CAS: 1973-22-4; 1-Bromo-2-Ethylbenzene

该化合物是属于溴化芳烃类别的有机化合物,其特征是溴原子和乙基组,分别附于苯环,具体在1和2个位置上;该化合物一般没有颜色,可粉色黄色,具有典型的芳香味;有机溶剂中可中度溶解,但因其疏水性,在水中溶解性有限;1-Bromo-2-乙基苯用于各种化学合成,并用作生产药品,农用化学品和其他有机化合物的中间体;其活性受溴原子的存在影响,该原子可参与核分裂替代反应;在处理该化合物时,需要谨慎防范,因为吸入或皮肤接触可能会对健康造成危害,因此最好使用适当的个人防护设备.

结构式图片

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号2039-88-5 2-溴苯乙烯 | CAS号100-41-4 乙苯 | CAS号578-54-1 2-乙基苯胺 | CAS号1333-74-0 氢 | CAS号113163-19-2 1-bromo-2-(2-io... | CAS号7364-19-4 1-ethyl-4-tert-... | CAS号6630-33-7 2-溴苯甲醛 | CAS号92-52-4 联苯 | CAS号57190-08-6 2-bromo-4-tert-... | CAS号108059-85-4 2-(2-ethylbenzo... | CAS号34136-59-9 2-乙基苯甲腈 | CAS号1467-06-7 1-(chloromethyl... | CAS号40224-10-0 1-(2-乙基苯基)哌嗪 | CAS号90002-36-1 2-乙基苯硼酸 | CAS号21450-63-5 2-ETHYLPHENYLMA... | CAS号28362-76-7 Benzeneacetalde... | CAS号88-65-3 邻溴苯甲酸 | CAS号1585-07-5 1-溴-4-乙基苯 | CAS号2725-82-8 3-溴乙基苯

合成工艺路线路线简述

    2-乙基苯胺置于氢溴酸,铜,Sodium Nitrite体系中,化学反应生成2-溴乙苯
    参考文献:Notes-Catalytic Synthesis Of Heterocycles. Xi. Dehydrocyclization Of O-Ethylbenzeneselenol To Selenonaphthene
    标题:Notes-Catalytic Synthesis Of Heterocycles. Xi. Dehydrocyclization Of O-Ethylbenzeneselenol To Selenonaphthene
    摘要:
    Doi:10.1021/jo01089A625

    海关参考信息

    专利信息


    专利号:US-7102023-B2
    优先权日:1999-11-24
    标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
    发明人:BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

    专利号:US-6608196-B2
    优先权日:2001-05-03
    标题 :Process for solid supported synthesis of pyruvate-derived compounds
    发明人:WANG BING; JANAGANI SATYANARAYANA; CALLAWAY WYETH B; SESSLER JONATHAN L
    权利人:GALILEO PHARMACEUTICALS INC
    摘要:Provided are processes for synthesizing structurally diverse pyruvate-derived compounds using a parallel approach on a solid phase support. Examples of such a solid phase support include resins which have also been used in solid phase peptide synthesis.

    专利号:US-10865163-B2
    优先权日:2017-12-20
    标题:Carbon dioxide as a directing group for C—H functionalization reactions involving Lewis basic amines, alcohols, thiols, and phosphines for the synthesis of compounds
    发明人:YOUNG MICHAEL C; KAPOOR MOHIT
    权利人:UNIV TOLEDO
    摘要:Methods of synthesizing compounds using CO 2 as a directing group for C—H functionalization, and compounds made thereby, are described.

    专利号:WO-0146142-A1
    优先权日:1999-12-20
    标题:A process for the regioselective synthesis of 2,2-dialkyl-4-substituted piperidines
    发明人:HEATH PERRY CLARK
    权利人:LILLY CO ELI; HEATH PERRY CLARK
    摘要:The present invention provides a process for preparing a compound of formula (I): wherein R?1 and R2¿ each independently represent C¿1?-C4 alkyl; and X represents an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II): wherein Q represents Cl or Br, with a suitable base followed by addition of a suitable Lewis acid and addition of a compound of formula R?-M+¿ wherein M+ is a suitable cation.

    专利号:US-9328061-B2
    优先权日:2012-03-01
    标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
    发明人:HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
    权利人:TRUSTEES BOSTON COLLEGE
    摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
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    合成参考文献


    摘要:Pilgrim, B. S.; Tucker, M. J., Science of Synthesis Knowledge Updates, (2019) 1, 188.
    摘要:Melkonyan, F. S.; Gevorgyan, V., Science of Synthesis: Catalytic Transformations via CH Activation, (2015) 1, 47.
    摘要:Chetcuti, M. J., Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis, (2016) 1, 113.
    摘要:García-Garrido, S. E.; Presa Soto, A.; García-Álvarez, J., Science of Synthesis: Knowledge Updates, (2025) 2.
    摘要:Inagi, S.; Taniguchi, K.; Lam, K., Science of Synthesis: Modern Strategies in Organofluorine Chemistry, (2024) 2.
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