考标题:Concise Synthesis Of Trans- And Cis-3,4-Disubstituted Piperidines Based On Regio- And Stereoselective Allylation Of Cyclopentenyl Esters作者:Junji Igarashi,Hiroyuki Ishiwata,Yuichi Kobayashi |发布日期:2004.10
摘要:3,4-Disubstituted Piperidines Were Synthesized Through Anti Sn2′ Allylation Of 4-Substituted 2-Cyclopentenyl Esters With Reagents Based On Rmgx And Cux, Thus Allowing Equal Access To Both Trans- And Cis-Isomers. As An Application, The Paroxetine Intermediate Was Synthesized Efficiently. During The Investigation, The Meoch2Co2 Group Was Found To Show High Reactivity In The Pivotal Anti Sn2′ Type Reaction
合成参考文献
合成方法参考DOI号:10.1016/S0040-4039(01)01096-6
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